53 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1246 aa)
	HOXA3	HOXA3 isoform 3. (443 aa)
	ENSPTRP00000066724	annotation not available (166 aa)
	GATA3	GATA binding protein 3. (444 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (955 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	CK820_G0012168	ABL1 isoform 3. (1149 aa)
	ENSPTRP00000061568	annotation not available (353 aa)
	PBX1	Pre-B-cell leukemia homeobox 1. (486 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (676 aa)
	MAD1L1	MAD1 mitotic arrest deficient-like 1. (718 aa)
	CACNB4	Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	BCL11B	BAF chromatin remodeling complex subunit BCL11B. (894 aa)
	MAFB	V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (Avian). (323 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	CRKL	V-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
	FOXE1	FOXE1 isoform 1. (371 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	SIX4	SIX homeobox 4. (781 aa)
	SLC46A2	Solute carrier family 46 member 2. (475 aa)
	SRF	Serum response factor (C-fos serum response element-binding transcription factor). (508 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	TBX1	TBX1 isoform 1. (478 aa)
	AIRE	Autoimmune regulator. (545 aa)
	SIX1	SIX homeobox 1. (284 aa)
	HOXA3-2	Homeobox A3. (443 aa)
	ASXL1	ASXL transcriptional regulator 1. (1548 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	LMO4	LIM domain only 4. (165 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (518 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	CCNB2	CCNB2 isoform 1; Belongs to the cyclin family. (398 aa)
	CTC1	CTS telomere maintenance complex component 1. (1159 aa)
	FOXN1	FOXN1 isoform 2. (648 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	PRDX2	PRDX2 isoform 1. (198 aa)
	PAX1	PAX1 isoform 1. (457 aa)
	ENSPTRP00000090382	annotation not available (493 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	EPHB3	EPHB3 isoform 1. (1031 aa)
	ENSPTRP00000089450	annotation not available (303 aa)
	BRAF-2	BRAF isoform 2. (766 aa)
	RAF1	RAF1 isoform 2; Belongs to the protein kinase superfamily. (668 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
	BRAF	BRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ASXL1	ENSPTRP00000072918	ENSPTRP00000071060	Tyrosine-protein kinase.	ASXL transcriptional regulator 1.	0.475
ABL1	ATM	ENSPTRP00000072918	ENSPTRP00000054216	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.940
ABL1	BCL2	ENSPTRP00000072918	ENSPTRP00000090293	Tyrosine-protein kinase.	BCL2 apoptosis regulator.	0.497
ABL1	BCL2L11	ENSPTRP00000072918	ENSPTRP00000076253	Tyrosine-protein kinase.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.412
ABL1	CRKL	ENSPTRP00000072918	ENSPTRP00000046677	Tyrosine-protein kinase.	V-crk sarcoma virus CT10 oncogene homolog (Avian)-like.	0.985
ABL1	CTNNB1	ENSPTRP00000072918	ENSPTRP00000044466	Tyrosine-protein kinase.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.785
ABL1	ENSPTRP00000089450	ENSPTRP00000072918	ENSPTRP00000089450	Tyrosine-protein kinase.	annotation not available	0.861
ABL1	EPHB3	ENSPTRP00000072918	ENSPTRP00000072944	Tyrosine-protein kinase.	EPHB3 isoform 1.	0.928
ABL1	MAPK1	ENSPTRP00000072918	ENSPTRP00000024313	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.657
ABL1	MAPK3	ENSPTRP00000072918	ENSPTRP00000053615	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.450
ABL1	PBX1	ENSPTRP00000072918	ENSPTRP00000061415	Tyrosine-protein kinase.	Pre-B-cell leukemia homeobox 1.	0.470
AIRE	FOXN1	ENSPTRP00000024049	ENSPTRP00000015225	Autoimmune regulator.	FOXN1 isoform 2.	0.522
ASXL1	ABL1	ENSPTRP00000071060	ENSPTRP00000072918	ASXL transcriptional regulator 1.	Tyrosine-protein kinase.	0.475
ASXL1	CK820_G0012168	ENSPTRP00000071060	ENSPTRP00000061635	ASXL transcriptional regulator 1.	ABL1 isoform 3.	0.475
ASXL1	CTC1	ENSPTRP00000071060	ENSPTRP00000014881	ASXL transcriptional regulator 1.	CTS telomere maintenance complex component 1.	0.672
ASXL1	JARID2	ENSPTRP00000071060	ENSPTRP00000068115	ASXL transcriptional regulator 1.	Jumonji and AT-rich interaction domain containing 2.	0.620
ATM	ABL1	ENSPTRP00000054216	ENSPTRP00000072918	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.940
ATM	BCL2	ENSPTRP00000054216	ENSPTRP00000090293	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.536
ATM	BRAF	ENSPTRP00000054216	ENSPTRP00000079485	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRAF isoform 1; Belongs to the protein kinase superfamily.	0.619
ATM	BRAF-2	ENSPTRP00000054216	ENSPTRP00000089230	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRAF isoform 2.	0.619