(24 nodes) Positive regulation of T-helper cell differentiation network (Pan troglodytes)

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Your Input:
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	CK820_G0040570-2	PRKCZ isoform 4. (95 aa)
	CK820_G0040570	PRKCZ isoform 2. (457 aa)
	ENSPTRP00000073371	annotation not available (431 aa)
	IL23R	IL23R isoform 1. (629 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	RARA	RARA isoform 4. (624 aa)
	SHB	Src homology 2 domain containing adaptor protein B. (509 aa)
	ANXA1	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
	IL12RB1	IL12RB1 isoform 1. (662 aa)
	CCL19	C-C motif chemokine. (98 aa)
	MYB	MYB proto-oncogene, transcription factor. (761 aa)
	CD86	CD86 isoform 3. (329 aa)
	CD80	CD80 isoform 1. (288 aa)
	NFKBIZ	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta. (718 aa)
	NFKBID	NFKB inhibitor delta. (465 aa)
	MALT1	Mucosa associated lymphoid tissue lymphoma translocation gene 1. (824 aa)
	IL4R	IL4R isoform 2. (827 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	NLRP3	NLRP3 isoform 2. (1025 aa)
	HLX	H2.0-like homeobox. (493 aa)
	TNFSF4	Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL19	CD80	ENSPTRP00000035734	ENSPTRP00000026304	C-C motif chemokine.	CD80 isoform 1.	0.513
CD80	CCL19	ENSPTRP00000026304	ENSPTRP00000035734	CD80 isoform 1.	C-C motif chemokine.	0.513
CD80	CD86	ENSPTRP00000026304	ENSPTRP00000026356	CD80 isoform 1.	CD86 isoform 3.	0.998
CD80	IL12B	ENSPTRP00000026304	ENSPTRP00000029869	CD80 isoform 1.	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	0.400
CD80	IL18	ENSPTRP00000026304	ENSPTRP00000007359	CD80 isoform 1.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.511
CD80	IL4R	ENSPTRP00000026304	ENSPTRP00000013524	CD80 isoform 1.	IL4R isoform 2.	0.446
CD80	TNFSF4	ENSPTRP00000026304	ENSPTRP00000002818	CD80 isoform 1.	Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family.	0.659
CD86	CD80	ENSPTRP00000026356	ENSPTRP00000026304	CD86 isoform 3.	CD80 isoform 1.	0.998
CD86	IL18	ENSPTRP00000026356	ENSPTRP00000007359	CD86 isoform 3.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.536
CD86	IL23R	ENSPTRP00000026356	ENSPTRP00000070352	CD86 isoform 3.	IL23R isoform 1.	0.406
CD86	IL4R	ENSPTRP00000026356	ENSPTRP00000013524	CD86 isoform 3.	IL4R isoform 2.	0.592
CD86	TNFSF4	ENSPTRP00000026356	ENSPTRP00000002818	CD86 isoform 3.	Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family.	0.558
ENSPTRP00000073371	IL4R	ENSPTRP00000073371	ENSPTRP00000013524	annotation not available	IL4R isoform 2.	0.678
ENSPTRP00000073371	SOCS5	ENSPTRP00000073371	ENSPTRP00000061344	annotation not available	Suppressor of cytokine signaling 5.	0.545
IL12B	CD80	ENSPTRP00000029869	ENSPTRP00000026304	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	CD80 isoform 1.	0.400
IL12B	IL12RB1	ENSPTRP00000029869	ENSPTRP00000046039	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	IL12RB1 isoform 1.	0.995
IL12B	IL18	ENSPTRP00000029869	ENSPTRP00000007359	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.418
IL12B	IL23A	ENSPTRP00000029869	ENSPTRP00000008668	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin 23 subunit alpha.	0.998
IL12B	IL23R	ENSPTRP00000029869	ENSPTRP00000070352	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	IL23R isoform 1.	0.977
IL12B	IL4R	ENSPTRP00000029869	ENSPTRP00000013524	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	IL4R isoform 2.	0.671