STRINGSTRING
DLL1 DLL1 POU4F1 POU4F1 DMRTA2 DMRTA2 HOXC10 HOXC10 ISL2 ISL2 SOX9 SOX9 FKBP8 FKBP8 HOXD10 HOXD10 NKX2-2 NKX2-2 GSX2 GSX2 ISL1 ISL1 TLX3 TLX3 OLIG3 OLIG3 GLI3 GLI3 EYA1 EYA1 DMRT3 DMRT3 GLI2 GLI2 MNX1 MNX1 EHMT2 EHMT2 ATOH1 ATOH1 MYT1L MYT1L SOX1 SOX1 FOXA1 FOXA1 LHX3 LHX3 DBX1 DBX1 FEV FEV SUFU SUFU ASCL1 ASCL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
POU4F1POU domain protein. (350 aa)
DMRTA2DMRT like family A2. (539 aa)
HOXC10Homeobox protein Hox-C10. (342 aa)
ISL2ISL LIM homeobox 2. (359 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
HOXD10Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
GSX2GSX2 isoform 2. (304 aa)
ISL1ISL LIM homeobox 1. (349 aa)
TLX3TLX3 isoform 1. (291 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
GLI2GLI family zinc finger 2. (1587 aa)
MNX1Motor neuron and pancreas homeobox 1. (398 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1267 aa)
ATOH1Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). (356 aa)
MYT1LMyelin transcription factor 1 like. (1185 aa)
SOX1SOX1 isoform 1. (391 aa)
FOXA1FOXA1 isoform 1. (471 aa)
LHX3LHX3 isoform 2. (402 aa)
DBX1Developing brain homeobox 1. (345 aa)
FEVFEV transcription factor, ETS family member. (238 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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