STRINGSTRING
JAK3 JAK3 NRARP NRARP FGL2 FGL2 INHBA INHBA RUNX1 RUNX1 ENSPTRP00000092837 ENSPTRP00000092837 FGL2-2 FGL2-2 MDK MDK ENSPTRP00000084126 ENSPTRP00000084126 ENSPTRP00000082165 ENSPTRP00000082165 ENSPTRP00000081289 ENSPTRP00000081289 BMP4-2 BMP4-2 TNFSF18 TNFSF18 CTLA4 CTLA4 CDKN2A CDKN2A ENSPTRP00000076473 ENSPTRP00000076473 SHH SHH LOXL3 LOXL3 ENSPTRP00000073371 ENSPTRP00000073371 PTPN2 PTPN2 LOC471771 LOC471771 IL4-2 IL4-2 LILRB4 LILRB4 ERBB2 ERBB2 LOC468520 LOC468520 ZC3H12A ZC3H12A ENSPTRP00000068326 ENSPTRP00000068326 BCL6 BCL6 ENSPTRP00000066724 ENSPTRP00000066724 HMGB3 HMGB3 ENSPTRP00000062050 ENSPTRP00000062050 SOCS5 SOCS5 CBFB CBFB SFRP1 SFRP1 ANXA1 ANXA1 CD74 CD74 RUNX3 RUNX3 PGLYRP3 PGLYRP3 ZBTB7B ZBTB7B TNFSF4 TNFSF4 RC3H1 RC3H1 HLX HLX RAG2 RAG2 BMP4 BMP4 SOCS1 SOCS1 IL4R IL4R TBX21 TBX21 FOXJ1 FOXJ1 SMAD7 SMAD7 CLEC4G CLEC4G PRDX2 PRDX2 PGLYRP2 PGLYRP2 IFNL1 IFNL1 PGLYRP1 PGLYRP1 ID2 ID2 ZC3H8 ZC3H8 IHH IHH INHA INHA FBXO7 FBXO7 IL2 IL2 TMEM131L TMEM131L IRF1 IRF1 IL4 IL4 GLI3 GLI3 IFNB1 IFNB1 RC3H2 RC3H2 FOXP3 FOXP3 LAG3 LAG3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK3Tyrosine-protein kinase. (1124 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
FGL2Fibrinogen-like 2. (439 aa)
INHBAInhibin subunit beta A. (426 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
ENSPTRP00000092837annotation not available (325 aa)
FGL2-2Fibrinogen like 2. (439 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
ENSPTRP00000084126annotation not available (117 aa)
ENSPTRP00000082165annotation not available (192 aa)
ENSPTRP00000081289annotation not available (192 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
TNFSF18Tumor necrosis factor ligand 2A. (199 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
ENSPTRP00000076473annotation not available (202 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
LOXL3Lysyl oxidase-like 3. (753 aa)
ENSPTRP00000073371annotation not available (431 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (421 aa)
LOC471771High mobility group protein B3-like isoform X1. (178 aa)
IL4-2Interleukin 4. (153 aa)
LILRB4LILRB4 isoform 7. (449 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
LOC468520Zinc finger protein 271. (672 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
ENSPTRP00000068326annotation not available (488 aa)
BCL6BCL6 transcription repressor. (706 aa)
ENSPTRP00000066724annotation not available (166 aa)
HMGB3High mobility group box 3. (207 aa)
ENSPTRP00000062050annotation not available (183 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
CBFBCore-binding factor, beta subunit. (182 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
CD74CD74 isoform 5. (296 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
PGLYRP3PGLYRP3 isoform 1. (341 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa)
RC3H1Ring finger and CCCH-type domains 1. (1134 aa)
HLXH2.0-like homeobox. (493 aa)
RAG2Recombination activating 2. (527 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
IL4RIL4R isoform 2. (827 aa)
TBX21T-box transcription factor 21. (535 aa)
FOXJ1FOXJ1 isoform 1. (421 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
PRDX2PRDX2 isoform 1. (198 aa)
PGLYRP2Peptidoglycan recognition protein 2. (634 aa)
IFNL1Interferon lambda 1. (200 aa)
PGLYRP1Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (196 aa)
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
ZC3H8Zinc finger CCCH-type containing 8. (291 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
FBXO7F-box protein 7. (522 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
TMEM131LTMEM131L isoform 3. (1617 aa)
IRF1Interferon regulatory factor. (325 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
IFNB1Interferon beta 1. (187 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
FOXP3FOXP3 isoform 4. (456 aa)
LAG3LAG3 isoform 3. (527 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: medium (44%) [HD]