49 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	ZMIZ1	Zinc finger, MIZ-type containing 1. (1073 aa)
	TSPAN14	Tetraspanin. (277 aa)
	YAP1	Yes-associated protein 1. (508 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (268 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] (1040 aa)
	LFNG-2	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (242 aa)
	AAK1	AP2 associated kinase 1. (963 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	POGLUT1	Protein O-glucosyltransferase 1. (392 aa)
	PDCD10	Programmed cell death 10. (212 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	GSX2	GSX2 isoform 2. (304 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	FKBP14	Peptidylprolyl isomerase. (211 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
	CCN3	NOV isoform 1. (357 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	BMP2K	BMP2 inducible kinase. (1162 aa)
	TM2D2	TM2 domain containing 2. (214 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	IL6ST	Interleukin 6 signal transducer (Gp130, oncostatin M receptor). (918 aa)
	RFNG	Beta-1,3-N-acetylglucosaminyltransferase. (333 aa)
	SLC35C2	Solute carrier family 35 member C2. (394 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
	EPN2	EPN2 isoform 5. (641 aa)
	NEPRO	Nucleolus and neural progenitor protein. (567 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
	MFNG	Beta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. (321 aa)
	CNTN6	CNTN6 isoform 1. (1028 aa)
	ROBO1	Roundabout guidance receptor 1. (1684 aa)
	ENHO	Energy homeostasis associated. (76 aa)
	GATA5	GATA binding protein 5. (397 aa)
	JAG2	Jagged canonical Notch ligand 2. (1130 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (232 aa)
	TM2D3	TM2 domain containing 3. (247 aa)
	HES5-2	Hes family bHLH transcription factor 5. (165 aa)
	LFNG	LFNG isoform 5. (405 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	ENSPTRP00000084287	annotation not available (136 aa)
	ENSPTRP00000086173	annotation not available (566 aa)
	TSPAN5	Tetraspanin. (268 aa)
	STAT3	Signal transducer and activator of transcription. (790 aa)
	ROBO2	Roundabout guidance receptor 2. (1439 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAK1	EPN2	ENSPTRP00000020635	ENSPTRP00000068433	AP2 associated kinase 1.	EPN2 isoform 5.	0.484
ASCL1	DLL1	ENSPTRP00000077846	ENSPTRP00000032142	Achaete-scute family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.677
ASCL1	GSX2	ENSPTRP00000077846	ENSPTRP00000027634	Achaete-scute family bHLH transcription factor 1.	GSX2 isoform 2.	0.594
ASCL1	HES1	ENSPTRP00000077846	ENSPTRP00000064171	Achaete-scute family bHLH transcription factor 1.	Hes family bHLH transcription factor 1.	0.522
ASCL1	HES5	ENSPTRP00000077846	ENSPTRP00000040760	Achaete-scute family bHLH transcription factor 1.	Hes family bHLH transcription factor 5.	0.490
ASCL1	HES5-2	ENSPTRP00000077846	ENSPTRP00000080637	Achaete-scute family bHLH transcription factor 1.	Hes family bHLH transcription factor 5.	0.490
CCN3	NOTCH1	ENSPTRP00000035113	ENSPTRP00000036924	NOV isoform 1.	NOTCH1 isoform 1.	0.608
CCN3	WNT1	ENSPTRP00000035113	ENSPTRP00000008364	NOV isoform 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.506
CNTN6	NOTCH1	ENSPTRP00000073805	ENSPTRP00000036924	CNTN6 isoform 1.	NOTCH1 isoform 1.	0.430
DLL1	ASCL1	ENSPTRP00000032142	ENSPTRP00000077846	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Achaete-scute family bHLH transcription factor 1.	0.677
DLL1	DLL4	ENSPTRP00000032142	ENSPTRP00000070341	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.552
DLL1	HES1	ENSPTRP00000032142	ENSPTRP00000064171	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 1.	0.499
DLL1	HES5	ENSPTRP00000032142	ENSPTRP00000040760	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.712
DLL1	HES5-2	ENSPTRP00000032142	ENSPTRP00000080637	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.712
DLL1	JAG1	ENSPTRP00000032142	ENSPTRP00000022729	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.712
DLL1	JAG2	ENSPTRP00000032142	ENSPTRP00000075993	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Jagged canonical Notch ligand 2.	0.484
DLL1	LFNG	ENSPTRP00000032142	ENSPTRP00000082555	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LFNG isoform 5.	0.636
DLL1	LFNG-2	ENSPTRP00000032142	ENSPTRP00000016656	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.	0.636
DLL1	MESP1	ENSPTRP00000032142	ENSPTRP00000012723	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mesoderm posterior bHLH transcription factor 1.	0.465
DLL1	MFNG	ENSPTRP00000032142	ENSPTRP00000071868	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1.	0.471