STRINGSTRING
ENSPTRP00000071088 ENSPTRP00000071088 IL23R IL23R RIPK2 RIPK2 ENSPTRP00000068326 ENSPTRP00000068326 SOCS5 SOCS5 CBFB CBFB RARA RARA SHB SHB ANXA1 ANXA1 GIMAP1 GIMAP1 IL2RG IL2RG NKAP NKAP IL12RB1 IL12RB1 SASH3 SASH3 FOXP3 FOXP3 CCL19 CCL19 GLI3 GLI3 MYB MYB PATR-DRA PATR-DRA CD83 CD83 IL12B IL12B AP3B1 AP3B1 CD86 CD86 CD80 CD80 NFKBIZ NFKBIZ RHOA RHOA IHH IHH ZAP70 ZAP70 NFKBID NFKBID IL4R IL4R MALT1 MALT1 RUNX3 RUNX3 ZBTB7B ZBTB7B TNFSF4 TNFSF4 HLX HLX ITPKB ITPKB NLRP3 NLRP3 IL18 IL18 ZBTB16 ZBTB16 NCKAP1L NCKAP1L IL23A IL23A AP3D1 AP3D1 IFNG IFNG PNP PNP SOCS1 SOCS1 LILRB4 LILRB4 ENSPTRP00000073371 ENSPTRP00000073371 ADA ADA SYK SYK TGFBR2 TGFBR2 SHH SHH CK820_G0040570 CK820_G0040570 LGALS9 LGALS9 CK820_G0040570-2 CK820_G0040570-2 RUNX1 RUNX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPTRP00000071088annotation not available (500 aa)
IL23RIL23R isoform 1. (629 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
ENSPTRP00000068326annotation not available (488 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
CBFBCore-binding factor, beta subunit. (182 aa)
RARARARA isoform 4. (624 aa)
SHBSrc homology 2 domain containing adaptor protein B. (509 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
GIMAP1GTPase IMAP family member 5. (500 aa)
IL2RGIL2RG isoform 1. (369 aa)
NKAPNFKB activating protein. (415 aa)
IL12RB1IL12RB1 isoform 1. (662 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
FOXP3FOXP3 isoform 4. (456 aa)
CCL19C-C motif chemokine. (98 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
MYBMYB proto-oncogene, transcription factor. (761 aa)
PATR-DRAMHC class II protein; Belongs to the MHC class II family. (254 aa)
CD83CD83 isoform 2. (205 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1045 aa)
CD86CD86 isoform 3. (329 aa)
CD80CD80 isoform 1. (288 aa)
NFKBIZNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta. (718 aa)
RHOARas homolog family member A. (193 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
NFKBIDNFKB inhibitor delta. (465 aa)
IL4RIL4R isoform 2. (827 aa)
MALT1Mucosa associated lymphoid tissue lymphoma translocation gene 1. (824 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa)
HLXH2.0-like homeobox. (493 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (946 aa)
NLRP3NLRP3 isoform 2. (1025 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
AP3D1AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1215 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
LILRB4LILRB4 isoform 7. (449 aa)
ENSPTRP00000073371annotation not available (431 aa)
ADAAdenosine deaminase. (412 aa)
SYKTyrosine-protein kinase. (635 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
CK820_G0040570PRKCZ isoform 2. (457 aa)
LGALS9Galectin. (355 aa)
CK820_G0040570-2PRKCZ isoform 4. (95 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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