STRINGSTRING
BMP6 BMP6 TP63 TP63 LTF LTF LIMD1 LIMD1 ATF4 ATF4 BMP7 BMP7 JAG1 JAG1 BMP2 BMP2 RASSF2 RASSF2 NPPC NPPC IGFBP5 IGFBP5 ACVR2A ACVR2A ATRAID ATRAID TRPM4 TRPM4 LRP3 LRP3 PRKACA PRKACA TWSG1 TWSG1 SOX9 SOX9 AXIN2 AXIN2 DDX5 DDX5 NOG NOG SMAD6 SMAD6 SMOC1 SMOC1 BMP4 BMP4 PRKD1 PRKD1 WNT10B WNT10B FGF23 FGF23 YAP1 YAP1 TCIRG1 TCIRG1 MEN1 MEN1 ESRRA ESRRA NELL1 NELL1 FGFR2 FGFR2 FFAR4 FFAR4 BMPR1A BMPR1A BAMBI BAMBI UCMA UCMA TNN TNN DDR2 DDR2 IL6R IL6R CCN1 CCN1 ID3 ID3 SKI SKI SOX11 SOX11 GREM2 GREM2 SMAD3 SMAD3 MEF2C MEF2C CRIM1 CRIM1 SUCO SUCO HDAC7 HDAC7 PTCH1 PTCH1 ENSPTRP00000087425 ENSPTRP00000087425 ZHX3 ZHX3 ENSPTRP00000086525 ENSPTRP00000086525 NPNT NPNT CHRD CHRD RANBP3L RANBP3L CEBPB CEBPB FNDC3B FNDC3B PTK2 PTK2 SCUBE2 SCUBE2 ENSPTRP00000082975 ENSPTRP00000082975 ENSPTRP00000082515 ENSPTRP00000082515 FERMT2 FERMT2 BMP4-2 BMP4-2 IL6-2 IL6-2 SMAD5 SMAD5 FBN2 FBN2 PDLIM7 PDLIM7 LOC100612565 LOC100612565 CTNNBIP1 CTNNBIP1 GLI1 GLI1 JUND JUND ACVR2B ACVR2B ENSPTRP00000077036 ENSPTRP00000077036 PPARG PPARG ACVR1 ACVR1 NOCT NOCT SUFU SUFU HGF HGF TMEM119 TMEM119 GDPD2 GDPD2 ENSPTRP00000071105 ENSPTRP00000071105 TNF TNF LOC100611078 LOC100611078 NBR1 NBR1 LRP5 LRP5 IL6 IL6 IGF1 IGF1 PPP3CA PPP3CA ILK ILK RUNX2 RUNX2 TENT5A TENT5A IL6ST IL6ST ENSPTRP00000064416 ENSPTRP00000064416 WNT7B WNT7B WNT4 WNT4 LOC104003639 LOC104003639 CK820_G0042363 CK820_G0042363 AREG AREG CEBPD CEBPD RORB RORB SCUBE3 SCUBE3 SFRP1 SFRP1 HAND2 HAND2 SEMA4D SEMA4D TNFAIP6 TNFAIP6 BMPR2 BMPR2 IFITM1 IFITM1 TWIST1 TWIST1 WWTR1 WWTR1 CTNNB1 CTNNB1 WDR63 WDR63 GDF10 GDF10 REST REST CITED1 CITED1 NOTCH1 NOTCH1 HEMGN HEMGN CCN4 CCN4 CTHRC1 CTHRC1 TMEM64 TMEM64 SNAI2 SNAI2 CDK6 CDK6 GLI3 GLI3 HOXA2 HOXA2 FBXO5 FBXO5 CLIC1 CLIC1 VEGFC VEGFC SFRP2 SFRP2 SMAD1 SMAD1 BMPR1B BMPR1B OSTN OSTN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP6Bone morphogenetic protein 6. (512 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
LIMD1LIM domains containing 1. (676 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
RASSF2Ras association (RalGDS/AF-6) domain family member 2. (326 aa)
NPPCNatriuretic peptide C. (126 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (284 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
LRP3Low density lipoprotein receptor-related protein 3. (770 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
AXIN2AXIN2 isoform 1. (843 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
SMOC1SPARC related modular calcium binding 1. (435 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (873 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
YAP1Yes-associated protein 1. (508 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
MEN1MEN1 isoform 14. (615 aa)
ESRRAEstrogen-related receptor alpha. (422 aa)
NELL1Neural EGFL like 1. (838 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
FFAR4Free fatty acid receptor 4. (377 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
UCMAUCMA isoform 1. (138 aa)
TNNTNN isoform 1. (1299 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
IL6RInterleukin 6 receptor. (442 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
ID3Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein. (119 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
SOX11Transcription factor SOX. (441 aa)
GREM2Gremlin. (168 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
CRIM1CRIM1 isoform 1. (1036 aa)
SUCOSUCO isoform 1. (1395 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
ENSPTRP00000087425annotation not available (336 aa)
ZHX3Zinc fingers and homeoboxes 3. (965 aa)
ENSPTRP00000086525annotation not available (336 aa)
NPNTNPNT isoform 10. (611 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
RANBP3LRAN binding protein 3 like. (490 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
SCUBE2SCUBE2 isoform 2. (996 aa)
ENSPTRP00000082975annotation not available (212 aa)
ENSPTRP00000082515annotation not available (336 aa)
FERMT2Fermitin family member 2. (706 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
IL6-2Interleukin 6. (234 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
FBN2FBN2 isoform 1. (2912 aa)
PDLIM7PDZ and LIM domain 7 (Enigma). (459 aa)
LOC100612565Steroid hormone receptor ERR1 pseudogene. (396 aa)
CTNNBIP1Catenin, beta interacting protein 1. (81 aa)
GLI1GLI family zinc finger 1. (1106 aa)
JUNDJUND isoform 1. (346 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
ENSPTRP00000077036annotation not available (396 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
NOCTCCR4 carbon catabolite repression 4-like. (431 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
TMEM119Transmembrane protein 119. (283 aa)
GDPD2Glycerophosphodiester phosphodiesterase domain containing 2. (590 aa)
ENSPTRP00000071105annotation not available (376 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
LOC100611078Cyclic AMP-dependent transcription factor ATF-4 pseudogene. (318 aa)
NBR1NBR1 isoform 1. (985 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ILKIntegrin-linked kinase. (533 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
TENT5ATerminal nucleotidyltransferase 5A. (452 aa)
IL6STInterleukin 6 signal transducer (Gp130, oncostatin M receptor). (918 aa)
ENSPTRP00000064416annotation not available (502 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
AREGAREG isoform 2. (274 aa)
CEBPDCCAAT/enhancer-binding protein. (269 aa)
RORBRAR related orphan receptor B. (482 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (993 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SEMA4DSEMA4D isoform 13; Belongs to the semaphorin family. (862 aa)
TNFAIP6Tumor necrosis factor, alpha-induced protein 6. (277 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
IFITM1IFITM2 isoform 1. (125 aa)
TWIST1TWIST1 isoform 2. (163 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
WDR63WDR63 isoform 3. (857 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
RESTRE1 silencing transcription factor. (1097 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
HEMGNHEMGN isoform 1. (484 aa)
CCN4WISP1 isoform 1. (367 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
TMEM64Transmembrane protein 64. (380 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
HOXA2HOXA2 isoform 1. (376 aa)
FBXO5F-box protein 5. (447 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
OSTNOSTN isoform 2. (133 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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