STRINGSTRING
CDHR3 CDHR3 CAV1 CAV1 CLEC5A CLEC5A MRC1 MRC1 CR2 CR2 RAB29 RAB29 CFHR5 CFHR5 XPR1 XPR1 APCS APCS PGLYRP3 PGLYRP3 EPS15 EPS15 EPHA2 EPHA2 TNFRSF14 TNFRSF14 SFTPD SFTPD CDC42 CDC42 NECTIN2 NECTIN2 ENSPTRP00000077428 ENSPTRP00000077428 ENSPTRP00000077287 ENSPTRP00000077287 SRC SRC LOC743586 LOC743586 SLC1A5 SLC1A5 CAV2 CAV2 MYD88 MYD88 HSPD1 HSPD1 CCNK CCNK NCAM1 NCAM1 TSG101 TSG101 ENSPTRP00000062123 ENSPTRP00000062123 TPCN2 TPCN2 ENSPTRP00000062406 ENSPTRP00000062406 LOC101057146 LOC101057146 IGF2R IGF2R INSR INSR IST1 IST1 ROCK2 ROCK2 AGTR1 AGTR1 TFAP4 TFAP4 ZBED1 ZBED1 LAMP1 LAMP1 CHMP4B CHMP4B TNFRSF4 TNFRSF4 ENSPTRP00000064540 ENSPTRP00000064540 SNW1 SNW1 TRIM31 TRIM31 SPRR2B SPRR2B ENSPTRP00000064971 ENSPTRP00000064971 CHMP2A CHMP2A VPS4B VPS4B ENSPTRP00000065655 ENSPTRP00000065655 NUCKS1 NUCKS1 ENSPTRP00000066220 ENSPTRP00000066220 ENSPTRP00000066271 ENSPTRP00000066271 ENSPTRP00000066578 ENSPTRP00000066578 CK820_G0031364-2 CK820_G0031364-2 PI4KA PI4KA LOC748850 LOC748850 LOC740081 LOC740081 VPS37B VPS37B NUP153 NUP153 ITGB3 ITGB3 CK820_G0048024 CK820_G0048024 ENSPTRP00000068785 ENSPTRP00000068785 SLAMF1 SLAMF1 ZC3H12A ZC3H12A LOC740081-2 LOC740081-2 ENSPTRP00000069712 ENSPTRP00000069712 EGFR EGFR ITGB1 ITGB1 ENSPTRP00000070079 ENSPTRP00000070079 VAPA VAPA SLC3A2 SLC3A2 WWP2 WWP2 ENSPTRP00000071392 ENSPTRP00000071392 DEFA5 DEFA5 PIK3C2G PIK3C2G LOC104003887 LOC104003887 ENSPTRP00000072925 ENSPTRP00000072925 SMARCA4 SMARCA4 NECTIN4 NECTIN4 ENSPTRP00000074124 ENSPTRP00000074124 ITGB6 ITGB6 HSPA8 HSPA8 TREM1-2 TREM1-2 ITGB7 ITGB7 HDAC1 HDAC1 ENSPTRP00000075437 ENSPTRP00000075437 LDLR LDLR EEA1 EEA1 ENSPTRP00000089473 ENSPTRP00000089473 LOC473484 LOC473484 BRD4 BRD4 SLC52A2-2 SLC52A2-2 CK820_G0054146 CK820_G0054146 JPT2 JPT2 SERPINB3 SERPINB3 CLDN9 CLDN9 LOC100615317 LOC100615317 EFNB3 EFNB3 ENSPTRP00000087371 ENSPTRP00000087371 CFL1 CFL1 ENSPTRP00000087328 ENSPTRP00000087328 GYPB GYPB AXL AXL ENSPTRP00000086838 ENSPTRP00000086838 F11R F11R ENSPTRP00000085944 ENSPTRP00000085944 ENSPTRP00000085514 ENSPTRP00000085514 SLC52A2 SLC52A2 CLDN9-2 CLDN9-2 ENSPTRP00000093266 ENSPTRP00000093266 TUSC2 TUSC2 ENSPTRP00000091771 ENSPTRP00000091771 LOC741829 LOC741829 INHBB INHBB ENSPTRP00000090837 ENSPTRP00000090837 VPS4A VPS4A ENSPTRP00000090651 ENSPTRP00000090651 IFIT1 IFIT1 ENSPTRP00000089678 ENSPTRP00000089678 ALYREF ALYREF CK820_G0045089 CK820_G0045089 ICAM1 ICAM1 CLEC5A-2 CLEC5A-2 STOM STOM CCL5 CCL5 ITGA2 ITGA2 LOC472599 LOC472599 JAK2 JAK2 LOC467037 LOC467037 CARD9 CARD9 SPRR2A SPRR2A ENSPTRP00000093626 ENSPTRP00000093626 ENSPTRP00000093588 ENSPTRP00000093588 ROMO1-2 ROMO1-2 DDB1 DDB1 ENSPTRP00000081714 ENSPTRP00000081714 CD46 CD46 ENSPTRP00000081048 ENSPTRP00000081048 CSF1R CSF1R LOC100610057 LOC100610057 TREM1 TREM1 ENSPTRP00000080552 ENSPTRP00000080552 NPC1 NPC1 FBXL2 FBXL2 ENSPTRP00000080343 ENSPTRP00000080343 NECTIN1 NECTIN1 MOG MOG ENSPTRP00000080002 ENSPTRP00000080002 LEF1 LEF1 ATG7 ATG7 SCARB1 SCARB1 ENSPTRP00000079495 ENSPTRP00000079495 LOC471113 LOC471113 VAMP8 VAMP8 LOC745935 LOC745935 NRP1 NRP1 NLRP6 NLRP6 SMPD1 SMPD1 TMEM41B TMEM41B F2 F2 PSMC3 PSMC3 GRK2 GRK2 UVRAG UVRAG CBL CBL POU2F3 POU2F3 GAPDH GAPDH CCNT1 CCNT1 SP1 SP1 ITGA5 ITGA5 TPCN1 TPCN1 HTR2A HTR2A KPNA3 KPNA3 EFNB2 EFNB2 CTSG CTSG SLC10A1 SLC10A1 IFI27 IFI27 SIVA1 SIVA1 EIF2AK4 EIF2AK4 VPS18 VPS18 TYRO3 TYRO3 PPIB PPIB ANPEP ANPEP THOC6 THOC6 SCNN1B SCNN1B CHMP1A CHMP1A SLC52A1 SLC52A1 CCL8 CCL8 PHB PHB TRIM25 TRIM25 C17H17orf64 C17H17orf64 ST6GALNAC1 ST6GALNAC1 THOC1 THOC1 CTDP1 CTDP1 ELANE ELANE BSG BSG AZU1 AZU1 CLEC4G CLEC4G PGLYRP2 PGLYRP2 HPN HPN PVR PVR PGLYRP1 PGLYRP1 CHMP3 CHMP3 PIKFYVE PIKFYVE AVP AVP SIGLEC1 SIGLEC1 BCL2L1 BCL2L1 CXADR CXADR RRP1B RRP1B EP300 EP300 ARL8B ARL8B RAB5A RAB5A RPSA RPSA ZNF502 ZNF502 LTF LTF CAMP CAMP DAG1 DAG1 THOC7 THOC7 CHMP2B CHMP2B GPR15 GPR15 CD80 CD80 CD86 CD86 PTX3 PTX3 ZNF639 ZNF639 HRG HRG CLDN1 CLDN1 LRRC15 LRRC15 PF4 PF4 SCARB2 SCARB2 ENSPTRP00000028285 ENSPTRP00000028285 GYPA GYPA PPID PPID SAP30 SAP30 CHD1 CHD1 YTHDC2 YTHDC2 HAVCR1 HAVCR1 TAF11 TAF11 HSP90AB1 HSP90AB1 DYNLT1 DYNLT1 TCP1 TCP1 PLG PLG PRKN PRKN NAPEPLD NAPEPLD DEFB103A DEFB103A CTSB CTSB CHMP7 CHMP7 SLC20A2 SLC20A2 CHMP4C CHMP4C WWP1 WWP1 LRRC19 LRRC19 CHMP5 CHMP5 CTSL CTSL CDK9 CDK9 RAB9A RAB9A ACE2 ACE2 THOC2 THOC2 FMR1 FMR1 INPP5K INPP5K REST REST THOC5 THOC5 SMARCB1 SMARCB1 DPP4 DPP4 FN1 FN1 ITCH ITCH AVPR1B AVPR1B CFHR1 CFHR1 ROMO1 ROMO1 PC PC THOC3 THOC3 TFRC TFRC HYAL2 HYAL2 ITGAV ITGAV IDE IDE CDK1 CDK1 PLSCR1 PLSCR1 ITGB5 ITGB5 HMGA2 HMGA2 REG3G REG3G TBC1D20 TBC1D20 SAP30BP SAP30BP RNASEK RNASEK APOE APOE GYPE1 GYPE1 DDX39B DDX39B CLEC4M CLEC4M CD55 CD55 TRIM62 TRIM62 CCL3 CCL3 CX3CR1 CX3CR1 VAPB VAPB SELPLG SELPLG CD209L2 CD209L2 LOC745166 LOC745166 ENSPTRP00000060289 ENSPTRP00000060289 DCD DCD RPSA-2 RPSA-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDHR3Cadherin related family member 3. (885 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CLEC5AC-type lectin domain containing 5A. (188 aa)
MRC1Mannose receptor C-type 1. (1456 aa)
CR2Complement C3d receptor 2. (1033 aa)
RAB29RAB7, member RAS oncogene family-like 1. (203 aa)
CFHR5CFHR5 isoform 1. (569 aa)
XPR1Xenotropic and polytropic retrovirus receptor 1. (696 aa)
APCSPentaxin. (223 aa)
PGLYRP3PGLYRP3 isoform 1. (341 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (896 aa)
EPHA2EPH receptor A2. (976 aa)
TNFRSF14Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator). (283 aa)
SFTPDSurfactant protein D. (375 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
NECTIN2Poliovirus receptor-related 2 (Herpesvirus entry mediator B). (542 aa)
ENSPTRP00000077428annotation not available (202 aa)
ENSPTRP00000077287annotation not available (417 aa)
SRCTyrosine-protein kinase. (542 aa)
LOC743586T-complex protein 1 subunit alpha pseudogene. (338 aa)
SLC1A5Amino acid transporter. (541 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
HSPD1Heat shock 60kDa protein 1 (Chaperonin); Belongs to the chaperonin (HSP60) family. (598 aa)
CCNKCCNK isoform 2; Belongs to the cyclin family. (572 aa)
NCAM1Neural cell adhesion molecule 1. (884 aa)
TSG101Tumor susceptibility 101. (405 aa)
ENSPTRP00000062123annotation not available (256 aa)
TPCN2Two pore segment channel 2. (752 aa)
ENSPTRP00000062406annotation not available (534 aa)
LOC101057146Putative charged multivesicular body protein 4B-like protein CHMP4BP1. (194 aa)
IGF2RIGF2R isoform 2. (2491 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
IST1IST1 factor associated with ESCRT-III. (376 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. (394 aa)
TFAP4Transcription factor AP-4 (Activating enhancer binding protein 4). (338 aa)
ZBED1Zinc finger, BED-type containing 1. (694 aa)
LAMP1Lysosome-associated membrane glycoprotein 1. (465 aa)
CHMP4BCharged multivesicular body protein 4B. (271 aa)
TNFRSF4TNFRSF4 isoform 2. (272 aa)
ENSPTRP00000064540annotation not available (358 aa)
SNW1SNW domain containing 1. (571 aa)
TRIM31TRIM31 isoform 1. (474 aa)
SPRR2BSmall proline-rich protein 2A. (72 aa)
ENSPTRP00000064971annotation not available (587 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (446 aa)
ENSPTRP00000065655annotation not available (349 aa)
NUCKS1Nuclear casein kinase and cyclin-dependent kinase substrate 1. (243 aa)
ENSPTRP00000066220annotation not available (211 aa)
ENSPTRP00000066271annotation not available (782 aa)
ENSPTRP00000066578annotation not available (310 aa)
CK820_G0031364-2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
PI4KAPI4KA isoform 3; Belongs to the PI3/PI4-kinase family. (1915 aa)
LOC748850HDAC2 isoform 9. (445 aa)
LOC740081Small subunit ribosomal protein SAe. (286 aa)
VPS37BVacuolar protein sorting 37 homolog B. (285 aa)
NUP153NUP153 isoform 1. (1506 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
CK820_G0048024CHMP6 isoform 1. (157 aa)
ENSPTRP00000068785annotation not available (127 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (357 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
LOC740081-2Small subunit ribosomal protein SAe. (295 aa)
ENSPTRP00000069712annotation not available (201 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ENSPTRP00000070079annotation not available (198 aa)
VAPAVAPA isoform 3. (294 aa)
SLC3A2Solute carrier family 3 member 2. (631 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
ENSPTRP00000071392annotation not available (233 aa)
DEFA5Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family. (94 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1486 aa)
LOC104003887Charged multivesicular body protein 5 pseudogene. (198 aa)
ENSPTRP00000072925annotation not available (372 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
NECTIN4Nectin cell adhesion molecule 4. (510 aa)
ENSPTRP00000074124annotation not available (400 aa)
ITGB6ITGB6 isoform 3. (701 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
TREM1-2TREM1 isoform 1. (270 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (802 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ENSPTRP00000075437annotation not available (353 aa)
LDLRLDLR isoform 7. (917 aa)
EEA1Early endosome antigen 1. (1411 aa)
ENSPTRP00000089473annotation not available (177 aa)
LOC473484Cathepsin L1. (276 aa)
BRD4Bromodomain containing 4. (1362 aa)
SLC52A2-2Solute carrier family 52 member 2. (453 aa)
CK820_G0054146PI4KA isoform 16; Belongs to the PI3/PI4-kinase family. (136 aa)
JPT2Jupiter microtubule associated homolog 2. (218 aa)
SERPINB3SERPINB3 isoform 1; Belongs to the serpin family. (390 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
LOC100615317IST1 isoform 5. (331 aa)
EFNB3EFNB3 isoform 1; Belongs to the ephrin family. (340 aa)
ENSPTRP00000087371annotation not available (54 aa)
CFL1CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. (204 aa)
ENSPTRP00000087328annotation not available (242 aa)
GYPBGlycophorin-B; This protein is a minor sialoglycoprotein in erythrocyte membranes. (124 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
ENSPTRP00000086838annotation not available (279 aa)
F11RF11R isoform 1. (322 aa)
ENSPTRP00000085944annotation not available (167 aa)
ENSPTRP00000085514annotation not available (279 aa)
SLC52A2Solute carrier family 52 member 2. (453 aa)
CLDN9-2Claudin 9. (217 aa)
ENSPTRP00000093266annotation not available (417 aa)
TUSC2Tumor suppressor 2, mitochondrial calcium regulator. (110 aa)
ENSPTRP00000091771annotation not available (149 aa)
LOC74182940S ribosomal protein SA pseudogene. (289 aa)
INHBBInhibin subunit beta B. (407 aa)
ENSPTRP00000090837annotation not available (341 aa)
VPS4AVacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (505 aa)
ENSPTRP00000090651annotation not available (267 aa)
IFIT1Interferon-induced protein with tetratricopeptide repeats 1. (478 aa)
ENSPTRP00000089678annotation not available (488 aa)
ALYREFAly/REF export factor. (285 aa)
CK820_G0045089RANBP3 isoform 23. (97 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
CLEC5A-2C-type lectin domain containing 5A. (188 aa)
STOMSTOM isoform 3. (288 aa)
CCL5C-C motif chemokine. (91 aa)
ITGA2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
LOC472599Heat shock cognate 71 kDa protein pseudogene. (400 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
LOC46703760 kDa heat shock protein, mitochondrial pseudogene. (481 aa)
CARD9Caspase recruitment domain family, member 9. (536 aa)
SPRR2ASmall proline-rich protein 2A. (72 aa)
ENSPTRP00000093626annotation not available (450 aa)
ENSPTRP00000093588annotation not available (361 aa)
ROMO1-2Reactive oxygen species modulator 1. (79 aa)
DDB1Damage-specific DNA binding protein 1, 127kDa. (1147 aa)
ENSPTRP00000081714annotation not available (310 aa)
CD46CD46 isoform 5. (432 aa)
ENSPTRP00000081048Small subunit ribosomal protein SAe. (176 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
LOC10061005740S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (295 aa)
TREM1Triggering receptor expressed on myeloid cells 1. (270 aa)
ENSPTRP00000080552annotation not available (187 aa)
NPC1Niemann-Pick disease, type C1. (1280 aa)
FBXL2F-box and leucine rich repeat protein 2. (472 aa)
ENSPTRP00000080343annotation not available (123 aa)
NECTIN1NECTIN1 isoform 1. (517 aa)
MOGMyelin oligodendrocyte glycoprotein. (295 aa)
ENSPTRP00000080002annotation not available (967 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
SCARB1SCARB1 isoform 8; Belongs to the CD36 family. (552 aa)
ENSPTRP00000079495annotation not available (194 aa)
LOC471113NEDD4-like E3 ubiquitin-protein ligase WWP1 pseudogene. (783 aa)
VAMP8Vesicle associated membrane protein 8. (115 aa)
LOC745935C-C motif chemokine. (87 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
NLRP6NLR family pyrin domain containing 6. (892 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (504 aa)
TMEM41BTransmembrane protein 41B. (291 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
PSMC3Proteasome (Prosome, macropain) 26S subunit, ATPase, 3; Belongs to the AAA ATPase family. (446 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
UVRAGUV radiation resistance associated protein. (699 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
POU2F3POU domain protein. (436 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
CCNT1Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of SIV infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing [...] (725 aa)
SP1Sp1 transcription factor. (786 aa)
ITGA5ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa)
TPCN1TPCN1 isoform 2. (888 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
KPNA3Importin subunit alpha; Functions in nuclear protein import. (521 aa)
EFNB2EFNB2 isoform 1; Belongs to the ephrin family. (333 aa)
CTSGCTSG isoform 2; Belongs to the peptidase S1 family. (255 aa)
SLC10A1Solute carrier family 10 member 1. (349 aa)
IFI27Interferon, alpha-inducible protein 27. (122 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
VPS18VPS18 core subunit of CORVET and HOPS complexes. (973 aa)
TYRO3TYRO3 protein tyrosine kinase. (890 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
ANPEPAminopeptidase. (967 aa)
THOC6THO complex 6 homolog. (341 aa)
SCNN1BAmiloride-sensitive sodium channel subunit beta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception; Belongs to the amiloride-sensit [...] (685 aa)
CHMP1ACHMP1A isoform 6. (112 aa)
SLC52A1SLC52A1 isoform 1. (448 aa)
CCL8C-C motif chemokine. (109 aa)
PHBProhibitin. (272 aa)
TRIM25Tripartite motif containing 25. (630 aa)
C17H17orf64Chromosome 17 C17orf64 homolog. (236 aa)
ST6GALNAC1ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (600 aa)
THOC1THOC1 isoform 2. (664 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (961 aa)
ELANEElastase, neutrophil expressed. (267 aa)
BSGBSG isoform 8. (383 aa)
AZU1AZU1 isoform 1. (253 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
PGLYRP2Peptidoglycan recognition protein 2. (634 aa)
HPNHPN isoform 1; Belongs to the peptidase S1 family. (417 aa)
PVRPVR cell adhesion molecule. (417 aa)
PGLYRP1Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (196 aa)
CHMP3Charged multivesicular body protein 3 isoform X1. (222 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
SIGLEC1Sialic acid binding Ig like lectin 1. (1709 aa)
BCL2L1BCL2L1 isoform 6. (233 aa)
CXADRCXADR Ig-like cell adhesion molecule. (365 aa)
RRP1BRibosomal RNA processing 1 homolog B. (758 aa)
EP300E1A binding protein p300. (2175 aa)
ARL8BADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family. (186 aa)
RAB5ARAB5A, member RAS oncogene family. (216 aa)
RPSARibosomal protein SA. (301 aa)
ZNF502Zinc finger protein 502. (544 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
CAMPCathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. (173 aa)
DAG1Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
THOC7THO complex 7 homolog. (204 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
GPR15G-protein coupled receptor 15; Probable chemokine receptor. SIV-1 coreceptor; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CD80CD80 isoform 1. (288 aa)
CD86CD86 isoform 3. (329 aa)
PTX3Pentraxin 3, long. (381 aa)
ZNF639Zinc finger protein 639. (485 aa)
HRGHistidine rich glycoprotein. (525 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
LRRC15Leucine rich repeat containing 15. (587 aa)
PF4C-X-C motif chemokine. (101 aa)
SCARB2Scavenger receptor class B, member 2; Belongs to the CD36 family. (478 aa)
ENSPTRP00000028285annotation not available (77 aa)
GYPAGlycophorin-A; Glycophorin A is the major intrinsic membrane protein of the erythrocyte. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane (By similarity). (149 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
SAP30Sin3A-associated protein, 30kDa. (220 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1710 aa)
YTHDC2YTH domain containing 2. (1430 aa)
HAVCR1Hepatitis A virus cellular receptor 1. (402 aa)
TAF11TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa. (211 aa)
HSP90AB1HSP90AB1 isoform 1. (688 aa)
DYNLT1Dynein, light chain, Tctex-type 1. (113 aa)
TCP1T-complex protein 1 subunit alpha. (556 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (393 aa)
DEFB103ABeta-defensin 103A; Exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria; Belongs to the beta-defensin family. (67 aa)
CTSBCTSB isoform 10; Belongs to the peptidase C1 family. (339 aa)
CHMP7Charged multivesicular body protein 7. (453 aa)
SLC20A2Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. (652 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
WWP1E3 ubiquitin-protein ligase. (922 aa)
LRRC19Leucine rich repeat containing 19. (370 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
CTSLCTSL isoform 2; Belongs to the peptidase C1 family. (333 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
RAB9ARAB9A isoform 1. (201 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
THOC2THOC2 isoform 2. (1595 aa)
FMR1Fragile X mental retardation 1. (632 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (448 aa)
RESTRE1 silencing transcription factor. (1097 aa)
THOC5THOC5 isoform 1. (683 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (394 aa)
DPP4Dipeptidyl-peptidase 4; Belongs to the peptidase S9B family. (766 aa)
FN1FN1 isoform 1. (2477 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
CFHR1T0196413 isoform 1. (282 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1179 aa)
THOC3THOC3 isoform 4. (351 aa)
TFRCTransferrin receptor (P90, CD71). (760 aa)
HYAL2Hyaluronidase. (473 aa)
ITGAVIntegrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
IDEInsulin-degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
PLSCR1Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (318 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
REG3GRegenerating islet-derived protein 3-gamma. (174 aa)
TBC1D20TBC1 domain family, member 20. (403 aa)
SAP30BPSAP30 binding protein. (308 aa)
RNASEKRibonuclease, RNase K. (137 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
GYPE1GYPA isoform 5. (121 aa)
DDX39BSpliceosome RNA helicase DDX39B; Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pat [...] (428 aa)
CLEC4MC-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). (445 aa)
CD55CD55 isoform 7. (551 aa)
TRIM62Tripartite motif containing 62. (475 aa)
CCL3C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (92 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
VAPBVAMP (Vesicle-associated membrane protein)-associated protein B and C. (243 aa)
SELPLGSELPLG isoform 2. (428 aa)
CD209L2CD209 isoform 3. (256 aa)
LOC745166HSPA1A isoform 1; Belongs to the heat shock protein 70 family. (643 aa)
ENSPTRP00000060289annotation not available (844 aa)
DCDDCD isoform 2. (120 aa)
RPSA-2Small subunit ribosomal protein SAe. (206 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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