STRINGSTRING
MTOR MTOR PTAFR PTAFR PRKAA2 PRKAA2 SLC45A3 SLC45A3 SIRT1 SIRT1 PTH PTH P2RY6 P2RY6 DGAT2 DGAT2 NNMT NNMT GPD1 GPD1 FOXO1 FOXO1 HTR2A HTR2A IRS2 IRS2 HIF1A HIF1A PSEN1 PSEN1 PHKG2 PHKG2 KAT2A KAT2A RPTOR RPTOR STK11 STK11 GAPDHS GAPDHS PRKCE PRKCE LHCGR LHCGR SLC25A12 SLC25A12 IRS1 IRS1 CK820_G0037244 CK820_G0037244 PDGFB PDGFB PPARA PPARA KAT2B KAT2B PTH1R PTH1R P2RY1 P2RY1 PPARGC1A PPARGC1A NFKB1 NFKB1 EGF EGF GPLD1 GPLD1 MAS1 MAS1 MLXIPL MLXIPL RGN RGN GPT GPT AVPR1B AVPR1B GCK GCK ZBTB20 ZBTB20 ARNT ARNT CD244 CD244 PRKAA1 PRKAA1 GCG GCG PRXL2C PRXL2C P2RX7 P2RX7 CK820_G0015936 CK820_G0015936 PPP1R3E PPP1R3E PPP1R3G PPP1R3G HAS2 HAS2 EPM2AIP1 EPM2AIP1 ENSPTRP00000062913 ENSPTRP00000062913 INSR INSR SLC4A4 SLC4A4 ENSPTRP00000064845 ENSPTRP00000064845 MLXIPL-2 MLXIPL-2 DYRK2 DYRK2 ENSPTRP00000066334 ENSPTRP00000066334 ARPP19 ARPP19 IGF1 IGF1 MLST8 MLST8 WDR5 WDR5 PTPN2 PTPN2 RGN-2 RGN-2 ADCYAP1R1 ADCYAP1R1 SRC SRC ADCYAP1R1-2 ADCYAP1R1-2 IGF2 IGF2 PPP4R3B PPP4R3B DDB1 DDB1 AKT1 AKT1 ACTN3 ACTN3 SORBS1 SORBS1 ENSPTRP00000089297 ENSPTRP00000089297 AKT2 AKT2 SNCA SNCA SIRT1-2 SIRT1-2 APP APP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
SLC45A3Solute carrier family 45, member 3. (553 aa)
SIRT1SIRT1 isoform 2. (751 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
FOXO1FOXO1 isoform 1. (655 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
IRS2IRS2 isoform 1. (1340 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
PHKG2Phosphorylase kinase, gamma 2 (Testis); Belongs to the protein kinase superfamily. (532 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
RPTORRegulatory associated protein of MTOR, complex 1. (1324 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
GAPDHSGlyceraldehyde-3-phosphate dehydrogenase. (408 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (699 aa)
SLC25A12Solute carrier family 25 (Mitochondrial carrier, Aralar), member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (678 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
CK820_G0037244NTSR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GPLD1GPLD1 isoform 2. (840 aa)
MAS1MAS1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (325 aa)
MLXIPLMLX interacting protein like. (852 aa)
RGNRegucalcin (Senescence marker protein-30). (299 aa)
GPTGlutamic--pyruvic transaminase. (496 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
GCKPhosphotransferase. (466 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
CD244CD244 isoform 1. (365 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
GCGGCG isoform 1. (180 aa)
PRXL2CAAED1 isoform 2. (226 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
CK820_G0015936C12orf76 isoform 1. (107 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (358 aa)
HAS2Hyaluronan synthase 2. (554 aa)
EPM2AIP1EPM2A (Laforin) interacting protein 1. (607 aa)
ENSPTRP00000062913annotation not available (169 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
SLC4A4Anion exchange protein. (1100 aa)
ENSPTRP00000064845annotation not available (112 aa)
MLXIPL-2MLX interacting protein like. (852 aa)
DYRK2Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2. (601 aa)
ENSPTRP00000066334annotation not available (316 aa)
ARPP19cAMP regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (131 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
MLST8MLST8 isoform 3. (327 aa)
WDR5WD repeat domain 5. (334 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (421 aa)
RGN-2Regucalcin. (299 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa)
SRCTyrosine-protein kinase. (542 aa)
ADCYAP1R1-2ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (517 aa)
IGF2Insulin like growth factor 2. (236 aa)
PPP4R3BSMEK homolog 2, suppressor of mek1 (Dictyostelium). (849 aa)
DDB1Damage-specific DNA binding protein 1, 127kDa. (1147 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (944 aa)
SORBS1Sorbin and SH3 domain containing 1. (1294 aa)
ENSPTRP00000089297annotation not available (265 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
SIRT1-2Sirtuin 1. (751 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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