50 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SIX1	SIX homeobox 1. (284 aa)
	ENSPTRP00000071105	annotation not available (376 aa)
	LHX1	LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
	ALX3	ALX homeobox 3. (343 aa)
	PRRX1	Paired related homeobox 1. (245 aa)
	NODAL	NODAL isoform 2. (347 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	MTHFD1	MTHFD1 isoform 1. (1020 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	IFT140	Intraflagellar transport 140 homolog. (1471 aa)
	MMP16	Matrix metallopeptidase 16 (Membrane-inserted). (609 aa)
	RDH10	Retinol dehydrogenase 10 (All-trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	HOXA2	HOXA2 isoform 1. (376 aa)
	HOXA1	HOXA1 isoform 2. (335 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like. (805 aa)
	WDR19	WD repeat domain 19. (1342 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2564 aa)
	TBX1	TBX1 isoform 1. (478 aa)
	DLX2	Distal-less homeobox 2. (328 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	WNT9B-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	HOXA1-2	Homeobox A1. (335 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	MED12	Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifi [...] (2182 aa)
	TFAP2A	Transcription factor AP-2 alpha. (439 aa)
	SMAD3	Mothers against decapentaplegic homolog. (442 aa)
	CHST11	Carbohydrate sulfotransferase. (352 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	FOXC2	Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
	PAX5	PAX5 isoform 1. (391 aa)
	NIPBL	Nipped-B protein. (2804 aa)
	TWIST1	TWIST1 isoform 2. (163 aa)
	NDST1	N-deacetylase/N-sulfotransferase (Heparan glucosaminyl) 1. (882 aa)
	GRHL2	Grainyhead like transcription factor 2. (625 aa)
	SIX4	SIX homeobox 4. (781 aa)
	SIX2	SIX homeobox 2. (291 aa)
	SLC39A1	Solute carrier family 39 (Zinc transporter), member 1. (324 aa)
	S1PR2	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	LOC104003639	Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
	EIF4A3	Uncharacterized protein; Belongs to the DEAD box helicase family. (413 aa)
	TBX15	T-box transcription factor 15. (602 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
	IRX5	Iroquois homeobox 5. (483 aa)
	TULP3	TULP3 isoform 3; Belongs to the TUB family. (501 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALX3	TBX15	ENSPTRP00000001851	ENSPTRP00000065583	ALX homeobox 3.	T-box transcription factor 15.	0.673
ALX3	TWIST1	ENSPTRP00000001851	ENSPTRP00000048124	ALX homeobox 3.	TWIST1 isoform 2.	0.408
BMP4	DLX2	ENSPTRP00000010780	ENSPTRP00000021601	Bone morphogenetic protein 4.	Distal-less homeobox 2.	0.482
BMP4	FGF8	ENSPTRP00000010780	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4	FGFR2	ENSPTRP00000010780	ENSPTRP00000005308	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.492
BMP4	RUNX2	ENSPTRP00000010780	ENSPTRP00000065999	Bone morphogenetic protein 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.732
BMP4	SMAD2	ENSPTRP00000010780	ENSPTRP00000062376	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.730
BMP4	SMAD3	ENSPTRP00000010780	ENSPTRP00000090625	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.611
BMP4	TGFBR1	ENSPTRP00000010780	ENSPTRP00000073078	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.724
BMP4	TGFBR2	ENSPTRP00000010780	ENSPTRP00000075305	Bone morphogenetic protein 4.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.482
BMP4-2	DLX2	ENSPTRP00000080656	ENSPTRP00000021601	Bone morphogenetic protein 4.	Distal-less homeobox 2.	0.482
BMP4-2	FGF8	ENSPTRP00000080656	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4-2	FGFR2	ENSPTRP00000080656	ENSPTRP00000005308	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.492
BMP4-2	RUNX2	ENSPTRP00000080656	ENSPTRP00000065999	Bone morphogenetic protein 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.732
BMP4-2	SMAD2	ENSPTRP00000080656	ENSPTRP00000062376	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.730
BMP4-2	SMAD3	ENSPTRP00000080656	ENSPTRP00000090625	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.611
BMP4-2	TGFBR1	ENSPTRP00000080656	ENSPTRP00000073078	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.724
BMP4-2	TGFBR2	ENSPTRP00000080656	ENSPTRP00000075305	Bone morphogenetic protein 4.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.482
DLX2	BMP4	ENSPTRP00000021601	ENSPTRP00000010780	Distal-less homeobox 2.	Bone morphogenetic protein 4.	0.482
DLX2	BMP4-2	ENSPTRP00000021601	ENSPTRP00000080656	Distal-less homeobox 2.	Bone morphogenetic protein 4.	0.482