47 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
	RNF112	Ring finger protein 112. (631 aa)
	ENSPTRP00000079007	annotation not available (323 aa)
	PTN	PTN isoform 2. (172 aa)
	NKX6-2	NKX6-2 isoform 1. (276 aa)
	EGR2	Early growth response 2. (476 aa)
	TNFRSF1B	Tumor necrosis factor receptor superfamily, member 1B. (461 aa)
	HDAC2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
	CD22-2	B-cell receptor CD22. (626 aa)
	PTPRZ1	Protein tyrosine phosphatase receptor type Z1. (2315 aa)
	DICER1	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	IL33	IL33 isoform 1. (270 aa)
	NKX6-1	NKX6-1 isoform 2. (367 aa)
	GSX2	GSX2 isoform 2. (304 aa)
	DAG1	Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
	LIF	Leukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
	IL34	IL34 isoform 1. (242 aa)
	ASPA	Aspartoacylase (Canavan disease). (313 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	NKX2-2	NKX2-2 isoform 1. (273 aa)
	BMP2	Bone morphogenetic protein 2. (398 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (409 aa)
	BIN1	Bridging integrator 1. (597 aa)
	ID2	Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
	SPINT1	SPINT1 isoform 2. (529 aa)
	ENSPTRP00000084126	annotation not available (117 aa)
	MDK	Midkine (Neurite growth-promoting factor 2). (143 aa)
	ZNF365	Zinc finger protein 365. (407 aa)
	RHEB	RHEB isoform 1. (184 aa)
	CLCF1	Cardiotrophin-like cytokine factor 1 isoform X1. (225 aa)
	IL6ST	Interleukin 6 signal transducer (Gp130, oncostatin M receptor). (918 aa)
	PRPF19	PRP19/PSO4 pre-mRNA processing factor 19 homolog. (509 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	TENM4	Teneurin transmembrane protein 4. (2769 aa)
	ACY3	Aspartoacylase (Aminocyclase) 3. (319 aa)
	LOC748850	HDAC2 isoform 9. (445 aa)
	CK820_G0042963	RHEB isoform 3. (182 aa)
	OLIG2	OLIG2 isoform 1. (323 aa)
	ENSPTRP00000070165	annotation not available (67 aa)
	TTBK1	Tau tubulin kinase 1. (1321 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	PRMT5	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (620 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACY3	ASPA	ENSPTRP00000006835	ENSPTRP00000014620	Aspartoacylase (Aminocyclase) 3.	Aspartoacylase (Canavan disease).	0.626
ASPA	ACY3	ENSPTRP00000014620	ENSPTRP00000006835	Aspartoacylase (Canavan disease).	Aspartoacylase (Aminocyclase) 3.	0.626
BMP2	SHH	ENSPTRP00000022701	ENSPTRP00000075730	Bone morphogenetic protein 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.613
BMP2	TGFB1	ENSPTRP00000022701	ENSPTRP00000018930	Bone morphogenetic protein 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.548
CD22-2	EGR2	ENSPTRP00000048802	ENSPTRP00000004374	B-cell receptor CD22.	Early growth response 2.	0.809
CD22-2	ENSPTRP00000079007	ENSPTRP00000048802	ENSPTRP00000079007	B-cell receptor CD22.	annotation not available	0.435
CD22-2	OLIG2	ENSPTRP00000048802	ENSPTRP00000069533	B-cell receptor CD22.	OLIG2 isoform 1.	0.435
CK820_G0042963	MTOR	ENSPTRP00000069096	ENSPTRP00000000280	RHEB isoform 3.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.956
CLCF1	IL6ST	ENSPTRP00000089109	ENSPTRP00000065025	Cardiotrophin-like cytokine factor 1 isoform X1.	Interleukin 6 signal transducer (Gp130, oncostatin M receptor).	0.928
CLCF1	LIF	ENSPTRP00000089109	ENSPTRP00000024522	Cardiotrophin-like cytokine factor 1 isoform X1.	Leukemia inhibitory factor (Cholinergic differentiation factor).	0.539
DICER1	PRMT5	ENSPTRP00000046628	ENSPTRP00000063339	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.407
EGR2	CD22-2	ENSPTRP00000004374	ENSPTRP00000048802	Early growth response 2.	B-cell receptor CD22.	0.809
EGR2	ID2	ENSPTRP00000004374	ENSPTRP00000019998	Early growth response 2.	Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein.	0.489
ENSPTRP00000070165	MTOR	ENSPTRP00000070165	ENSPTRP00000000280	annotation not available	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.956
ENSPTRP00000079007	CD22-2	ENSPTRP00000079007	ENSPTRP00000048802	annotation not available	B-cell receptor CD22.	0.435
ENSPTRP00000079007	ENSPTRP00000084126	ENSPTRP00000079007	ENSPTRP00000084126	annotation not available	annotation not available	0.501
ENSPTRP00000079007	ID2	ENSPTRP00000079007	ENSPTRP00000019998	annotation not available	Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein.	0.501
ENSPTRP00000079007	NKX2-2	ENSPTRP00000079007	ENSPTRP00000022825	annotation not available	NKX2-2 isoform 1.	0.620
ENSPTRP00000079007	NKX6-2	ENSPTRP00000079007	ENSPTRP00000005418	annotation not available	NKX6-2 isoform 1.	0.479
ENSPTRP00000079007	SHH	ENSPTRP00000079007	ENSPTRP00000075730	annotation not available	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.404