STRINGSTRING
BMP4 BMP4 HLX HLX DACT1 DACT1 HIF1A HIF1A RBPMS2 RBPMS2 FOXF1 FOXF1 SIX2 SIX2 HOXD13 HOXD13 IHH IHH TP63 TP63 BBS7 BBS7 SFRP2 SFRP2 TCF21 TCF21 AHI1 AHI1 AGR2 AGR2 GLI3 GLI3 SOX17 SOX17 NOTCH1 NOTCH1 GLI2 GLI2 SOX10 SOX10 CTNNB1 CTNNB1 HOXA13-2 HOXA13-2 NIPBL NIPBL SFRP1 SFRP1 BCL2 BCL2 WNT5A WNT5A ENSPTRP00000084126 ENSPTRP00000084126 PERCC1 PERCC1 SMAD3 SMAD3 FGF10 FGF10 EPB41L5 EPB41L5 SMAD2 SMAD2 HOXA13 HOXA13 EGFR EGFR EPHB3 EPHB3 NKX2-3 NKX2-3 SHH SHH GATA4 GATA4 ACVR2B ACVR2B GLI1 GLI1 STRA6 STRA6 BMP4-2 BMP4-2 OVOL2 OVOL2 SHOX2 SHOX2 SOX11 SOX11 NODAL NODAL FGFR2 FGFR2 ID2 ID2 WNT11 WNT11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP4Bone morphogenetic protein 4. (408 aa)
HLXH2.0-like homeobox. (493 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (836 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (209 aa)
FOXF1FOXF1 isoform 1. (433 aa)
SIX2SIX homeobox 2. (291 aa)
HOXD13HOXD13 isoform 1. (344 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
TCF21Transcription factor 21. (179 aa)
AHI1Abelson helper integration site 1. (1196 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
SOX17SOX17 isoform 1. (416 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
GLI2GLI family zinc finger 2. (1587 aa)
SOX10SRY-box transcription factor 10. (466 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
NIPBLNipped-B protein. (2804 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSPTRP00000084126annotation not available (117 aa)
PERCC1T0176695 isoform 1. (263 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
HOXA13Homeobox A13. (388 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
EPHB3EPHB3 isoform 1. (1031 aa)
NKX2-3NKX2-3 isoform 1. (366 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
GATA4GATA binding protein 4. (443 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
GLI1GLI family zinc finger 1. (1106 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
SHOX2SHOX2 isoform 2. (343 aa)
SOX11Transcription factor SOX. (441 aa)
NODALNODAL isoform 2. (347 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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