STRINGSTRING
ID2 ID2 CMKLR1 CMKLR1 FNDC3B FNDC3B HNRNPU HNRNPU ENSPTRP00000084126 ENSPTRP00000084126 RORC RORC AKT1 AKT1 ZNF385A ZNF385A ENSPTRP00000082322 ENSPTRP00000082322 METRNL METRNL STK3 STK3 FERMT2 FERMT2 ENSPTRP00000080400 ENSPTRP00000080400 IL6-2 IL6-2 TGFB1I1 TGFB1I1 LOC750927 LOC750927 TPH1 TPH1 PPARG PPARG NOCT NOCT ZFPM2 ZFPM2 FLCN FLCN RUNX1T1 RUNX1T1 ENSPTRP00000074929 ENSPTRP00000074929 ENSPTRP00000074154 ENSPTRP00000074154 CREBL2 CREBL2 CREB1 CREB1 LEP LEP ID4 ID4 ASXL1 ASXL1 SIX1 SIX1 ENSPTRP00000069878 ENSPTRP00000069878 ZC3H12A ZC3H12A LRP5 LRP5 IL6 IL6 JDP2 JDP2 ZFP36L2 ZFP36L2 ALOX5 ALOX5 ARNTL ARNTL XBP1 XBP1 GATA3 GATA3 ENSPTRP00000064446 ENSPTRP00000064446 HES1 HES1 CCDC71L CCDC71L VSTM2A VSTM2A STK4 STK4 CK820_G0042363 CK820_G0042363 ZFP36L1 ZFP36L1 KLF5 KLF5 CDS1 CDS1 FNDC5 FNDC5 GATA2 GATA2 SFRP1 SFRP1 WNT3A WNT3A DLK2 DLK2 ENPP1 ENPP1 GNB3 GNB3 WWTR1 WWTR1 PPARD PPARD DDIT3 DDIT3 AXIN1 AXIN1 POTEA POTEA CARM1 CARM1 CCDC3 CCDC3 TFE3 TFE3 HDAC6 HDAC6 SYAP1 SYAP1 CCN4 CCN4 TMEM64 TMEM64 SNAI2 SNAI2 LPL LPL INSIG1 INSIG1 RARRES2 RARRES2 NAPEPLD NAPEPLD PIM1 PIM1 MAPK14 MAPK14 ATAT1 ATAT1 TRIO TRIO SFRP2 SFRP2 BBS12 BBS12 SULT1E1 SULT1E1 ADIPOQ ADIPOQ MMP11 MMP11 BMP7 BMP7 E2F1 E2F1 JAG1 JAG1 BMP2 BMP2 TRIB3 TRIB3 FRZB FRZB LOC735535 LOC735535 ASXL2 ASXL2 TRIB2 TRIB2 DKKL1 DKKL1 TRPM4 TRPM4 TGFB1 TGFB1 ZFP36 ZFP36 SIRT2 SIRT2 LRP3 LRP3 SIRT6 SIRT6 MEX3C MEX3C ZBTB7C ZBTB7C AXIN2 AXIN2 NR1D1 NR1D1 GPS2 GPS2 ZFPM1 ZFPM1 ENSPTRP00000013791 ENSPTRP00000013791 TLCD3B TLCD3B CK820_G0057069 CK820_G0057069 SAV1 SAV1 WDFY2 WDFY2 HTR2A HTR2A FOXO1 FOXO1 MEDAG MEDAG WIF1 WIF1 C1QL4 C1QL4 WNT1 WNT1 WNT10B WNT10B GDF3 GDF3 ZBTB16 ZBTB16 YAP1 YAP1 CCDC85B CCDC85B LGALS12 LGALS12 FFAR4 FFAR4 ADIRF ADIRF SIRT1 SIRT1 ANKRD30A ANKRD30A ANKRD26 ANKRD26 SOX13 SOX13 PTGS2 PTGS2 ZBTB7B ZBTB7B SORT1 SORT1 FTO FTO SIRT1-2 SIRT1-2 ADIG ADIG ENSPTRP00000091906 ENSPTRP00000091906 E2F1-2 E2F1-2 LOC101059671 LOC101059671 SMAD3 SMAD3 ENSPTRP00000089297 ENSPTRP00000089297 PTPRQ PTPRQ TAF8 TAF8 ENSPTRP00000087943 ENSPTRP00000087943 RORA RORA RARRES2-2 RARRES2-2 ZADH2 ZADH2 RREB1 RREB1 DUSP10 DUSP10 WNT5A WNT5A ENSPTRP00000085831 ENSPTRP00000085831 CEBPB CEBPB TRPV4 TRPV4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
CMKLR1Chemerin chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U (Scaffold attachment factor A). (825 aa)
ENSPTRP00000084126annotation not available (117 aa)
RORCRAR related orphan receptor C. (525 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
ZNF385AZinc finger protein 385A. (414 aa)
ENSPTRP00000082322annotation not available (82 aa)
METRNLMETRNL isoform 1. (273 aa)
STK3Serine/threonine kinase 3. (519 aa)
FERMT2Fermitin family member 2. (706 aa)
ENSPTRP00000080400Ankyrin repeat domain-containing protein 36C-like. (82 aa)
IL6-2Interleukin 6. (234 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (470 aa)
LOC750927CCDC144A isoform 2. (1267 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
NOCTCCR4 carbon catabolite repression 4-like. (431 aa)
ZFPM2ZFPM2 isoform 3. (1151 aa)
FLCNT0180863 isoform 1. (579 aa)
RUNX1T1RUNX1 translocation partner 1. (663 aa)
ENSPTRP00000074929annotation not available (367 aa)
ENSPTRP00000074154annotation not available (111 aa)
CREBL2cAMP-responsive element-binding protein-like 2. (193 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
ASXL1ASXL transcriptional regulator 1. (1548 aa)
SIX1SIX homeobox 1. (284 aa)
ENSPTRP00000069878annotation not available (125 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
JDP2Jun dimerization protein 2. (175 aa)
ZFP36L2Zinc finger protein 36, C3H type-like 2. (492 aa)
ALOX5ALOX5 isoform 2. (785 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like. (628 aa)
XBP1XBP1 isoform 4. (381 aa)
GATA3GATA binding protein 3. (444 aa)
ENSPTRP00000064446annotation not available (116 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
CCDC71LCCDC71L isoform 2. (311 aa)
VSTM2AV-set and transmembrane domain containing 2A. (309 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
KLF5Kruppel-like factor 5 (Intestinal). (457 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (461 aa)
FNDC5Fibronectin type III domain containing 5. (228 aa)
GATA2GATA binding protein 2. (480 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
DLK2Delta like non-canonical Notch ligand 2. (383 aa)
ENPP1ENPP1 isoform 1. (925 aa)
GNB3G protein subunit beta 3. (340 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
AXIN1AXIN1 isoform 2. (859 aa)
POTEAPOTEA isoform 1. (539 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (608 aa)
CCDC3Coiled-coil domain containing 3. (270 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (406 aa)
HDAC6Histone deacetylase 6. (146 aa)
SYAP1Synapse associated protein 1. (268 aa)
CCN4WISP1 isoform 1. (367 aa)
TMEM64Transmembrane protein 64. (380 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
RARRES2Retinoic acid receptor responder (Tazarotene induced) 2. (163 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (393 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (535 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
ATAT1Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (423 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3096 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
BBS12BBS12 isoform 1. (710 aa)
SULT1E1Sulfotransferase; Belongs to the sulfotransferase 1 family. (294 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
MMP11Matrix metallopeptidase 11 (Stromelysin 3). (489 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
E2F1E2F transcription factor 1. (437 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
TRIB3TRIB3 isoform 4. (386 aa)
FRZBFrizzled-related protein. (325 aa)
LOC735535POTE ankyrin domain family member F. (611 aa)
ASXL2ASXL transcriptional regulator 2. (1435 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
DKKL1Dickkopf like acrosomal protein 1. (242 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ZFP36Zinc finger protein 36, C3H type, homolog. (332 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
LRP3Low density lipoprotein receptor-related protein 3. (770 aa)
SIRT6SIRT6 isoform 1. (355 aa)
MEX3CMEX3C isoform 2. (639 aa)
ZBTB7CZinc finger and BTB domain containing 7C. (619 aa)
AXIN2AXIN2 isoform 1. (843 aa)
NR1D1Nuclear receptor subfamily 1, group D, member 1. (614 aa)
GPS2G protein pathway suppressor 2. (327 aa)
ZFPM1ZFPM1 isoform 1. (974 aa)
ENSPTRP00000013791Coiled-coil domain-containing protein 144A-like isoform X2. (314 aa)
TLCD3BFAM57B isoform 2. (274 aa)
CK820_G0057069POTEH isoform 1. (522 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
WDFY2WD repeat and FYVE domain containing 2. (400 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
FOXO1FOXO1 isoform 1. (655 aa)
MEDAGMesenteric estrogen dependent adipogenesis. (303 aa)
WIF1WNT inhibitory factor 1. (379 aa)
C1QL4Complement C1q like 4. (238 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
GDF3Growth differentiation factor 3. (364 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
YAP1Yes-associated protein 1. (508 aa)
CCDC85BCoiled-coil domain containing 85B. (202 aa)
LGALS12Galectin. (336 aa)
FFAR4Free fatty acid receptor 4. (377 aa)
ADIRFChromosome 10 open reading frame 116. (76 aa)
SIRT1SIRT1 isoform 2. (751 aa)
ANKRD30AANKRD30A isoform 2. (1470 aa)
ANKRD26Ankyrin repeat domain 26. (1711 aa)
SOX13SRY (Sex determining region Y)-box 13. (622 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
SORT1SORT1 isoform 2. (831 aa)
FTOFTO alpha-ketoglutarate dependent dioxygenase. (559 aa)
SIRT1-2Sirtuin 1. (751 aa)
ADIGADIG isoform 1. (80 aa)
ENSPTRP00000091906annotation not available (127 aa)
E2F1-2E2F transcription factor 1. (437 aa)
LOC101059671G protein pathway suppressor 2 pseudogene. (383 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
ENSPTRP00000089297annotation not available (265 aa)
PTPRQPTPRQ isoform 2. (2158 aa)
TAF8TATA-box binding protein associated factor 8. (338 aa)
ENSPTRP00000087943annotation not available (82 aa)
RORARAR-related orphan receptor A. (555 aa)
RARRES2-2Retinoic acid receptor responder 2. (163 aa)
ZADH2Zinc binding alcohol dehydrogenase domain containing 2. (377 aa)
RREB1Ras responsive element binding protein 1. (1742 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (488 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSPTRP00000085831annotation not available (79 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
TRPV4Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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