(48 nodes) T cell selection network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TBX21	T-box transcription factor 21. (535 aa)
	ZFPM1	ZFPM1 isoform 1. (974 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (125 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	CD3G	CD3G isoform 1. (182 aa)
	CD3D	CD3D isoform 1. (171 aa)
	CD3E	CD3E isoform 2. (207 aa)
	ITPKB	Kinase; Belongs to the inositol phosphokinase (IPK) family. (946 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1306 aa)
	LY9	LY9 isoform 4. (655 aa)
	IL6R	Interleukin 6 receptor. (442 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	TOX	Thymocyte selection-associated high mobility group box. (526 aa)
	CTSL	CTSL isoform 2; Belongs to the peptidase C1 family. (333 aa)
	FOXP3	FOXP3 isoform 4. (456 aa)
	CD74	CD74 isoform 5. (296 aa)
	SLAMF6	SLAM family member 6. (332 aa)
	BCL11B	BAF chromatin remodeling complex subunit BCL11B. (894 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	SPN	SPN isoform 3. (400 aa)
	CD4	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
	GATA3	GATA binding protein 3. (444 aa)
	SPN-2	SPN isoform 1. (418 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	IL6	Interleukin 6 (Interferon, beta 2). (234 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	JAG2	Jagged canonical Notch ligand 2. (1130 aa)
	PGBD4	PiggyBac transposable element derived 4. (585 aa)
	BRAF	BRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
	IL6-2	Interleukin 6. (234 aa)
	CARD11	Caspase recruitment domain family, member 11. (1154 aa)
	BRAF-2	BRAF isoform 2. (766 aa)
	LOC473484	Cathepsin L1. (276 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	ENSPTRP00000090382	annotation not available (493 aa)
	STAT3	Signal transducer and activator of transcription. (790 aa)
	THEMIS	Thymocyte selection associated. (680 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	SRF	Serum response factor (C-fos serum response element-binding transcription factor). (508 aa)
	IRF4	Interferon regulatory factor 4. (451 aa)
	DOCK2	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
	RHOA	Ras homolog family member A. (193 aa)
	AIRE	Autoimmune regulator. (545 aa)
	CD28	CD28 isoform 3. (220 aa)
	ZAP70	Tyrosine-protein kinase. (619 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIRE	CD4	ENSPTRP00000024049	ENSPTRP00000054833	Autoimmune regulator.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.484
AIRE	FOXP3	ENSPTRP00000024049	ENSPTRP00000037587	Autoimmune regulator.	FOXP3 isoform 4.	0.487
ATG5	BCL2	ENSPTRP00000031526	ENSPTRP00000090293	Autophagy protein 5; Involved in autophagic vesicle formation.	BCL2 apoptosis regulator.	0.703
ATG5	CD4	ENSPTRP00000031526	ENSPTRP00000054833	Autophagy protein 5; Involved in autophagic vesicle formation.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.491
ATG5	MTOR	ENSPTRP00000031526	ENSPTRP00000000280	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.597
ATG5	STAT3	ENSPTRP00000031526	ENSPTRP00000091410	Autophagy protein 5; Involved in autophagic vesicle formation.	Signal transducer and activator of transcription.	0.404
BATF	BCL11B	ENSPTRP00000011135	ENSPTRP00000052505	Basic leucine zipper ATF-like transcription factor.	BAF chromatin remodeling complex subunit BCL11B.	0.420
BATF	CD28	ENSPTRP00000011135	ENSPTRP00000021943	Basic leucine zipper ATF-like transcription factor.	CD28 isoform 3.	0.427
BATF	CD4	ENSPTRP00000011135	ENSPTRP00000054833	Basic leucine zipper ATF-like transcription factor.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.575
BATF	FOXP3	ENSPTRP00000011135	ENSPTRP00000037587	Basic leucine zipper ATF-like transcription factor.	FOXP3 isoform 4.	0.506
BATF	GATA3	ENSPTRP00000011135	ENSPTRP00000064658	Basic leucine zipper ATF-like transcription factor.	GATA binding protein 3.	0.540
BATF	IRF4	ENSPTRP00000011135	ENSPTRP00000030162	Basic leucine zipper ATF-like transcription factor.	Interferon regulatory factor 4.	0.907
BATF	STAT3	ENSPTRP00000011135	ENSPTRP00000091410	Basic leucine zipper ATF-like transcription factor.	Signal transducer and activator of transcription.	0.686
BATF	STAT6	ENSPTRP00000011135	ENSPTRP00000008702	Basic leucine zipper ATF-like transcription factor.	Signal transducer and activator of transcription.	0.506
BATF	TBX21	ENSPTRP00000011135	ENSPTRP00000015869	Basic leucine zipper ATF-like transcription factor.	T-box transcription factor 21.	0.600
BCL11B	BATF	ENSPTRP00000052505	ENSPTRP00000011135	BAF chromatin remodeling complex subunit BCL11B.	Basic leucine zipper ATF-like transcription factor.	0.420
BCL11B	GATA3	ENSPTRP00000052505	ENSPTRP00000064658	BAF chromatin remodeling complex subunit BCL11B.	GATA binding protein 3.	0.513
BCL2	ATG5	ENSPTRP00000090293	ENSPTRP00000031526	BCL2 apoptosis regulator.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.703
BCL2	BRAF	ENSPTRP00000090293	ENSPTRP00000079485	BCL2 apoptosis regulator.	BRAF isoform 1; Belongs to the protein kinase superfamily.	0.558
BCL2	BRAF-2	ENSPTRP00000090293	ENSPTRP00000089230	BCL2 apoptosis regulator.	BRAF isoform 2.	0.558