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| | RUNX3 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa) |
| | ZBTB7B | Zinc finger and BTB domain containing 7B. (573 aa) |
| | TNFSF4 | Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1306 aa) |
| | SOX13 | SRY (Sex determining region Y)-box 13. (622 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | HLX | H2.0-like homeobox. (493 aa) |
| | ITPKB | Kinase; Belongs to the inositol phosphokinase (IPK) family. (946 aa) |
| | NLRP3 | NLRP3 isoform 2. (1025 aa) |
| | ZMIZ1 | Zinc finger, MIZ-type containing 1. (1073 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) |
| | SART1 | Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (800 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | ZBTB16 | Zinc finger and BTB domain containing 16. (673 aa) |
| | ARID2 | AT-rich interaction domain 2. (1835 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | NCKAP1L | NCK associated protein 1 like. (1127 aa) |
| | TESPA1 | TESPA1 isoform 6. (521 aa) |
| | IL23A | Interleukin 23 subunit alpha. (189 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa) |
| | PCID2-2 | PCI domain-containing protein 2. (399 aa) |
| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | MMP14 | Matrix metallopeptidase 14. (582 aa) |
| | PPP2R3C | Protein phosphatase 2, regulatory subunit B'', gamma. (453 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (211 aa) |
| | IL4R | IL4R isoform 2. (827 aa) |
| | SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (531 aa) |
| | MALT1 | Mucosa associated lymphoid tissue lymphoma translocation gene 1. (824 aa) |
| | AP3D1 | AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1215 aa) |
| | NFKBID | NFKB inhibitor delta. (465 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | ZAP70 | Tyrosine-protein kinase. (619 aa) |
| | IL1RL2 | IL1RL2 isoform 1. (595 aa) |
| | IHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa) |
| | INPP5D | Inositol polyphosphate-5-phosphatase D. (1189 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (622 aa) |
| | SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1. (1105 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | NFKBIZ | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta. (718 aa) |
| | CD80 | CD80 isoform 1. (288 aa) |
| | CD86 | CD86 isoform 3. (329 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa) |
| | AP3B1 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1045 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) |
| | CD83 | CD83 isoform 2. (205 aa) |
| | PATR-DRA | MHC class II protein; Belongs to the MHC class II family. (254 aa) |
| | VNN1 | VNN1 isoform 1. (513 aa) |
| | VNN3 | VNN3 isoform 1. (501 aa) |
| | MYB | MYB proto-oncogene, transcription factor. (761 aa) |
| | PHF10 | PHD finger protein 10. (498 aa) |
| | GLI3 | Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa) |
| | ACTL6B | ACTL6B isoform 1; Belongs to the actin family. (426 aa) |
| | SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa) |
| | EGR3 | Early growth response 3. (387 aa) |
| | TOX | Thymocyte selection-associated high mobility group box. (526 aa) |
| | CCL19 | C-C motif chemokine. (98 aa) |
| | FOXP3 | FOXP3 isoform 4. (456 aa) |
| | BTK | BTK isoform 2. (693 aa) |
| | VSIR | Chromosome 10 open reading frame 54. (311 aa) |
| | SASH3 | SAM and SH3 domain containing 3. (380 aa) |
| | GLI2 | GLI family zinc finger 2. (1587 aa) |
| | SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (394 aa) |
| | PBRM1 | PBRM1 isoform 17. (1690 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic polypeptide; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | IL12RB1 | IL12RB1 isoform 1. (662 aa) |
| | NKAP | NFKB activating protein. (415 aa) |
| | IL2RG | IL2RG isoform 1. (369 aa) |
| | GIMAP1 | GTPase IMAP family member 5. (500 aa) |
| | CD74 | CD74 isoform 5. (296 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa) |
| | SHB | Src homology 2 domain containing adaptor protein B. (509 aa) |
| | CD27 | CD27 isoform 1. (260 aa) |
| | SOX4 | Transcription factor SOX. (474 aa) |
| | SOX12 | Transcription factor SOX. (316 aa) |
| | RARA | RARA isoform 4. (624 aa) |
| | IL4I1 | Amine oxidase. (589 aa) |
| | PATR-G | Patr class I histocompatibility antigen, alpha chain G; Involved in the presentation of foreign antigens to the immune system. (371 aa) |
| | ENSPTRP00000056956 | annotation not available (225 aa) |
| | ZBTB1 | Zinc finger and BTB domain containing 1. (676 aa) |
| | CBFB | Core-binding factor, beta subunit. (182 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5. (536 aa) |
| | ENSPTRP00000061537 | annotation not available (357 aa) |
| | SMARCA2 | SMARCA2 isoform 11. (1588 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (955 aa) |
| | BTN2A2 | Butyrophilin subfamily 2 member A2. (532 aa) |
| | ACTL6B-2 | Actin like 6B. (426 aa) |
| | GATA3 | GATA binding protein 3. (444 aa) |
| | ADAM8 | ADAM metallopeptidase domain 8. (824 aa) |
| | XBP1 | XBP1 isoform 4. (381 aa) |
| | SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa) |
| | IL15 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | BCL6 | BCL6 transcription repressor. (706 aa) |
| | ENSPTRP00000068326 | annotation not available (488 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa) |
| | IL23R | IL23R isoform 1. (629 aa) |
| | ENSPTRP00000071088 | annotation not available (500 aa) |
| | LILRB4 | LILRB4 isoform 7. (449 aa) |
| | SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa) |
| | IL4-2 | Interleukin 4. (153 aa) |
| | ENSPTRP00000072507 | annotation not available (659 aa) |
| | ACTL6A | ACTL6A isoform 2; Belongs to the actin family. (430 aa) |
| | RASGRP1 | RASGRP1 isoform 4. (848 aa) |
| | ENSPTRP00000073097 | annotation not available (202 aa) |
| | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa) |
| | XRCC6-2 | X-ray repair complementing defective repair in Chinese hamster cells 6. (609 aa) |
| | ENSPTRP00000073371 | annotation not available (431 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (609 aa) |
| | ADA | Adenosine deaminase. (412 aa) |
| | IL15RA | IL15RA isoform 11. (353 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | ENSPTRP00000074974 | annotation not available (225 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa) |
| | IL7R | Interleukin 7 receptor. (459 aa) |
| | ENSPTRP00000076005 | annotation not available (354 aa) |
| | TNFSF9 | TNF superfamily member 9; Belongs to the tumor necrosis factor family. (253 aa) |
| | ENSPTRP00000076931 | annotation not available (350 aa) |
| | SMARCD3-2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa) |
| | CK820_G0040570 | PRKCZ isoform 2. (457 aa) |
| | IL7 | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (179 aa) |
| | ARID1B | ARID1B isoform 2. (2422 aa) |
| | LOC460817 | Bromodomain-containing protein 7 pseudogene. (397 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (414 aa) |
| | CD46 | CD46 isoform 5. (432 aa) |
| | BRD7 | Bromodomain containing 7. (652 aa) |
| | PIK3R6 | Phosphoinositide-3-kinase regulatory subunit 6. (754 aa) |
| | SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1245 aa) |
| | PCID2 | PCI domain containing 2. (398 aa) |
| | MDK | Midkine (Neurite growth-promoting factor 2). (143 aa) |
| | DUSP10 | Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (488 aa) |
| | ENSPTRP00000086328 | annotation not available (580 aa) |
| | ARID1A | AT rich interactive domain 1A (SWI-like). (2287 aa) |
| | AMBRA1 | AMBRA1 isoform 6. (1298 aa) |
| | AXL | AXL receptor tyrosine kinase. (894 aa) |
| | LGALS9 | Galectin. (355 aa) |
| | CK820_G0040570-2 | PRKCZ isoform 4. (95 aa) |
| | STAT5B | Signal transducer and activator of transcription. (772 aa) |
| | RHOH | RHOH isoform 10. (191 aa) |
| | RUNX1 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa) |
| | ENSPTRP00000093159 | annotation not available (532 aa) |
| | BAD | Bcl2-associated agonist of cell death. (168 aa) |
