STRINGSTRING
IFRD1 IFRD1 MYOD1 MYOD1 WNT10B WNT10B RB1 RB1 SOX15 SOX15 MYOCD MYOCD TBX2 TBX2 DDX5 DDX5 EPAS1 EPAS1 MAML1 MAML1 DDX17 DDX17 SDC1 SDC1 HINFP HINFP IGF1 IGF1 ITGB1 ITGB1 SHH SHH RBPJ RBPJ WNT3A WNT3A MAPK12 MAPK12 PLEKHM3 PLEKHM3 TCF7L2 TCF7L2 MBNL1 MBNL1 FGF6 FGF6 NRG1 NRG1 JAG1 JAG1 LGALS1 LGALS1 ISL1 ISL1 MEGF10 MEGF10 PITX1 PITX1 SRF SRF PLG PLG TBXT TBXT PLEC PLEC NOTCH1 NOTCH1 REST REST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFRD1Interferon-related developmental regulator 1. (452 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
RB1RB transcriptional corepressor 1. (928 aa)
SOX15SOX15 isoform 1. (233 aa)
MYOCDMYOCD isoform 2. (986 aa)
TBX2T-box transcription factor 2. (712 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
MAML1MAML1 isoform 1. (1016 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (735 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
HINFPHistone H4 transcription factor. (518 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
PLEKHM3Pleckstrin homology domain containing, family M, member 3. (761 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
MBNL1Muscleblind like splicing regulator 1. (400 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NRG1NRG1 isoform 3. (713 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
LGALS1Galectin. (135 aa)
ISL1ISL LIM homeobox 1. (349 aa)
MEGF10MEGF10 isoform 2. (1140 aa)
PITX1Homeobox protein. (314 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
TBXTT-box transcription factor T. (435 aa)
PLECPLEC isoform 2. (4684 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
RESTRE1 silencing transcription factor. (1097 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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