26 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ETV4	ETV4 isoform 3. (484 aa)
	NCOA3	Nuclear receptor coactivator. (1426 aa)
	H2AFY	H2AFY isoform 4. (372 aa)
	SFRP4	SFRP4 isoform 1. (368 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	PLAAT4	RARRES3 isoform 3. (164 aa)
	SULT2B1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (365 aa)
	ATOH1	Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). (356 aa)
	KDF1	Keratinocyte differentiation factor 1. (398 aa)
	IL20	IL20 isoform 1. (176 aa)
	H2AFY2	H2AFY2 isoform 1. (372 aa)
	SFN	SFN isoform 1; Belongs to the 14-3-3 family. (248 aa)
	NUMA1	Nuclear mitotic apparatus protein 1. (2111 aa)
	OVOL2	Ovo like zinc finger 2. (275 aa)
	PTCH1	PTCH1 isoform 8. (1428 aa)
	VDR	Vitamin D (1,25-dihydroxyvitamin D3) receptor. (477 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	ZBED2	Zinc finger BED-type containing 2. (218 aa)
	PTCH2	PTCH2 isoform 3. (1203 aa)
	FOXC1	FOXC1 isoform 1. (550 aa)
	TRIM16	T0195358 isoform 1. (564 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	ALOX15B	Arachidonate 15-lipoxygenase, type B. (676 aa)
	TRIM16-2	Tripartite motif containing 16. (560 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOH1	NOTCH1	ENSPTRP00000053413	ENSPTRP00000036924	Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).	NOTCH1 isoform 1.	0.472
BMP4	FOXC1	ENSPTRP00000010780	ENSPTRP00000065226	Bone morphogenetic protein 4.	FOXC1 isoform 1.	0.480
BMP4	PTCH1	ENSPTRP00000010780	ENSPTRP00000087586	Bone morphogenetic protein 4.	PTCH1 isoform 8.	0.454
BMP4-2	FOXC1	ENSPTRP00000080656	ENSPTRP00000065226	Bone morphogenetic protein 4.	FOXC1 isoform 1.	0.480
BMP4-2	PTCH1	ENSPTRP00000080656	ENSPTRP00000087586	Bone morphogenetic protein 4.	PTCH1 isoform 8.	0.454
CYP27B1	MED1	ENSPTRP00000008760	ENSPTRP00000015490	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.855
CYP27B1	NCOA3	ENSPTRP00000008760	ENSPTRP00000023375	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Nuclear receptor coactivator.	0.792
CYP27B1	VDR	ENSPTRP00000008760	ENSPTRP00000084220	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Vitamin D (1,25-dihydroxyvitamin D3) receptor.	0.612
ETV4	NCOA3	ENSPTRP00000015737	ENSPTRP00000023375	ETV4 isoform 3.	Nuclear receptor coactivator.	0.939
FOXC1	BMP4	ENSPTRP00000065226	ENSPTRP00000010780	FOXC1 isoform 1.	Bone morphogenetic protein 4.	0.480
FOXC1	BMP4-2	ENSPTRP00000065226	ENSPTRP00000080656	FOXC1 isoform 1.	Bone morphogenetic protein 4.	0.480
MED1	CYP27B1	ENSPTRP00000015490	ENSPTRP00000008760	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	0.855
MED1	NCOA3	ENSPTRP00000015490	ENSPTRP00000023375	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor coactivator.	0.975
MED1	VDR	ENSPTRP00000015490	ENSPTRP00000084220	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Vitamin D (1,25-dihydroxyvitamin D3) receptor.	0.841
NCOA3	CYP27B1	ENSPTRP00000023375	ENSPTRP00000008760	Nuclear receptor coactivator.	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	0.792
NCOA3	ETV4	ENSPTRP00000023375	ENSPTRP00000015737	Nuclear receptor coactivator.	ETV4 isoform 3.	0.939
NCOA3	MED1	ENSPTRP00000023375	ENSPTRP00000015490	Nuclear receptor coactivator.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.975
NCOA3	VDR	ENSPTRP00000023375	ENSPTRP00000084220	Nuclear receptor coactivator.	Vitamin D (1,25-dihydroxyvitamin D3) receptor.	0.793
NOTCH1	ATOH1	ENSPTRP00000036924	ENSPTRP00000053413	NOTCH1 isoform 1.	Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).	0.472
NOTCH1	TRIM16	ENSPTRP00000036924	ENSPTRP00000061445	NOTCH1 isoform 1.	T0195358 isoform 1.	0.440