44 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	FOLR1	Folate receptor alpha. (257 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (268 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	AXIN2	AXIN2 isoform 1. (843 aa)
	GATA6	GATA binding protein 6. (594 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	NTF4	NTF4 isoform 1; Belongs to the NGF-beta family. (210 aa)
	LRP2	LRP2 isoform 1. (4655 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	LEMD2	LEM domain containing 2. (503 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
	SOX17	SOX17 isoform 1. (416 aa)
	RDH10	Retinol dehydrogenase 10 (All-trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	FOXH1	FOXH1 isoform 1. (365 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	TBR1	T-box brain transcription factor 1. (682 aa)
	FOXH1-2	Forkhead box H1. (365 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	ENSPTRP00000064416	annotation not available (502 aa)
	HOXA3	HOXA3 isoform 3. (443 aa)
	NKX3-2	NKX3-2 isoform 1. (333 aa)
	HOXA3-2	Homeobox A3. (443 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
	PAX2	PAX2 isoform 1. (417 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	RBM20	RNA binding motif protein 20. (1261 aa)
	AR	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
	SMARCD3-2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (500 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	SELENOH	Selenoprotein H. (121 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	PAX8	PAX8 isoform 1. (456 aa)
	EMP2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins. Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T- cell mediated cytotoxicity. R [...] (167 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CTNNB1	ENSPTRP00000076864	ENSPTRP00000044466	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.960
AR	MAPK3	ENSPTRP00000076864	ENSPTRP00000053615	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.557
AXIN2	BMP4	ENSPTRP00000016228	ENSPTRP00000010780	AXIN2 isoform 1.	Bone morphogenetic protein 4.	0.455
AXIN2	BMP4-2	ENSPTRP00000016228	ENSPTRP00000080656	AXIN2 isoform 1.	Bone morphogenetic protein 4.	0.455
AXIN2	BMPR1A	ENSPTRP00000016228	ENSPTRP00000004727	AXIN2 isoform 1.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.419
AXIN2	CTNNB1	ENSPTRP00000016228	ENSPTRP00000044466	AXIN2 isoform 1.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.997
AXIN2	ENSPTRP00000064416	ENSPTRP00000016228	ENSPTRP00000064416	AXIN2 isoform 1.	annotation not available	0.419
AXIN2	LRP2	ENSPTRP00000016228	ENSPTRP00000021546	AXIN2 isoform 1.	LRP2 isoform 1.	0.530
AXIN2	SHH	ENSPTRP00000016228	ENSPTRP00000075730	AXIN2 isoform 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.484
AXIN2	WNT11	ENSPTRP00000016228	ENSPTRP00000007028	AXIN2 isoform 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.574
AXIN2	WNT5A	ENSPTRP00000016228	ENSPTRP00000086163	AXIN2 isoform 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.639
BMP4	AXIN2	ENSPTRP00000010780	ENSPTRP00000016228	Bone morphogenetic protein 4.	AXIN2 isoform 1.	0.455
BMP4	BMPR1A	ENSPTRP00000010780	ENSPTRP00000004727	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.988
BMP4	CTNNB1	ENSPTRP00000010780	ENSPTRP00000044466	Bone morphogenetic protein 4.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.551
BMP4	ENSPTRP00000064416	ENSPTRP00000010780	ENSPTRP00000064416	Bone morphogenetic protein 4.	annotation not available	0.846
BMP4	FGF10	ENSPTRP00000010780	ENSPTRP00000083399	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.696
BMP4	FGFR2	ENSPTRP00000010780	ENSPTRP00000005308	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.492
BMP4	GATA6	ENSPTRP00000010780	ENSPTRP00000016858	Bone morphogenetic protein 4.	GATA binding protein 6.	0.546
BMP4	ISL1	ENSPTRP00000010780	ENSPTRP00000028882	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.409
BMP4	NOG	ENSPTRP00000010780	ENSPTRP00000016018	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.998