STRINGSTRING
IL6-2 IL6-2 HES5-2 HES5-2 JAK2 JAK2 IL5 IL5 IL10RA IL10RA CCL5 CCL5 ADIPOR1 ADIPOR1 IL10 IL10 F2 F2 IL23A IL23A IL26 IL26 CENPJ CENPJ PIBF1 PIBF1 CRLF3 CRLF3 GH1 GH1 IFNL1 IFNL1 CYP1B1 CYP1B1 IL12A IL12A KIT KIT PRLR PRLR F2R F2R ENSPTRP00000029460 ENSPTRP00000029460 IL4 IL4 IL12B IL12B PRL PRL PTK2B PTK2B NOTCH1 NOTCH1 HES5 HES5 IL10RB IL10RB IL12RB1 IL12RB1 TYK2 TYK2 OCIAD2 OCIAD2 GH1-2 GH1-2 ENSPTRP00000061612 ENSPTRP00000061612 ENSPTRP00000061970 ENSPTRP00000061970 ERBB4 ERBB4 HES1 HES1 CK820_G0011608 CK820_G0011608 IL6 IL6 IL23R IL23R IL4-2 IL4-2 LEP LEP GHR GHR ENSPTRP00000075254 ENSPTRP00000075254 IL7R IL7R AGAP2 AGAP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6-2Interleukin 6. (234 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
CCL5C-C motif chemokine. (91 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
IL26IL26 isoform 1. (171 aa)
CENPJCentromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born [...] (1338 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (757 aa)
CRLF3Cytokine receptor-like factor 3. (442 aa)
GH1Growth hormone variant; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. (271 aa)
IFNL1Interferon lambda 1. (200 aa)
CYP1B1Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
F2RCoagulation factor II (Thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
ENSPTRP00000029460Interleukin 5. (134 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
PRLPRL isoform 1. (227 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
IL10RBInterleukin 10 receptor, beta. (325 aa)
IL12RB1IL12RB1 isoform 1. (662 aa)
TYK2Tyrosine-protein kinase. (1184 aa)
OCIAD2OCIA domain containing 2. (154 aa)
GH1-2Chorionic somatomammotropin A2. (222 aa)
ENSPTRP00000061612annotation not available (208 aa)
ENSPTRP00000061970annotation not available (325 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
CK820_G0011608CSH2 isoform 1. (199 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
IL23RIL23R isoform 1. (629 aa)
IL4-2Interleukin 4. (153 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
GHRGrowth hormone receptor. (645 aa)
ENSPTRP00000075254annotation not available (159 aa)
IL7RInterleukin 7 receptor. (459 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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