STRINGSTRING
LRRK1 LRRK1 PTK2B PTK2B SNX10 SNX10 ADRB2 ADRB2 PTH1R PTH1R IHH IHH ACP5 ACP5 RAB3D RAB3D TNFSF11 TNFSF11 IAPP IAPP TCIRG1 TCIRG1 TRAF6 TRAF6 PTH PTH TPP1 TPP1 EXT1 EXT1 CCDC154 CCDC154 CTNNB1 CTNNB1 NCDN NCDN ZNF675 ZNF675 NOX4 NOX4 ENSPTRP00000065244 ENSPTRP00000065244 SRC SRC IL7 IL7 HNF1A HNF1A CTSK CTSK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRRK1Leucine-rich repeat kinase 1. (2015 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
SNX10Sorting nexin 10. (201 aa)
ADRB2Adrenergic, beta-2-, receptor, surface. (429 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
RAB3DRAB3D, member RAS oncogene family. (219 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
IAPPIslet amyloid polypeptide. (89 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
TPP1Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). (563 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
CCDC154Coiled-coil domain containing 154. (522 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
NCDNNCDN isoform 2. (729 aa)
ZNF675ZNF675 isoform 4. (568 aa)
NOX4NADPH oxidase 4. (578 aa)
ENSPTRP00000065244annotation not available (463 aa)
SRCTyrosine-protein kinase. (542 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (179 aa)
HNF1AHNF1 homeobox A. (662 aa)
CTSKCTSK isoform 2; Belongs to the peptidase C1 family. (343 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.