STRINGSTRING
MIF MIF DHX9 DHX9 ZMIZ1 ZMIZ1 HRAS HRAS WNT1 WNT1 PLA2G1B PLA2G1B PML PML CTC1 CTC1 CDC6 CDC6 NGFR NGFR SIRT6 SIRT6 TGFB1 TGFB1 E2F1 E2F1 LIF LIF PDGFB PDGFB BRK1 BRK1 EREG EREG CCNA2 CCNA2 NDUFS4 NDUFS4 CCNB1 CCNB1 ESR1 ESR1 AQP1 AQP1 CDK6 CDK6 WNT2 WNT2 CDK4 CDK4 FBRS FBRS FN1 FN1 LIG4 LIG4 CD74 CD74 WAPL WAPL SPHK1 SPHK1 CDKN1A CDKN1A DDR2 DDR2 CD248 CD248 CK820_G0012168 CK820_G0012168 FBLN1 FBLN1 IGF1 IGF1 ITGB3 ITGB3 LOC452606 LOC452606 EGFR EGFR ABL1 ABL1 MYC MYC PDGFD PDGFD PDGFRB PDGFRB FGF10 FGF10 XRCC4 XRCC4 S100A6 S100A6 FNDC3B FNDC3B RNASEH2B RNASEH2B FOSL2 FOSL2 WNT5A WNT5A LOC100614824 LOC100614824 PDGFC PDGFC E2F1-2 E2F1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MIFMacrophage migration inhibitory factor. (115 aa)
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 9. (1270 aa)
ZMIZ1Zinc finger, MIZ-type containing 1. (1073 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PLA2G1BPhospholipase A(2). (148 aa)
PMLPML isoform 6. (836 aa)
CTC1CTS telomere maintenance complex component 1. (1159 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
NGFRNerve growth factor receptor. (427 aa)
SIRT6SIRT6 isoform 1. (355 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
E2F1E2F transcription factor 1. (437 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
EREGEREG isoform 1. (169 aa)
CCNA2CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
NDUFS4NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (175 aa)
CCNB1CCNB1 isoform 1; Belongs to the cyclin family. (433 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
AQP1Aquaporin-1 isoform X2. (269 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
FBRSFBRS isoform 1. (979 aa)
FN1FN1 isoform 1. (2477 aa)
LIG4DNA ligase. (911 aa)
CD74CD74 isoform 5. (296 aa)
WAPLWAPL cohesin release factor. (1190 aa)
SPHK1Sphingosine kinase 1. (470 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
CD248CD248 molecule, endosialin. (757 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (721 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
LOC452606ATP-dependent RNA helicase A pseudogene. (350 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 4. (334 aa)
S100A6Protein S100; Belongs to the S-100 family. (90 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
RNASEH2BRibonuclease H2, subunit B. (315 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LOC100614824Uncharacterized LOC100614824. (54 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
E2F1-2E2F transcription factor 1. (437 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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