STRINGSTRING
AKT1 AKT1 ENSPTRP00000084090 ENSPTRP00000084090 ENSPTRP00000084830 ENSPTRP00000084830 ACTN3 ACTN3 ENSPTRP00000086254 ENSPTRP00000086254 DBN1 DBN1 WT1 WT1 OCM-2 OCM-2 LOC100615317 LOC100615317 UNC13A UNC13A STAT5B STAT5B ENSPTRP00000089337 ENSPTRP00000089337 BCL2 BCL2 MEF2C MEF2C TSHR TSHR SYT17 SYT17 CREB1 CREB1 EZR EZR LIMK1 LIMK1 RUFY3 RUFY3 NRG1 NRG1 MUL1 MUL1 LPAR3 LPAR3 CRABP2 CRABP2 SYT2 SYT2 HLX HLX NRP1 NRP1 BMPR1A BMPR1A ZFYVE27 ZFYVE27 GPAM GPAM FGFR2 FGFR2 MYOD1 MYOD1 RAG2 RAG2 YAP1 YAP1 YBX3 YBX3 RASAL1 RASAL1 FGF9 FGF9 PARP2 PARP2 CPNE6 CPNE6 AKAP6 AKAP6 CYFIP1 CYFIP1 PPIB PPIB SEMA7A SEMA7A BBS2 BBS2 SOX15 SOX15 NDEL1 NDEL1 NTN1 NTN1 TRPV2 TRPV2 MAPT MAPT WNT3 WNT3 RPS6KB1 RPS6KB1 TBX2 TBX2 GATA6 GATA6 SYT4 SYT4 SMAD7 SMAD7 HAMP HAMP MEGF8 MEGF8 SYT3 SYT3 CACNG7 CACNG7 ITSN2 ITSN2 VIL1 VIL1 PLCB1 PLCB1 MKKS MKKS FOXS1 FOXS1 GHRH GHRH ADNP ADNP CDH4 CDH4 DSCAM DSCAM CPNE9 CPNE9 TWF2 TWF2 PLS1 PLS1 SERP1 SERP1 GHSR GHSR MAP3K13 MAP3K13 POU4F2 POU4F2 SLC6A3 SLC6A3 SEMA5A SEMA5A MAP1B MAP1B EFNA5 EFNA5 EDN1 EDN1 MAPK14 MAPK14 CPNE5 CPNE5 PIM1 PIM1 SRF SRF HEY2 HEY2 PRKN PRKN DLL1 DLL1 OCM OCM AGR2 AGR2 TBX20 TBX20 DBNL DBNL ZP3 ZP3 POMZP3 POMZP3 OCM2 OCM2 WNT2 WNT2 SMO SMO CHD7 CHD7 RIMS2 RIMS2 PLAA PLAA RABGAP1 RABGAP1 NOTCH1 NOTCH1 ANAPC2 ANAPC2 CDKL5 CDKL5 TRPC5 TRPC5 SASH3 SASH3 NOL12 NOL12 AGRN AGRN FN1 FN1 BCL11A BCL11A PPARD PPARD SYT1 SYT1 ATP8A2 ATP8A2 SMURF1 SMURF1 NIPBL NIPBL BMPR2 BMPR2 SEMA4D SEMA4D CDK1 CDK1 WNT3A WNT3A PROX1 PROX1 LOC453361 LOC453361 BBS4 BBS4 SHTN1 SHTN1 BDNF BDNF GOLGA4 GOLGA4 MACF1 MACF1 NEDD4L NEDD4L INSR INSR ERBB4 ERBB4 ENSPTRP00000063325 ENSPTRP00000063325 IST1 IST1 GHRHR GHRHR ENSPTRP00000064416 ENSPTRP00000064416 CK820_G0046635 CK820_G0046635 HOPX HOPX TGFBR3 TGFBR3 SMO-2 SMO-2 BASP1 BASP1 IGF1 IGF1 CXCL12 CXCL12 PEX5 PEX5 ENSPTRP00000068866 ENSPTRP00000068866 TBX5 TBX5 RND2 RND2 DRD2 DRD2 CSF1 CSF1 NGF NGF OCM2-2 OCM2-2 ARX ARX MTM1 MTM1 NDEL1-2 NDEL1-2 SLC23A2 SLC23A2 LEP LEP GHRHR-2 GHRHR-2 GHR GHR SPTBN4 SPTBN4 ZFPM2 ZFPM2 TGFBR2 TGFBR2 FGF8 FGF8 RIMS1 RIMS1 GHRL GHRL WNT3-2 WNT3-2 GLI1 GLI1 BMP10 BMP10 DBNL-2 DBNL-2 DISC1 DISC1 IGF2 IGF2 IL7 IL7 RBPJ RBPJ LIMK1-2 LIMK1-2 ACACB ACACB L1CAM L1CAM ENSPTRP00000080680 ENSPTRP00000080680 CK820_G0015962 CK820_G0015962 RNF157 RNF157
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
ENSPTRP00000084090annotation not available (121 aa)
ENSPTRP00000084830annotation not available (340 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (944 aa)
ENSPTRP00000086254Microtubule-associated protein tau. (776 aa)
DBN1DBN1 isoform 1. (695 aa)
WT1WT1 transcription factor. (514 aa)
OCM-2Oncomodulin. (136 aa)
LOC100615317IST1 isoform 5. (331 aa)
UNC13AUNC13A isoform 2. (1693 aa)
STAT5BSignal transducer and activator of transcription. (772 aa)
ENSPTRP00000089337annotation not available (2012 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
SYT17Synaptotagmin 17. (481 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
EZREZR isoform 1. (671 aa)
LIMK1LIM domain kinase 1. (677 aa)
RUFY3RUN and FYVE domain containing 3. (638 aa)
NRG1NRG1 isoform 3. (713 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
LPAR3Lysophosphatidic acid receptor 3. (353 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
SYT2Synaptotagmin 2. (419 aa)
HLXH2.0-like homeobox. (493 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (416 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
RAG2Recombination activating 2. (527 aa)
YAP1Yes-associated protein 1. (508 aa)
YBX3Cold shock domain protein A. (374 aa)
RASAL1RAS protein activator like 1. (806 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PARP2Poly [ADP-ribose] polymerase. (570 aa)
CPNE6CPNE6 isoform 2. (565 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
SEMA7ASEMA7A isoform 1; Belongs to the semaphorin family. (664 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
SOX15SOX15 isoform 1. (233 aa)
NDEL1NudE nuclear distribution gene E homolog-like 1. (345 aa)
NTN1NTN1 isoform 1. (604 aa)
TRPV2Transient receptor potential cation channel, subfamily V, member 2; Belongs to the transient receptor (TC 1.A.4) family. (764 aa)
MAPTMicrotubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabili [...] (776 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
TBX2T-box transcription factor 2. (712 aa)
GATA6GATA binding protein 6. (594 aa)
SYT4Synaptotagmin 4. (425 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
SYT3Synaptotagmin 3. (590 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
ITSN2ITSN2 isoform 1. (1684 aa)
VIL1VIL1 isoform 1. (827 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
FOXS1FOXS1 isoform 1. (330 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
ADNPActivity-dependent neuroprotector homeobox. (1102 aa)
CDH4CDH4 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (916 aa)
DSCAMDS cell adhesion molecule. (2012 aa)
CPNE9Copine family member 9. (553 aa)
TWF2T0016682 isoform 2. (349 aa)
PLS1Plastin 1 (I isoform). (629 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
POU4F2POU domain protein. (406 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
SEMA5ASEMA5A isoform 1. (1074 aa)
MAP1BMicrotubule associated protein 1B. (2468 aa)
EFNA5EFNA5 isoform 1; Belongs to the ephrin family. (228 aa)
EDN1EDN1 isoform 1. (212 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
CPNE5CPNE5 isoform 2. (593 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (535 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
OCMOCM isoform 1; Belongs to the parvalbumin family. (109 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
TBX20T-box transcription factor 20. (447 aa)
DBNLDBNL isoform 5. (439 aa)
ZP3POMZP3 isoform 1. (424 aa)
POMZP3ZP3 isoform 1. (254 aa)
OCM2OCM2 isoform 1; Belongs to the parvalbumin family. (109 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
CHD7CHD7 isoform 1. (2997 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1367 aa)
PLAAPhospholipase A2-activating protein. (795 aa)
RABGAP1Rab GTPase-activating protein 1 isoform X1. (1085 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
CDKL5Cyclin dependent kinase like 5. (1030 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (973 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
NOL12T0096363 isoform 1. (213 aa)
AGRNAGRN isoform 2. (2066 aa)
FN1FN1 isoform 1. (2477 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (835 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
SYT1Synaptotagmin 1. (422 aa)
ATP8A2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1188 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
NIPBLNipped-B protein. (2804 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
SEMA4DSEMA4D isoform 13; Belongs to the semaphorin family. (862 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PROX1Prospero homeobox 1. (737 aa)
LOC453361CAPN3 isoform 4; Belongs to the peptidase C2 family. (821 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
SHTN1SHTN1 isoform 3. (636 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
GOLGA4GOLGA4 isoform 4. (2243 aa)
MACF1Microtubule actin crosslinking factor 1. (7594 aa)
NEDD4LNEDD4L isoform 6. (1254 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
ENSPTRP00000063325annotation not available (373 aa)
IST1IST1 factor associated with ESCRT-III. (376 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
ENSPTRP00000064416annotation not available (502 aa)
CK820_G0046635NACA isoform 1. (1839 aa)
HOPXHOPX isoform 3. (112 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
BASP1Brain abundant, membrane attached signal protein 1. (226 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
PEX5Peroxisomal biogenesis factor 5. (639 aa)
ENSPTRP00000068866annotation not available (532 aa)
TBX5T-box transcription factor 5. (518 aa)
RND2Rho family GTPase 2. (227 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
OCM2-2Putative oncomodulin-2 isoform X1. (136 aa)
ARXARX isoform 1. (559 aa)
MTM1MTM1 isoform 1. (745 aa)
NDEL1-2NudE nuclear distribution gene E homolog-like 1. (351 aa)
SLC23A2Solute carrier family 23 (Nucleobase transporters), member 2. (650 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
GHRHR-2Growth hormone-releasing hormone receptor isoform X1. (447 aa)
GHRGrowth hormone receptor. (645 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (2565 aa)
ZFPM2ZFPM2 isoform 3. (1151 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1692 aa)
GHRLGHRL isoform 10. (117 aa)
WNT3-2Wnt family member 3. (290 aa)
GLI1GLI family zinc finger 1. (1106 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
DBNL-2Drebrin like. (439 aa)
DISC1Disrupted in schizophrenia 1 protein isoform X1. (977 aa)
IGF2Insulin like growth factor 2. (236 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (179 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
LIMK1-2LIM domain kinase 1. (677 aa)
ACACBACACB isoform 2. (2458 aa)
L1CAML1 cell adhesion molecule. (1257 aa)
ENSPTRP00000080680annotation not available (560 aa)
CK820_G0015962ACACB isoform 16. (191 aa)
RNF157Ring finger protein 157. (685 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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