STRINGSTRING
ACVRL1 ACVRL1 MEN1 MEN1 CREB3L1 CREB3L1 ANKRD1 ANKRD1 BMPR1A BMPR1A PARP1 PARP1 ZMIZ1 ZMIZ1 TRIM33 TRIM33 SKI SKI ACVR1 ACVR1 GATA4 GATA4 ENSPTRP00000076011 ENSPTRP00000076011 PPARG PPARG DROSHA DROSHA FOS FOS TGFB1I1 TGFB1I1 SMAD5 SMAD5 FERMT2 FERMT2 CITED2 CITED2 ENSPTRP00000081714 ENSPTRP00000081714 LDLRAD4 LDLRAD4 RANBP3 RANBP3 CK820_G0045089 CK820_G0045089 LOC100614141 LOC100614141 RANBP3L RANBP3L ENSPTRP00000086097 ENSPTRP00000086097 SMURF2 SMURF2 SMAD3 SMAD3 INTS8 INTS8 TGFBR3 TGFBR3 PAX6 PAX6 SNW1 SNW1 ENSPTRP00000064416 ENSPTRP00000064416 ENSPTRP00000063212 ENSPTRP00000063212 SMAD2 SMAD2 PURB PURB EID2 EID2 SMAD9 SMAD9 FOXH1-2 FOXH1-2 HMGA2 HMGA2 COL5A2 COL5A2 IPO7 IPO7 SMURF1 SMURF1 CTNNB1 CTNNB1 USP9X USP9X SKOR2 SKOR2 PMEPA1 PMEPA1 SKIL SKIL MEF2A MEF2A DAB2 DAB2 TGFBRAP1 TGFBRAP1 TGFBR1 TGFBR1 USP15 USP15 TGFBR2 TGFBR2 ENSPTRP00000075374 ENSPTRP00000075374 AXIN1 AXIN1 USP9Y USP9Y CITED1 CITED1 FOXH1 FOXH1 ZC3H3 ZC3H3 HIPK2 HIPK2 COL1A2 COL1A2 MAGI2 MAGI2 SMAD1 SMAD1 BMPR1B BMPR1B BMP2 BMP2 COL3A1 COL3A1 ZBTB7A ZBTB7A SMAD4 SMAD4 SMAD7 SMAD7 AXIN2 AXIN2 DDX5 DDX5 MYOCD MYOCD STUB1 STUB1 PML PML SKOR1 SKOR1 SMAD6 SMAD6 RNF111 RNF111 TCF12 TCF12 YY1 YY1 PPM1A PPM1A SAV1 SAV1 RGCC RGCC ACVR1B ACVR1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
MEN1MEN1 isoform 14. (615 aa)
CREB3L1cAMP responsive element binding protein 3-like 1. (519 aa)
ANKRD1Ankyrin repeat domain 1 (Cardiac muscle). (319 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
ZMIZ1Zinc finger, MIZ-type containing 1. (1073 aa)
TRIM33Tripartite motif containing 33. (1127 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
GATA4GATA binding protein 4. (443 aa)
ENSPTRP00000076011annotation not available (70 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
DROSHADrosha, ribonuclease type III. (1380 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (470 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
FERMT2Fermitin family member 2. (706 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
ENSPTRP00000081714annotation not available (310 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
RANBP3RAN binding protein 3. (562 aa)
CK820_G0045089RANBP3 isoform 23. (97 aa)
LOC100614141Importin-7 pseudogene. (373 aa)
RANBP3LRAN binding protein 3 like. (490 aa)
ENSPTRP00000086097annotation not available (312 aa)
SMURF2E3 ubiquitin-protein ligase. (744 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
INTS8Integrator complex subunit 8. (995 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
PAX6PAX6 isoform 13. (436 aa)
SNW1SNW domain containing 1. (571 aa)
ENSPTRP00000064416annotation not available (502 aa)
ENSPTRP00000063212annotation not available (75 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PURBPurine-rich element-binding protein B. (312 aa)
EID2EP300 interacting inhibitor of differentiation 2. (236 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
FOXH1-2Forkhead box H1. (365 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
IPO7IPO7 isoform 1. (1038 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
USP9XUbiquitin specific peptidase 9, X-linked; Belongs to the peptidase C19 family. (2591 aa)
SKOR2SKI family transcriptional corepressor 2. (1012 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (287 aa)
SKILSKI like proto-oncogene. (684 aa)
MEF2AMyocyte enhancer factor 2A. (507 aa)
DAB2Disabled homolog 2, mitogen-responsive phosphoprotein. (770 aa)
TGFBRAP1Transforming growth factor, beta receptor associated protein 1. (860 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ENSPTRP00000075374annotation not available (236 aa)
AXIN1AXIN1 isoform 2. (859 aa)
USP9YUSP9Y isoform 1; Belongs to the peptidase C19 family. (2523 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
FOXH1FOXH1 isoform 1. (365 aa)
ZC3H3Zinc finger CCCH-type containing 3. (952 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1283 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (584 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
AXIN2AXIN2 isoform 1. (843 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa)
MYOCDMYOCD isoform 2. (986 aa)
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase. (303 aa)
PMLPML isoform 6. (836 aa)
SKOR1SKI family transcriptional corepressor 1. (962 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
RNF111RNF111 isoform 5. (1003 aa)
TCF12Transcription factor 12. (706 aa)
YY1YY1 transcription factor. (414 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
RGCCChromosome 13 open reading frame 15. (137 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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