STRINGSTRING
ABL1 ABL1 ENSPTRP00000092837 ENSPTRP00000092837 STAT3 STAT3 ENSPTRP00000090382 ENSPTRP00000090382 BCL2 BCL2 LOC473484 LOC473484 BRAF-2 BRAF-2 ENSPTRP00000088742 ENSPTRP00000088742 ENSPTRP00000088670 ENSPTRP00000088670 RELB RELB RORA RORA ENTPD7 ENTPD7 RORC RORC ENSPTRP00000080295 ENSPTRP00000080295 IL6-2 IL6-2 LEF1 LEF1 BRAF BRAF ENSPTRP00000077720 ENSPTRP00000077720 SHH SHH ENSPTRP00000075447 ENSPTRP00000075447 FOXP1 FOXP1 SYK SYK NKX2-3 NKX2-3 ENSPTRP00000074467 ENSPTRP00000074467 ADA ADA IL4-2 IL4-2 ENSPTRP00000069560 ENSPTRP00000069560 SEMA4A SEMA4A FUT7 FUT7 IL6 IL6 BCL6 BCL6 SPN-2 SPN-2 GATA3 GATA3 ATP7A ATP7A ATF2 ATF2 CK820_G0012168 CK820_G0012168 SPN SPN ARMC5 ARMC5 BCL11B BCL11B SLAMF6 SLAMF6 ANXA1 ANXA1 BCL3 BCL3 IL2RG IL2RG GPR18 GPR18 SASH3 SASH3 FOXP3 FOXP3 RC3H2 RC3H2 TNFSF8 TNFSF8 CTSL CTSL TOX TOX GLI3 GLI3 CD83 CD83 IRF4 IRF4 PRR7 PRR7 IL12B IL12B ITK ITK IL4 IL4 IRF1 IRF1 PTGER4 PTGER4 IL21 IL21 RHOA RHOA EOMES EOMES PAX1 PAX1 IL18R1 IL18R1 ZAP70 ZAP70 RSAD2 RSAD2 TBX21 TBX21 TMEM98 TMEM98 ZFPM1 ZFPM1 IL4R IL4R BATF BATF GPR183 GPR183 STAT6 STAT6 CRACR2A CRACR2A HLX HLX RC3H1 RC3H1 LY9 LY9 ZBTB7B ZBTB7B IL6R IL6R PLA2G2D PLA2G2D MTOR MTOR RPL22 RPL22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABL1Tyrosine-protein kinase. (1149 aa)
ENSPTRP00000092837annotation not available (325 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
ENSPTRP00000090382annotation not available (493 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LOC473484Cathepsin L1. (276 aa)
BRAF-2BRAF isoform 2. (766 aa)
ENSPTRP00000088742annotation not available (116 aa)
ENSPTRP00000088670annotation not available (116 aa)
RELBRELB isoform 3. (567 aa)
RORARAR-related orphan receptor A. (555 aa)
ENTPD7Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (605 aa)
RORCRAR related orphan receptor C. (525 aa)
ENSPTRP00000080295annotation not available (95 aa)
IL6-2Interleukin 6. (234 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
ENSPTRP00000077720annotation not available (54 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ENSPTRP00000075447annotation not available (88 aa)
FOXP1FOXP1 isoform 2. (693 aa)
SYKTyrosine-protein kinase. (635 aa)
NKX2-3NKX2-3 isoform 1. (366 aa)
ENSPTRP00000074467annotation not available (129 aa)
ADAAdenosine deaminase. (412 aa)
IL4-2Interleukin 4. (153 aa)
ENSPTRP00000069560annotation not available (214 aa)
SEMA4ASEMA4A isoform 10; Belongs to the semaphorin family. (761 aa)
FUT7Fucosyltransferase 7. (342 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
BCL6BCL6 transcription repressor. (706 aa)
SPN-2SPN isoform 1. (418 aa)
GATA3GATA binding protein 3. (444 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
SPNSPN isoform 3. (400 aa)
ARMC5Armadillo repeat containing 5. (1030 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
SLAMF6SLAM family member 6. (332 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
BCL3BCL3 transcription coactivator. (454 aa)
IL2RGIL2RG isoform 1. (369 aa)
GPR18Probable G-protein coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (331 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
FOXP3FOXP3 isoform 4. (456 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
TNFSF8Tumor necrosis factor ligand 3A; Belongs to the tumor necrosis factor family. (234 aa)
CTSLCTSL isoform 2; Belongs to the peptidase C1 family. (333 aa)
TOXThymocyte selection-associated high mobility group box. (526 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
CD83CD83 isoform 2. (205 aa)
IRF4Interferon regulatory factor 4. (451 aa)
PRR7Proline rich 7 (Synaptic). (274 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
ITKTyrosine-protein kinase. (620 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa)
IRF1Interferon regulatory factor. (325 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (By similarity). Belongs to the G-protein coupled receptor 1 family. (490 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
RHOARas homolog family member A. (193 aa)
EOMESEOMES isoform 2. (704 aa)
PAX1PAX1 isoform 1. (457 aa)
IL18R1Uncharacterized protein. (440 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
RSAD2RSAD2 isoform 1. (361 aa)
TBX21T-box transcription factor 21. (535 aa)
TMEM98Transmembrane protein 98. (226 aa)
ZFPM1ZFPM1 isoform 1. (974 aa)
IL4RIL4R isoform 2. (827 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (361 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
CRACR2ACRACR2A isoform 3. (732 aa)
HLXH2.0-like homeobox. (493 aa)
RC3H1Ring finger and CCCH-type domains 1. (1134 aa)
LY9LY9 isoform 4. (655 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
IL6RInterleukin 6 receptor. (442 aa)
PLA2G2DPhospholipase A(2). (161 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
RPL22Ribosomal protein L22. (128 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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