STRINGSTRING
PLCB1 PLCB1 JAG1 JAG1 KAT14 KAT14 TGIF2 TGIF2 PAFAH1B1 PAFAH1B1 MCRS1 MCRS1 ENSPTRP00000077428 ENSPTRP00000077428 ZZZ3 ZZZ3 NOCT NOCT ENSPTRP00000074020 ENSPTRP00000074020 SCX SCX RPS6KA6 RPS6KA6 TDG TDG ACTL6A ACTL6A WDR5 WDR5 CLASP1 CLASP1 ENSPTRP00000066334 ENSPTRP00000066334 BAG6 BAG6 ENSPTRP00000066220 ENSPTRP00000066220 ENSPTRP00000065728 ENSPTRP00000065728 RUVBL2 RUVBL2 CLASP2 CLASP2 NFE2L2 NFE2L2 HES1 HES1 B4GALT5 B4GALT5 TADA3 TADA3 KAT2B KAT2B DAG1 DAG1 ACTR8 ACTR8 HESX1 HESX1 POGLUT1 POGLUT1 DHX36 DHX36 YEATS2 YEATS2 SFRP2 SFRP2 TBX18 TBX18 LAMA2 LAMA2 DLL1 DLL1 SEPTIN7 SEPTIN7 WNT2 WNT2 SOX17 SOX17 RAB14 RAB14 NOTCH1 NOTCH1 AMOT AMOT CRB2 CRB2 PHLDB1 PHLDB1 WDPCP WDPCP CTNNB1 CTNNB1 UTP25 UTP25 INO80 INO80 NIPBL NIPBL CK820_G0053530 CK820_G0053530 NIBAN2 NIBAN2 KHDC3L KHDC3L CDK1 CDK1 WNT3A WNT3A RUVBL1 RUVBL1 WNT2B WNT2B LHX1 LHX1 PHLDB2 PHLDB2 INO80D INO80D INSR INSR WNT4 WNT4 DR1 DR1 CCSAP CCSAP NODAL NODAL TENM4 TENM4 NFRKB NFRKB WNT1 WNT1 RACGAP1 RACGAP1 RBM19 RBM19 MBIP MBIP OTX2 OTX2 YY1 YY1 SGF29 SGF29 TADA2A TADA2A KAT2A KAT2A LAMA3 LAMA3 TLE6 TLE6 PHLDB3 PHLDB3 TFPT TFPT OSR1 OSR1 INO80B INO80B LAMA4 LAMA4 ENSPTRP00000091771 ENSPTRP00000091771 LOC100614490 LOC100614490 TRIP12 TRIP12 ZBED3 ZBED3 FOXA2 FOXA2 TFPT-2 TFPT-2 LAMA5 LAMA5 HNF4A HNF4A CFL1 CFL1 NR2C2 NR2C2 LAMA1 LAMA1 UCHL5 UCHL5 INO80E INO80E RACK1 RACK1 NLRP5 NLRP5 ENSPTRP00000079145 ENSPTRP00000079145
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
KAT14Lysine acetyltransferase 14. (782 aa)
TGIF2Homeobox protein TGIF2. (237 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
MCRS1Microspherule protein 1. (475 aa)
ENSPTRP00000077428annotation not available (202 aa)
ZZZ3Zinc finger, ZZ-type containing 3. (903 aa)
NOCTCCR4 carbon catabolite repression 4-like. (431 aa)
ENSPTRP00000074020annotation not available (228 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
TDGThymine-DNA glycosylase. (410 aa)
ACTL6AACTL6A isoform 2; Belongs to the actin family. (430 aa)
WDR5WD repeat domain 5. (334 aa)
CLASP1Cytoplasmic linker associated protein 1. (1549 aa)
ENSPTRP00000066334annotation not available (316 aa)
BAG6BAG6 isoform 3. (1162 aa)
ENSPTRP00000066220annotation not available (211 aa)
ENSPTRP00000065728annotation not available (516 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
CLASP2CLASP2 isoform 3. (1522 aa)
NFE2L2Nuclear factor (Erythroid-derived 2)-like 2. (605 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
B4GALT5UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5. (388 aa)
TADA3Transcriptional adaptor 3. (432 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
DAG1Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
HESX1Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). (185 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
DHX36DEAH-box helicase 36. (1008 aa)
YEATS2YEATS domain containing 2. (1416 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
TBX18T-box transcription factor 18. (607 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
SEPTIN7Septin-7; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-li [...] (447 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
SOX17SOX17 isoform 1. (416 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
AMOTAMOT isoform 2. (1094 aa)
CRB2CRB2 isoform 1. (1285 aa)
PHLDB1Pleckstrin homology like domain family B member 1. (1377 aa)
WDPCPWDPCP isoform 2. (746 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
UTP25Digestive organ expansion factor homolog (Zebrafish). (756 aa)
INO80INO80 complex ATPase subunit. (1556 aa)
NIPBLNipped-B protein. (2804 aa)
CK820_G0053530EHMT1 isoform 4. (1100 aa)
NIBAN2FAM129B isoform 2. (746 aa)
KHDC3LChromosome 6 open reading frame 221. (217 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
PHLDB2Pleckstrin homology-like domain family B member 2 isoform X4. (1253 aa)
INO80DINO80 complex subunit D. (1027 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
DR1Down-regulator of transcription 1, TBP-binding (Negative cofactor 2). (176 aa)
CCSAPCentriole, cilia and spindle associated protein. (275 aa)
NODALNODAL isoform 2. (347 aa)
TENM4Teneurin transmembrane protein 4. (2769 aa)
NFRKBNuclear factor related to kappaB binding protein. (1299 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
RACGAP1Rac GTPase activating protein 1. (632 aa)
RBM19RNA binding motif protein 19. (961 aa)
MBIPMAP3K12 binding inhibitory protein 1. (344 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
YY1YY1 transcription factor. (414 aa)
SGF29SGF29 isoform 6. (265 aa)
TADA2ATranscriptional adapter. (443 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
TLE6TLE family member 6, subcortical maternal complex member. (572 aa)
PHLDB3PHLDB3 isoform 1. (641 aa)
TFPTTCF3 (E2A) fusion partner (In childhood Leukemia). (253 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
INO80BINO80 complex subunit B isoform X1. (356 aa)
LAMA4LAMA4 isoform 3. (1823 aa)
ENSPTRP00000091771annotation not available (149 aa)
LOC100614490G/T mismatch-specific thymine DNA glycosylase pseudogene. (405 aa)
TRIP12Thyroid hormone receptor interactor 12. (2068 aa)
ZBED3Zinc finger BED-type containing 3. (234 aa)
FOXA2FOXA2 isoform 1. (464 aa)
TFPT-2TCF3 fusion partner. (253 aa)
LAMA5Laminin, alpha 5. (2203 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
CFL1CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. (204 aa)
NR2C2NR2C2 isoform 1. (619 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (393 aa)
INO80EINO80E isoform 1. (244 aa)
RACK1Receptor for activated C kinase 1. (321 aa)
NLRP5NLRP5 isoform 3. (1180 aa)
ENSPTRP00000079145annotation not available (395 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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