28 items (Pan troglodytes) - STRING interaction network

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Your Input:
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
	JAK3	Tyrosine-protein kinase. (1124 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	CBFB	Core-binding factor, beta subunit. (182 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
	TNFSF18	Tumor necrosis factor ligand 2A. (199 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	LOXL3	Lysyl oxidase-like 3. (753 aa)
	ENSPTRP00000073371	annotation not available (431 aa)
	IL4-2	Interleukin 4. (153 aa)
	LOC468520	Zinc finger protein 271. (672 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (599 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	FOXP3	FOXP3 isoform 4. (456 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1191 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa)
	RUNX3	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
	ZBTB7B	Zinc finger and BTB domain containing 7B. (573 aa)
	TNFSF4	Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1134 aa)
	HLX	H2.0-like homeobox. (493 aa)
	SOCS1	Suppressor of cytokine signaling 1. (211 aa)
	IL4R	IL4R isoform 2. (827 aa)
	TBX21	T-box transcription factor 21. (535 aa)
	SMAD7	Mothers against decapentaplegic homolog. (491 aa)
	ANXA1	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	FOXP3	ENSPTRP00000068244	ENSPTRP00000037587	BCL6 transcription repressor.	FOXP3 isoform 4.	0.617
BCL6	IL2	ENSPTRP00000068244	ENSPTRP00000028193	BCL6 transcription repressor.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.531
BCL6	IL4	ENSPTRP00000068244	ENSPTRP00000029464	BCL6 transcription repressor.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.	0.563
BCL6	IL4-2	ENSPTRP00000068244	ENSPTRP00000071542	BCL6 transcription repressor.	Interleukin 4.	0.563
BCL6	TBX21	ENSPTRP00000068244	ENSPTRP00000015869	BCL6 transcription repressor.	T-box transcription factor 21.	0.748
CBFB	FOXP3	ENSPTRP00000060319	ENSPTRP00000037587	Core-binding factor, beta subunit.	FOXP3 isoform 4.	0.804
CBFB	IHH	ENSPTRP00000060319	ENSPTRP00000022106	Core-binding factor, beta subunit.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.639
CBFB	RUNX1	ENSPTRP00000060319	ENSPTRP00000092866	Core-binding factor, beta subunit.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.999
CBFB	RUNX3	ENSPTRP00000060319	ENSPTRP00000000614	Core-binding factor, beta subunit.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.996
ENSPTRP00000073371	IL4	ENSPTRP00000073371	ENSPTRP00000029464	annotation not available	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.	0.408
ENSPTRP00000073371	IL4-2	ENSPTRP00000073371	ENSPTRP00000071542	annotation not available	Interleukin 4.	0.408
ENSPTRP00000073371	IL4R	ENSPTRP00000073371	ENSPTRP00000013524	annotation not available	IL4R isoform 2.	0.678
ENSPTRP00000073371	JAK3	ENSPTRP00000073371	ENSPTRP00000040293	annotation not available	Tyrosine-protein kinase.	0.506
ENSPTRP00000073371	SOCS1	ENSPTRP00000073371	ENSPTRP00000013256	annotation not available	Suppressor of cytokine signaling 1.	0.704
ENSPTRP00000073371	SOCS5	ENSPTRP00000073371	ENSPTRP00000061344	annotation not available	Suppressor of cytokine signaling 5.	0.545
FOXP3	BCL6	ENSPTRP00000037587	ENSPTRP00000068244	FOXP3 isoform 4.	BCL6 transcription repressor.	0.617
FOXP3	CBFB	ENSPTRP00000037587	ENSPTRP00000060319	FOXP3 isoform 4.	Core-binding factor, beta subunit.	0.804
FOXP3	IL2	ENSPTRP00000037587	ENSPTRP00000028193	FOXP3 isoform 4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.944
FOXP3	IL4	ENSPTRP00000037587	ENSPTRP00000029464	FOXP3 isoform 4.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.	0.754
FOXP3	IL4-2	ENSPTRP00000037587	ENSPTRP00000071542	FOXP3 isoform 4.	Interleukin 4.	0.754