STRINGSTRING
VCL VCL FOXJ2 FOXJ2 ACVRL1 ACVRL1 BMP4 BMP4 CDH5 CDH5 VEZF1 VEZF1 CEACAM1 CEACAM1 XDH XDH IL1B IL1B PLCB1 PLCB1 JAG1 JAG1 ADD1 ADD1 BMP6 BMP6 IKBKB IKBKB ZDHHC21 ZDHHC21 NOTCH1 NOTCH1 CTNNB1 CTNNB1 APOLD1 APOLD1 S1PR3 S1PR3 NOTCH4 NOTCH4 ID1 ID1 TMEM100 TMEM100 BTG1 BTG1 F11R F11R ID1-2 ID1-2 ROCK1 ROCK1 BMP4-2 BMP4-2 TNF TNF GDF2 GDF2 ETV2 ETV2 ENSPTRP00000068511 ENSPTRP00000068511 ATOH8 ATOH8 TNFRSF1A TNFRSF1A PROC PROC ROCK2 ROCK2 LOC741150 LOC741150 ZEB1 ZEB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VCLVCL isoform 2. (1134 aa)
FOXJ2FOXJ2 isoform 1. (573 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CDH5CDH5 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
VEZF1Vascular endothelial zinc finger 1. (518 aa)
CEACAM1CEACAM1 isoform 3. (518 aa)
XDHXDH isoform 1. (1333 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ADD1ADD1 isoform 5. (768 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
APOLD1Apolipoprotein L domain containing 1. (279 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (350 aa)
NOTCH4NOTCH4 isoform 3. (2006 aa)
ID1Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein. (155 aa)
TMEM100Transmembrane protein 100. (134 aa)
BTG1B-cell translocation gene 1, anti-proliferative. (171 aa)
F11RF11R isoform 1. (322 aa)
ID1-2Inhibitor of DNA binding 1, HLH protein. (155 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
GDF2GDF2 isoform 1. (429 aa)
ETV2ETV2 isoform 5. (370 aa)
ENSPTRP00000068511annotation not available (353 aa)
ATOH8Atonal bHLH transcription factor 8. (323 aa)
TNFRSF1ATumor necrosis factor receptor superfamily, member 1A. (455 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa. (495 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
LOC741150Vascular endothelial zinc finger 1 pseudogene. (442 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.