STRINGSTRING
MAPKAPK2 MAPKAPK2 MAPKAPK3 MAPKAPK3 PAK2 PAK2 KDR KDR VEGFC VEGFC MAPK14 MAPK14 HSPB1 HSPB1 PTK2B PTK2B VEGFD VEGFD CLEC14A CLEC14A FLT4 FLT4 VEGFB VEGFB FOXC2 FOXC2 DAB2IP DAB2IP PGF PGF FOXC1 FOXC1 XBP1 XBP1 SULF1 SULF1 ENSPTRP00000075918 ENSPTRP00000075918 ENSPTRP00000076371 ENSPTRP00000076371 SRC SRC FYN FYN BCAR1 BCAR1 FGF10 FGF10 PTK2 PTK2 VAV2 VAV2 FGF18 FGF18 PRKD2 PRKD2 VAV1 VAV1 PRKD1 PRKD1 FLT1 FLT1 FGF9 FGF9 NRP1 NRP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPKAPK2Mitogen-activated protein kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MAPKAPK3Mitogen-activated protein kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
PAK2Non-specific serine/threonine protein kinase. (476 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
CLEC14AC-type lectin domain containing 14A. (490 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
FOXC1FOXC1 isoform 1. (550 aa)
XBP1XBP1 isoform 4. (381 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (901 aa)
ENSPTRP00000075918annotation not available (365 aa)
ENSPTRP00000076371annotation not available (194 aa)
SRCTyrosine-protein kinase. (542 aa)
FYNTyrosine-protein kinase. (537 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (873 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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