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| | ITGA2 | Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa) |
| | JAK2 | Tyrosine-protein kinase. (1143 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (619 aa) |
| | ELN | ELN isoform 3. (790 aa) |
| | BMP4-2 | Bone morphogenetic protein 4. (408 aa) |
| | HES5-2 | Hes family bHLH transcription factor 5. (165 aa) |
| | PDCD4 | Programmed cell death 4 (Neoplastic transformation inhibitor). (469 aa) |
| | APOD | Apolipoprotein D. (215 aa) |
| | IL6-2 | Interleukin 6. (234 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (977 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa) |
| | ENSPTRP00000079495 | annotation not available (194 aa) |
| | CTNNBIP1 | Catenin, beta interacting protein 1. (81 aa) |
| | PDGFD | Platelet derived growth factor D. (370 aa) |
| | SRC | Tyrosine-protein kinase. (542 aa) |
| | NDRG2 | Protein NDRG2; Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). (371 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma isoform X2. (505 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1374 aa) |
| | TPM1 | TPM1 isoform 3; Belongs to the tropomyosin family. (326 aa) |
| | HES5 | Hes family bHLH transcription factor 5. (165 aa) |
| | IRAK1-2 | Interleukin-1 receptor-associated kinase 1. (712 aa) |
| | ACE2 | Angiotensin-converting enzyme. (805 aa) |
| | DBH | Dopamine beta-hydroxylase. (617 aa) |
| | OGN | OGN isoform 2. (298 aa) |
| | CCN4 | WISP1 isoform 1. (367 aa) |
| | TRIB1 | Tribbles pseudokinase 1. (372 aa) |
| | VIPR2 | VIPR2 isoform 3; Belongs to the G-protein coupled receptor 2 family. (579 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa) |
| | IGFBP3 | Insulin like growth factor binding protein 3. (291 aa) |
| | GNA12 | Guanine nucleotide binding protein (G protein) alpha 12. (381 aa) |
| | VIP | Vasoactive intestinal peptide. (169 aa) |
| | TNFAIP3 | Tumor necrosis factor, alpha-induced protein 3. (790 aa) |
| | HTR1B | 5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (390 aa) |
| | AIF1 | Allograft inflammatory factor 1. (147 aa) |
| | EDN1 | EDN1 isoform 1. (212 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) |
| | HBEGF | Heparin-binding EGF-like growth factor. (208 aa) |
| | TERT-2 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (762 aa) |
| | HPGD | 15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa) |
| | NPY5R | Neuropeptide Y receptor type 5. (445 aa) |
| | EREG | EREG isoform 1. (169 aa) |
| | PPARGC1A | PPARG coactivator 1 alpha. (809 aa) |
| | ADIPOQ | Adiponectin, C1Q and collagen domain containing. (244 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | GNAI2 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa) |
| | HMOX1 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa) |
| | ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1. (967 aa) |
| | MMP9 | Matrix metallopeptidase 9. (699 aa) |
| | BMP2 | Bone morphogenetic protein 2. (398 aa) |
| | NPPC | Natriuretic peptide C. (126 aa) |
| | IGFBP5 | Insulin-like growth factor-binding protein 5. (272 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | TACR1 | Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa) |
| | CCDC142 | Coiled-coil domain containing 142. (750 aa) |
| | ID2 | Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | NOTCH3 | NOTCH3 isoform 1. (2321 aa) |
| | ELANE | Elastase, neutrophil expressed. (267 aa) |
| | GNA13 | Guanine nucleotide binding protein (G protein), alpha 13. (377 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | PHB | Prohibitin. (272 aa) |
| | NF1 | Neurofibromin 1. (2839 aa) |
| | MYOCD | MYOCD isoform 2. (986 aa) |
| | ALOX12 | Arachidonate 12-lipoxygenase, 12S type. (663 aa) |
| | CDH13 | CDH13 isoform 2. (760 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (655 aa) |
| | NDRG4 | NDRG family member 4. (226 aa) |
| | CX3CL1 | Chemokine (C-X3-C motif) ligand 1. (397 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1364 aa) |
| | RBPMS2 | RNA binding protein, mRNA processing factor 2. (209 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | BMP4 | Bone morphogenetic protein 4. (408 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa) |
| | IRAK4 | Interleukin-1 receptor-associated kinase 4. (460 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa) |
| | FOXJ2 | FOXJ2 isoform 1. (573 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | P2RY6 | Pyrimidinergic receptor P2Y6. (328 aa) |
| | EFEMP2 | EGF containing fibulin-like extracellular matrix protein 2. (443 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (841 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | PRKG1 | cGMP-dependent protein kinase. (686 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | PTGS2 | Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa) |
| | DDR2 | Discoidin domain receptor tyrosine kinase 2. (855 aa) |
| | IL6R | Interleukin 6 receptor. (442 aa) |
| | NPR1 | Guanylate cyclase. (1061 aa) |
| | GNAI3 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa) |
| | PTAFR | Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa) |
| | LDLRAP1 | Low density lipoprotein receptor adaptor protein 1. (308 aa) |
| | MFN2 | MFN2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa) |
| | ENSPTRP00000064416 | annotation not available (502 aa) |
| | ENSPTRP00000063164 | annotation not available (1061 aa) |
| | NOX1 | NADPH oxidase 1. (564 aa) |
| | ENSPTRP00000062123 | annotation not available (256 aa) |
| | TERT | Telomerase reverse transcriptase. (360 aa) |
| | CALCRL | CALCRL isoform 1; Belongs to the G-protein coupled receptor 2 family. (478 aa) |
| | S1PR1 | Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa) |
| | ENSPTRP00000056956 | annotation not available (225 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic polypeptide; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | CTNNB1 | Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa) |
| | PPARD | Peroxisome proliferator-activated receptor delta. (441 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa) |
| | FOXP1 | FOXP1 isoform 2. (693 aa) |
| | ENSPTRP00000074974 | annotation not available (225 aa) |
| | MEF2D | Myocyte enhancer factor 2D. (521 aa) |
| | ZNF143 | Zinc finger protein 143. (638 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (609 aa) |
| | XRCC6-2 | X-ray repair complementing defective repair in Chinese hamster cells 6. (609 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | NPR3 | Natriuretic peptide receptor 3. (541 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | ENSPTRP00000068511 | annotation not available (353 aa) |
| | ITGB3 | Integrin beta-3 isoform X2. (837 aa) |
| | IL6 | Interleukin 6 (Interferon, beta 2). (234 aa) |
| | IL15 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | IGF1 | Insulin-like growth factor 1 (Somatomedin C). (196 aa) |
| | LOC748850 | HDAC2 isoform 9. (445 aa) |
| | ANG | Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity). (147 aa) |
| | TAFA5 | FAM19A5 isoform 1. (181 aa) |
| | LOC736481 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (400 aa) |
| | THBS1 | Thrombospondin 1. (1173 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1674 aa) |
| | XBP1 | XBP1 isoform 4. (381 aa) |
| | ENSPTRP00000093159 | annotation not available (532 aa) |
| | ENSPTRP00000093022 | annotation not available (563 aa) |
| | MNAT1 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa) |
| | PTGIR | Prostaglandin I2 (Prostacyclin) receptor (IP). (386 aa) |
| | CYBA | Cytochrome b-245 alpha chain. (210 aa) |
| | STAT1 | Signal transducer and activator of transcription. (758 aa) |
| | SERPINF2 | Serpin family F member 2; Belongs to the serpin family. (491 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (483 aa) |
| | FRS2 | Fibroblast growth factor receptor substrate 2. (521 aa) |
| | CNN1 | Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (299 aa) |
| | SF1 | Splicing factor 1. (675 aa) |
| | ENSPTRP00000089473 | annotation not available (177 aa) |
| | MMP2 | Matrix metallopeptidase 2. (660 aa) |
| | ENSPTRP00000087328 | annotation not available (242 aa) |
| | RBM10 | RNA binding motif protein 10. (1006 aa) |
| | ENSPTRP00000086328 | annotation not available (580 aa) |
| | DNMT1-2 | DNA methyltransferase 1. (1674 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa) |
| | ENSPTRP00000084126 | annotation not available (117 aa) |
| | NR4A3 | Nuclear receptor subfamily 4 group A member 3. (637 aa) |
| | SOD2 | Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (238 aa) |
| | CCL5 | C-C motif chemokine. (91 aa) |
| | AKT1 | AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa) |
