101 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TDRD1	Tudor domain containing 1. (1189 aa)
	BRCA2	Breast cancer 2, early onset. (3418 aa)
	SOHLH2	CCDC169-SOHLH2 isoform 1. (424 aa)
	PDE3A	Phosphodiesterase. (1141 aa)
	METTL3	N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (580 aa)
	C14H14orf39	C14orf39 isoform 1. (587 aa)
	MARF1	Meiosis regulator and mRNA stability factor 1. (1742 aa)
	YBX2	Y-box binding protein 2. (365 aa)
	ZNF830	Zinc finger protein 830. (388 aa)
	AMH	Anti-Mullerian hormone. (560 aa)
	NANOS3	NANOS3 isoform 4; Belongs to the nanos family. (192 aa)
	NANOS2	Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
	CCDC155	Coiled-coil domain containing 155. (562 aa)
	AURKC	AURKC isoform 1; Belongs to the protein kinase superfamily. (309 aa)
	FIGLA	Folliculogenesis specific bHLH transcription factor. (219 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	NANOS1	Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (290 aa)
	PABPC1L	Poly(A) binding protein cytoplasmic 1 like. (330 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (396 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
	MLH1	MutL homolog 1, colon cancer, nonpolyposis type 2. (756 aa)
	GPR149	G protein-coupled receptor 149. (731 aa)
	PTX3	Pentraxin 3, long. (381 aa)
	EREG	EREG isoform 1. (169 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (409 aa)
	YTHDC2	YTH domain containing 2. (1430 aa)
	EDN1	EDN1 isoform 1. (212 aa)
	FBXO5	F-box protein 5. (447 aa)
	ZP3	POMZP3 isoform 1. (424 aa)
	POMZP3	ZP3 isoform 1. (254 aa)
	STRA8	Stimulated by retinoic acid 8. (330 aa)
	NOBOX	NOBOX isoform 1. (690 aa)
	NPM2	Nucleophosmin/nucleoplasmin 2. (213 aa)
	PTK2B	PTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	DMRT1	Doublesex and mab-3 related transcription factor 1. (371 aa)
	SOHLH1	Spermatogenesis and oogenesis specific basic helix-loop-helix 1. (387 aa)
	KMT2D	KMT2D isoform 2. (5542 aa)
	CDC25B	Cell division cycle 25 homolog B. (580 aa)
	TDRD15	Tudor domain containing 15. (1934 aa)
	PDE5A	Phosphodiesterase. (875 aa)
	MEI4	Meiotic double-stranded break formation protein 4. (385 aa)
	INHBB	Inhibin subunit beta B. (407 aa)
	REC8	Meiotic recombination protein REC8-like 1. (547 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	HEXB	Beta-hexosaminidase. (557 aa)
	TDRD6	Tudor domain containing 6. (2097 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (595 aa)
	MDK	Midkine (Neurite growth-promoting factor 2). (143 aa)
	LOC738663	Tubulin beta-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Has a key role in meiotic spindle assembly and oocyte maturation (By similarity); Belongs to the tubulin family. (444 aa)
	ENSPTRP00000083685	annotation not available (296 aa)
	TUT7	ZCCHC6 isoform 2. (1540 aa)
	CK820_G0020029	PABPC1L isoform 9. (171 aa)
	HORMAD1	HORMA domain containing 1. (394 aa)
	ENSPTRP00000081143	annotation not available (219 aa)
	PTN	PTN isoform 2. (172 aa)
	LGR5	Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
	ENSPTRP00000079023	annotation not available (237 aa)
	ENSPTRP00000078926	annotation not available (320 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	TDRD10	Tudor domain containing 10. (366 aa)
	PAQR7	Progestin and adipoQ receptor family member VII. (346 aa)
	MTHFSD	Methenyltetrahydrofolate synthetase domain containing. (383 aa)
	ENSPTRP00000074403	annotation not available (115 aa)
	ENSPTRP00000073222	annotation not available (409 aa)
	PAQR8	Progestin and adipoQ receptor family member 8. (354 aa)
	FMN2	FMN2 isoform 6. (198 aa)
	WASHC5	WASH complex subunit 5. (1159 aa)
	TUT4	ZCCHC11 isoform 8. (1649 aa)
	DIAPH2	DIAPH2 isoform 3. (1103 aa)
	PIWIL2	Piwi-like RNA-mediated gene silencing 2; Belongs to the argonaute family. (973 aa)
	PLD6	Phospholipase D family member 6. (252 aa)
	TDRKH	Tudor and KH domain containing. (605 aa)
	PAQR6	Progestin and adipoQ receptor family member 6. (351 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	ENSPTRP00000063325	annotation not available (373 aa)
	RPS6KA2	Ribosomal protein S6 kinase alpha-2 isoform X1. (758 aa)
	ENSPTRP00000062821	annotation not available (220 aa)
	TAF4B	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa. (862 aa)
	PAQR6-2	Progestin and adipoQ receptor family member 6. (363 aa)
	SEBOX	Homeobox protein SEBOX. (190 aa)
	RPS6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
	BHMG1	BHMG1 isoform 1. (638 aa)
	PAQR5	Progestin and adipoQ receptor family member V. (329 aa)
	ZGLP1	Zinc finger, GATA-like protein 1. (271 aa)
	CCDC36	Coiled-coil domain containing 36. (595 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	YTHDC1	YTH domain containing 1. (735 aa)
	ASPM	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3477 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1267 aa)
	TNFAIP6	Tumor necrosis factor, alpha-induced protein 6. (277 aa)
	TDRD7	Tudor domain containing 7. (1098 aa)
	MEIOC	Meiosis specific with coiled-coil domain. (952 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	WDR77	Methylosome protein 50. (342 aa)
	DDX20	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20. (861 aa)
	TDRD5	Tudor domain containing 5. (1035 aa)
	CK820_G0023253	FMN2 isoform 2. (1196 aa)
	PANX1	Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMH	BMPR1B	ENSPTRP00000017388	ENSPTRP00000027988	Anti-Mullerian hormone.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.805
AMH	DMRT1	ENSPTRP00000017388	ENSPTRP00000035458	Anti-Mullerian hormone.	Doublesex and mab-3 related transcription factor 1.	0.529
AMH	INHBB	ENSPTRP00000017388	ENSPTRP00000090910	Anti-Mullerian hormone.	Inhibin subunit beta B.	0.499
AMH	WNT4	ENSPTRP00000017388	ENSPTRP00000063328	Anti-Mullerian hormone.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.701
ASPM	AURKC	ENSPTRP00000051373	ENSPTRP00000019871	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	AURKC isoform 1; Belongs to the protein kinase superfamily.	0.646
ASPM	ENSPTRP00000073222	ENSPTRP00000051373	ENSPTRP00000073222	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	annotation not available	0.516
ASPM	FBXO5	ENSPTRP00000051373	ENSPTRP00000031946	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	F-box protein 5.	0.418
ASPM	TRIP13	ENSPTRP00000051373	ENSPTRP00000028622	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.516
ATM	BCL2	ENSPTRP00000054216	ENSPTRP00000090293	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.536
ATM	BRCA2	ENSPTRP00000054216	ENSPTRP00000009812	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Breast cancer 2, early onset.	0.983
ATM	CTNNB1	ENSPTRP00000054216	ENSPTRP00000044466	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.504
ATM	DMC1	ENSPTRP00000054216	ENSPTRP00000024757	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.922
ATM	ERCC1	ENSPTRP00000054216	ENSPTRP00000076815	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.772
ATM	MLH1	ENSPTRP00000054216	ENSPTRP00000025426	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MutL homolog 1, colon cancer, nonpolyposis type 2.	0.945
ATM	SPO11	ENSPTRP00000054216	ENSPTRP00000023491	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SPO11 initiator of meiotic double stranded breaks.	0.693
ATM	SRC	ENSPTRP00000054216	ENSPTRP00000076797	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.521
AURKC	ASPM	ENSPTRP00000019871	ENSPTRP00000051373	AURKC isoform 1; Belongs to the protein kinase superfamily.	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	0.646
AURKC	ENSPTRP00000073222	ENSPTRP00000019871	ENSPTRP00000073222	AURKC isoform 1; Belongs to the protein kinase superfamily.	annotation not available	0.401
AURKC	TRIP13	ENSPTRP00000019871	ENSPTRP00000028622	AURKC isoform 1; Belongs to the protein kinase superfamily.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.401
BCL2	ATM	ENSPTRP00000090293	ENSPTRP00000054216	BCL2 apoptosis regulator.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.536