STRINGSTRING
ENSPTRP00000082975 ENSPTRP00000082975 FERMT2 FERMT2 BMP4-2 BMP4-2 IL6-2 IL6-2 SMAD5 SMAD5 PDLIM7 PDLIM7 CTNNBIP1 CTNNBIP1 JUND JUND ACVR2B ACVR2B ACVR1 ACVR1 HGF HGF TMEM119 TMEM119 GDPD2 GDPD2 LRP5 LRP5 IL6 IL6 IGF1 IGF1 PPP3CA PPP3CA ILK ILK RUNX2 RUNX2 TENT5A TENT5A IL6ST IL6ST ENSPTRP00000064416 ENSPTRP00000064416 WNT7B WNT7B WNT4 WNT4 LOC104003639 LOC104003639 CEBPD CEBPD SCUBE3 SCUBE3 BMPR2 BMPR2 IFITM1 IFITM1 WWTR1 WWTR1 CTNNB1 CTNNB1 WDR63 WDR63 GDF10 GDF10 CCN4 CCN4 CTHRC1 CTHRC1 GLI3 GLI3 FBXO5 FBXO5 CLIC1 CLIC1 BMP6 BMP6 SFRP2 SFRP2 SMAD1 SMAD1 BMPR1B BMPR1B TP63 TP63 LTF LTF BMP7 BMP7 JAG1 JAG1 BMP2 BMP2 NPPC NPPC ATRAID ATRAID CCN1 CCN1 IL6R IL6R DDR2 DDR2 BMPR1A BMPR1A ACVR2A ACVR2A FFAR4 FFAR4 NELL1 NELL1 YAP1 YAP1 WNT10B WNT10B PRKD1 PRKD1 BMP4 BMP4 LRP3 LRP3 SCUBE2 SCUBE2 CEBPB CEBPB NPNT NPNT ZHX3 ZHX3 SUCO SUCO MEF2C MEF2C SOX11 SOX11 FBN2 FBN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPTRP00000082975annotation not available (212 aa)
FERMT2Fermitin family member 2. (706 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
IL6-2Interleukin 6. (234 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PDLIM7PDZ and LIM domain 7 (Enigma). (459 aa)
CTNNBIP1Catenin, beta interacting protein 1. (81 aa)
JUNDJUND isoform 1. (346 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
TMEM119Transmembrane protein 119. (283 aa)
GDPD2Glycerophosphodiester phosphodiesterase domain containing 2. (590 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ILKIntegrin-linked kinase. (533 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
TENT5ATerminal nucleotidyltransferase 5A. (452 aa)
IL6STInterleukin 6 signal transducer (Gp130, oncostatin M receptor). (918 aa)
ENSPTRP00000064416annotation not available (502 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
CEBPDCCAAT/enhancer-binding protein. (269 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (993 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
IFITM1IFITM2 isoform 1. (125 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
WDR63WDR63 isoform 3. (857 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
CCN4WISP1 isoform 1. (367 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
FBXO5F-box protein 5. (447 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
NPPCNatriuretic peptide C. (126 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (284 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
IL6RInterleukin 6 receptor. (442 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
FFAR4Free fatty acid receptor 4. (377 aa)
NELL1Neural EGFL like 1. (838 aa)
YAP1Yes-associated protein 1. (508 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (873 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
LRP3Low density lipoprotein receptor-related protein 3. (770 aa)
SCUBE2SCUBE2 isoform 2. (996 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
NPNTNPNT isoform 10. (611 aa)
ZHX3Zinc fingers and homeoboxes 3. (965 aa)
SUCOSUCO isoform 1. (1395 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SOX11Transcription factor SOX. (441 aa)
FBN2FBN2 isoform 1. (2912 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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