19 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GATA3	GATA binding protein 3. (444 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	ITPKB	Kinase; Belongs to the inositol phosphokinase (IPK) family. (946 aa)
	CD3E	CD3E isoform 2. (207 aa)
	CD3D	CD3D isoform 1. (171 aa)
	CD3G	CD3G isoform 1. (182 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1306 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
	ZAP70	Tyrosine-protein kinase. (619 aa)
	CD28	CD28 isoform 3. (220 aa)
	AIRE	Autoimmune regulator. (545 aa)
	JAG2	Jagged canonical Notch ligand 2. (1130 aa)
	CARD11	Caspase recruitment domain family, member 11. (1154 aa)
	DOCK2	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
	SRF	Serum response factor (C-fos serum response element-binding transcription factor). (508 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	CD74	CD74 isoform 5. (296 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD11	CD28	ENSPTRP00000085421	ENSPTRP00000021943	Caspase recruitment domain family, member 11.	CD28 isoform 3.	0.744
CARD11	ZAP70	ENSPTRP00000085421	ENSPTRP00000021008	Caspase recruitment domain family, member 11.	Tyrosine-protein kinase.	0.617
CCR7	CD28	ENSPTRP00000053043	ENSPTRP00000021943	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD28 isoform 3.	0.758
CCR7	CD3D	ENSPTRP00000053043	ENSPTRP00000007442	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD3D isoform 1.	0.559
CCR7	CD3E	ENSPTRP00000053043	ENSPTRP00000007441	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD3E isoform 2.	0.592
CCR7	CD3G	ENSPTRP00000053043	ENSPTRP00000007443	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD3G isoform 1.	0.552
CCR7	GATA3	ENSPTRP00000053043	ENSPTRP00000064658	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	GATA binding protein 3.	0.481
CCR7	PTPRC	ENSPTRP00000053043	ENSPTRP00000003034	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Protein tyrosine phosphatase receptor type C.	0.694
CCR7	ZAP70	ENSPTRP00000053043	ENSPTRP00000021008	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Tyrosine-protein kinase.	0.503
CD28	CARD11	ENSPTRP00000021943	ENSPTRP00000085421	CD28 isoform 3.	Caspase recruitment domain family, member 11.	0.744
CD28	CCR7	ENSPTRP00000021943	ENSPTRP00000053043	CD28 isoform 3.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.758
CD28	CD3D	ENSPTRP00000021943	ENSPTRP00000007442	CD28 isoform 3.	CD3D isoform 1.	0.463
CD28	CD3E	ENSPTRP00000021943	ENSPTRP00000007441	CD28 isoform 3.	CD3E isoform 2.	0.629
CD28	CD3G	ENSPTRP00000021943	ENSPTRP00000007443	CD28 isoform 3.	CD3G isoform 1.	0.512
CD28	DOCK2	ENSPTRP00000021943	ENSPTRP00000029919	CD28 isoform 3.	Dedicator of cytokinesis 2; Belongs to the DOCK family.	0.483
CD28	GATA3	ENSPTRP00000021943	ENSPTRP00000064658	CD28 isoform 3.	GATA binding protein 3.	0.481
CD28	PTPRC	ENSPTRP00000021943	ENSPTRP00000003034	CD28 isoform 3.	Protein tyrosine phosphatase receptor type C.	0.646
CD28	ZAP70	ENSPTRP00000021943	ENSPTRP00000021008	CD28 isoform 3.	Tyrosine-protein kinase.	0.743
CD3D	CCR7	ENSPTRP00000007442	ENSPTRP00000053043	CD3D isoform 1.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.559
CD3D	CD28	ENSPTRP00000007442	ENSPTRP00000021943	CD3D isoform 1.	CD28 isoform 3.	0.463