node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDX17 | DDX5 | ENSPTRP00000062822 | ENSPTRP00000016210 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] | 0.951 |
DDX17 | MBNL1 | ENSPTRP00000062822 | ENSPTRP00000084465 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | Muscleblind like splicing regulator 1. | 0.541 |
DDX17 | MYOD1 | ENSPTRP00000062822 | ENSPTRP00000005943 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. | 0.689 |
DDX5 | DDX17 | ENSPTRP00000016210 | ENSPTRP00000062822 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | 0.951 |
DDX5 | MBNL1 | ENSPTRP00000016210 | ENSPTRP00000084465 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] | Muscleblind like splicing regulator 1. | 0.513 |
DDX5 | MYOCD | ENSPTRP00000016210 | ENSPTRP00000014974 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] | MYOCD isoform 2. | 0.478 |
DDX5 | MYOD1 | ENSPTRP00000016210 | ENSPTRP00000005943 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. | 0.655 |
EPAS1 | IGF1 | ENSPTRP00000020413 | ENSPTRP00000067917 | Endothelial PAS domain protein 1. | Insulin-like growth factor 1 (Somatomedin C). | 0.465 |
EPAS1 | NOTCH1 | ENSPTRP00000020413 | ENSPTRP00000036924 | Endothelial PAS domain protein 1. | NOTCH1 isoform 1. | 0.640 |
FGF6 | IGF1 | ENSPTRP00000085321 | ENSPTRP00000067917 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Insulin-like growth factor 1 (Somatomedin C). | 0.655 |
FGF6 | SDC1 | ENSPTRP00000085321 | ENSPTRP00000065998 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. | 0.677 |
FGF6 | SHH | ENSPTRP00000085321 | ENSPTRP00000075730 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.682 |
IGF1 | EPAS1 | ENSPTRP00000067917 | ENSPTRP00000020413 | Insulin-like growth factor 1 (Somatomedin C). | Endothelial PAS domain protein 1. | 0.465 |
IGF1 | FGF6 | ENSPTRP00000067917 | ENSPTRP00000085321 | Insulin-like growth factor 1 (Somatomedin C). | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.655 |
IGF1 | MYOD1 | ENSPTRP00000067917 | ENSPTRP00000005943 | Insulin-like growth factor 1 (Somatomedin C). | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. | 0.487 |
IGF1 | PLG | ENSPTRP00000067917 | ENSPTRP00000032051 | Insulin-like growth factor 1 (Somatomedin C). | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.452 |
IGF1 | SDC1 | ENSPTRP00000067917 | ENSPTRP00000065998 | Insulin-like growth factor 1 (Somatomedin C). | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. | 0.465 |
IGF1 | SHH | ENSPTRP00000067917 | ENSPTRP00000075730 | Insulin-like growth factor 1 (Somatomedin C). | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.461 |
ISL1 | SHH | ENSPTRP00000028882 | ENSPTRP00000075730 | ISL LIM homeobox 1. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.534 |
ISL1 | TBX2 | ENSPTRP00000028882 | ENSPTRP00000016104 | ISL LIM homeobox 1. | T-box transcription factor 2. | 0.565 |