STRINGSTRING
SKI SKI ID3 ID3 TNN TNN UCMA UCMA BAMBI BAMBI MEN1 MEN1 FGF23 FGF23 SMAD6 SMAD6 NOG NOG AXIN2 AXIN2 SOX9 SOX9 TWSG1 TWSG1 TRPM4 TRPM4 IGFBP5 IGFBP5 LIMD1 LIMD1 VEGFC VEGFC HOXA2 HOXA2 CDK6 CDK6 TMEM64 TMEM64 NOTCH1 NOTCH1 CITED1 CITED1 GDF10 GDF10 TWIST1 TWIST1 TNFAIP6 TNFAIP6 SEMA4D SEMA4D HAND2 HAND2 SFRP1 SFRP1 RORB RORB AREG AREG CK820_G0042363 CK820_G0042363 LRP5 LRP5 NBR1 NBR1 TNF TNF ENSPTRP00000071105 ENSPTRP00000071105 SUFU SUFU NOCT NOCT PPARG PPARG FNDC3B FNDC3B RANBP3L RANBP3L CHRD CHRD PTCH1 PTCH1 HDAC7 HDAC7 CRIM1 CRIM1 SMAD3 SMAD3 GREM2 GREM2 OSTN OSTN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
ID3Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein. (119 aa)
TNNTNN isoform 1. (1299 aa)
UCMAUCMA isoform 1. (138 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
MEN1MEN1 isoform 14. (615 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
AXIN2AXIN2 isoform 1. (843 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
LIMD1LIM domains containing 1. (676 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
HOXA2HOXA2 isoform 1. (376 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
TMEM64Transmembrane protein 64. (380 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
TWIST1TWIST1 isoform 2. (163 aa)
TNFAIP6Tumor necrosis factor, alpha-induced protein 6. (277 aa)
SEMA4DSEMA4D isoform 13; Belongs to the semaphorin family. (862 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
RORBRAR related orphan receptor B. (482 aa)
AREGAREG isoform 2. (274 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
NBR1NBR1 isoform 1. (985 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
ENSPTRP00000071105annotation not available (376 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
NOCTCCR4 carbon catabolite repression 4-like. (431 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
RANBP3LRAN binding protein 3 like. (490 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
CRIM1CRIM1 isoform 1. (1036 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
GREM2Gremlin. (168 aa)
OSTNOSTN isoform 2. (133 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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