(27 nodes) Isotype switching network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EXO1	EXO1 isoform 1. (846 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	UNG	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (125 aa)
	EXOSC6	Exosome complex component MTR3. (272 aa)
	ATAD5	ATPase family AAA domain containing 5. (1844 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
	MLH1	MutL homolog 1, colon cancer, nonpolyposis type 2. (756 aa)
	EXOSC3	Exosome complex exonuclease RRP40. (275 aa)
	FOXP3	FOXP3 isoform 4. (456 aa)
	LIG4	DNA ligase. (911 aa)
	KIAA1841	KIAA1841 isoform 3. (718 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa)
	HSPD1	Heat shock 60kDa protein 1 (Chaperonin); Belongs to the chaperonin (HSP60) family. (598 aa)
	DEF6	DEF6 guanine nucleotide exchange factor. (631 aa)
	ENSPTRP00000064971	annotation not available (587 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (865 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	SWAP70	SWAP70 isoform 1. (585 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
	LOC467037	60 kDa heat shock protein, mitochondrial pseudogene. (481 aa)
	XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4. (334 aa)
	RNF168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (505 aa)
	ENSPTRP00000086877	annotation not available (313 aa)
	AICDA	Activation induced cytidine deaminase. (199 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AICDA	BCL6	ENSPTRP00000091417	ENSPTRP00000068244	Activation induced cytidine deaminase.	BCL6 transcription repressor.	0.773
AICDA	CD40LG	ENSPTRP00000091417	ENSPTRP00000077615	Activation induced cytidine deaminase.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.662
AICDA	ENSPTRP00000086877	ENSPTRP00000091417	ENSPTRP00000086877	Activation induced cytidine deaminase.	annotation not available	0.632
AICDA	LIG4	ENSPTRP00000091417	ENSPTRP00000042757	Activation induced cytidine deaminase.	DNA ligase.	0.469
AICDA	MSH6	ENSPTRP00000091417	ENSPTRP00000020434	Activation induced cytidine deaminase.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.500
AICDA	UNG	ENSPTRP00000091417	ENSPTRP00000009190	Activation induced cytidine deaminase.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.	0.743
ATAD5	EXO1	ENSPTRP00000015300	ENSPTRP00000003664	ATPase family AAA domain containing 5.	EXO1 isoform 1.	0.921
ATAD5	LIG4	ENSPTRP00000015300	ENSPTRP00000042757	ATPase family AAA domain containing 5.	DNA ligase.	0.630
ATAD5	MSH6	ENSPTRP00000015300	ENSPTRP00000020434	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.467
ATAD5	NBN	ENSPTRP00000015300	ENSPTRP00000053119	ATPase family AAA domain containing 5.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.461
BATF	BCL6	ENSPTRP00000011135	ENSPTRP00000068244	Basic leucine zipper ATF-like transcription factor.	BCL6 transcription repressor.	0.710
BATF	FOXP3	ENSPTRP00000011135	ENSPTRP00000037587	Basic leucine zipper ATF-like transcription factor.	FOXP3 isoform 4.	0.506
BATF	STAT6	ENSPTRP00000011135	ENSPTRP00000008702	Basic leucine zipper ATF-like transcription factor.	Signal transducer and activator of transcription.	0.506
BCL6	AICDA	ENSPTRP00000068244	ENSPTRP00000091417	BCL6 transcription repressor.	Activation induced cytidine deaminase.	0.773
BCL6	BATF	ENSPTRP00000068244	ENSPTRP00000011135	BCL6 transcription repressor.	Basic leucine zipper ATF-like transcription factor.	0.710
BCL6	CD40LG	ENSPTRP00000068244	ENSPTRP00000077615	BCL6 transcription repressor.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.605
BCL6	FOXP3	ENSPTRP00000068244	ENSPTRP00000037587	BCL6 transcription repressor.	FOXP3 isoform 4.	0.617
BCL6	STAT6	ENSPTRP00000068244	ENSPTRP00000008702	BCL6 transcription repressor.	Signal transducer and activator of transcription.	0.677
CD40LG	AICDA	ENSPTRP00000077615	ENSPTRP00000091417	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Activation induced cytidine deaminase.	0.662
CD40LG	BCL6	ENSPTRP00000077615	ENSPTRP00000068244	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	BCL6 transcription repressor.	0.605