27 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TH	Tyrosine hydroxylase. (528 aa)
	KDM2B	Lysine (K)-specific demethylase 2B. (1336 aa)
	ALDH1A3	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	SIX3	SIX homeobox 3. (331 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1198 aa)
	TWIST1	TWIST1 isoform 2. (163 aa)
	FOXF2	FOXF2 isoform 1. (444 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1127 aa)
	TFAP2A	Transcription factor AP-2 alpha. (439 aa)
	PHACTR4	Phosphatase and actin regulator. (712 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	ENSPTRP00000066621	annotation not available (709 aa)
	IFT172	Intraflagellar transport 172 homolog. (1767 aa)
	STRA6	Stimulated by retinoic acid 6. (706 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	SP3	Sp3 transcription factor. (781 aa)
	PAX2	PAX2 isoform 1. (417 aa)
	SOX11	Transcription factor SOX. (441 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (521 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	HIPK1	HIPK1 isoform 10. (1210 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A3	STRA6	ENSPTRP00000012824	ENSPTRP00000079348	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family.	Stimulated by retinoic acid 6.	0.507
BMP7	CITED2	ENSPTRP00000023489	ENSPTRP00000081552	Bone morphogenetic protein 7.	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	0.416
BMP7	PAX2	ENSPTRP00000023489	ENSPTRP00000091068	Bone morphogenetic protein 7.	PAX2 isoform 1.	0.457
CITED2	BMP7	ENSPTRP00000081552	ENSPTRP00000023489	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Bone morphogenetic protein 7.	0.416
CITED2	TFAP2A	ENSPTRP00000081552	ENSPTRP00000087495	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Transcription factor AP-2 alpha.	0.890
FZD5	WNT16	ENSPTRP00000021982	ENSPTRP00000033610	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.889
FZD5	WNT5A	ENSPTRP00000021982	ENSPTRP00000086163	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.995
HIPK1	HIPK2	ENSPTRP00000001943	ENSPTRP00000033846	HIPK1 isoform 10.	Homeodomain interacting protein kinase 2.	0.901
HIPK2	HIPK1	ENSPTRP00000033846	ENSPTRP00000001943	Homeodomain interacting protein kinase 2.	HIPK1 isoform 10.	0.901
IHH	TFAP2A	ENSPTRP00000022106	ENSPTRP00000087495	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Transcription factor AP-2 alpha.	0.408
PAX2	BMP7	ENSPTRP00000091068	ENSPTRP00000023489	PAX2 isoform 1.	Bone morphogenetic protein 7.	0.457
PAX2	PAX6	ENSPTRP00000091068	ENSPTRP00000065705	PAX2 isoform 1.	PAX6 isoform 13.	0.505
PAX6	PAX2	ENSPTRP00000065705	ENSPTRP00000091068	PAX6 isoform 13.	PAX2 isoform 1.	0.505
PAX6	PROX1	ENSPTRP00000065705	ENSPTRP00000051173	PAX6 isoform 13.	Prospero homeobox 1.	0.478
PAX6	SIX3	ENSPTRP00000065705	ENSPTRP00000020406	PAX6 isoform 13.	SIX homeobox 3.	0.799
PAX6	SOX11	ENSPTRP00000065705	ENSPTRP00000090911	PAX6 isoform 13.	Transcription factor SOX.	0.458
PROX1	PAX6	ENSPTRP00000051173	ENSPTRP00000065705	Prospero homeobox 1.	PAX6 isoform 13.	0.478
PROX1	TBX2	ENSPTRP00000051173	ENSPTRP00000016104	Prospero homeobox 1.	T-box transcription factor 2.	0.484
SIX3	PAX6	ENSPTRP00000020406	ENSPTRP00000065705	SIX homeobox 3.	PAX6 isoform 13.	0.799
SOX11	PAX6	ENSPTRP00000090911	ENSPTRP00000065705	Transcription factor SOX.	PAX6 isoform 13.	0.458