35 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IFRD1	Interferon-related developmental regulator 1. (452 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	RB1	RB transcriptional corepressor 1. (928 aa)
	SOX15	SOX15 isoform 1. (233 aa)
	MYOCD	MYOCD isoform 2. (986 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	DDX5	Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa)
	EPAS1	Endothelial PAS domain protein 1. (870 aa)
	MAML1	MAML1 isoform 1. (1016 aa)
	DDX17	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (735 aa)
	SDC1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
	HINFP	Histone H4 transcription factor. (518 aa)
	IGF1	Insulin-like growth factor 1 (Somatomedin C). (196 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (500 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	MAPK12	Mitogen-activated protein kinase. (370 aa)
	PLEKHM3	Pleckstrin homology domain containing, family M, member 3. (761 aa)
	TCF7L2	Transcription factor 7 like 2. (619 aa)
	MBNL1	Muscleblind like splicing regulator 1. (400 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	NRG1	NRG1 isoform 3. (713 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	LGALS1	Galectin. (135 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	MEGF10	MEGF10 isoform 2. (1140 aa)
	PITX1	Homeobox protein. (314 aa)
	SRF	Serum response factor (C-fos serum response element-binding transcription factor). (508 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
	TBXT	T-box transcription factor T. (435 aa)
	PLEC	PLEC isoform 2. (4684 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	REST	RE1 silencing transcription factor. (1097 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX17	DDX5	ENSPTRP00000062822	ENSPTRP00000016210	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...]	0.951
DDX17	MBNL1	ENSPTRP00000062822	ENSPTRP00000084465	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Muscleblind like splicing regulator 1.	0.541
DDX17	MYOD1	ENSPTRP00000062822	ENSPTRP00000005943	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.689
DDX5	DDX17	ENSPTRP00000016210	ENSPTRP00000062822	Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...]	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.951
DDX5	MBNL1	ENSPTRP00000016210	ENSPTRP00000084465	Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...]	Muscleblind like splicing regulator 1.	0.513
DDX5	MYOCD	ENSPTRP00000016210	ENSPTRP00000014974	Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...]	MYOCD isoform 2.	0.478
DDX5	MYOD1	ENSPTRP00000016210	ENSPTRP00000005943	Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...]	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.655
EPAS1	IGF1	ENSPTRP00000020413	ENSPTRP00000067917	Endothelial PAS domain protein 1.	Insulin-like growth factor 1 (Somatomedin C).	0.465
EPAS1	NOTCH1	ENSPTRP00000020413	ENSPTRP00000036924	Endothelial PAS domain protein 1.	NOTCH1 isoform 1.	0.640
FGF6	IGF1	ENSPTRP00000085321	ENSPTRP00000067917	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Insulin-like growth factor 1 (Somatomedin C).	0.655
FGF6	SDC1	ENSPTRP00000085321	ENSPTRP00000065998	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.677
FGF6	SHH	ENSPTRP00000085321	ENSPTRP00000075730	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.682
IGF1	EPAS1	ENSPTRP00000067917	ENSPTRP00000020413	Insulin-like growth factor 1 (Somatomedin C).	Endothelial PAS domain protein 1.	0.465
IGF1	FGF6	ENSPTRP00000067917	ENSPTRP00000085321	Insulin-like growth factor 1 (Somatomedin C).	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.655
IGF1	MYOD1	ENSPTRP00000067917	ENSPTRP00000005943	Insulin-like growth factor 1 (Somatomedin C).	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.487
IGF1	PLG	ENSPTRP00000067917	ENSPTRP00000032051	Insulin-like growth factor 1 (Somatomedin C).	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.452
IGF1	SDC1	ENSPTRP00000067917	ENSPTRP00000065998	Insulin-like growth factor 1 (Somatomedin C).	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.465
IGF1	SHH	ENSPTRP00000067917	ENSPTRP00000075730	Insulin-like growth factor 1 (Somatomedin C).	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.461
ISL1	SHH	ENSPTRP00000028882	ENSPTRP00000075730	ISL LIM homeobox 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.534
ISL1	TBX2	ENSPTRP00000028882	ENSPTRP00000016104	ISL LIM homeobox 1.	T-box transcription factor 2.	0.565