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CDK20 CDK20 OSR2 OSR2 CHST11 CHST11 SHOX2 SHOX2 SOX11 SOX11 SMAD3 SMAD3 HOXD1 HOXD1 HOXB8 HOXB8 WDR60 WDR60 HOXD4 HOXD4 COL11A1 COL11A1 TFAP2A TFAP2A HOXD3 HOXD3 MBTD1 MBTD1 WNT5A WNT5A SP3 SP3 MED12 MED12 ENSPTRP00000085072 ENSPTRP00000085072 ALX4 ALX4 SULF2 SULF2 BMP4-2 BMP4-2 ENSPTRP00000080279 ENSPTRP00000080279 SATB2 SATB2 HOXA1-2 HOXA1-2 HOXD9 HOXD9 ENSPTRP00000077262 ENSPTRP00000077262 WNT9B-2 WNT9B-2 SHH SHH FGF8 FGF8 MMP16 MMP16 TGFBR2 TGFBR2 HOXC4 HOXC4 SULF1 SULF1 SCX SCX TGFBR1 TGFBR1 HOXC5 HOXC5 DEAF1 DEAF1 ENSPTRP00000071105 ENSPTRP00000071105 HOXA3-2 HOXA3-2 SIX1 SIX1 NKX3-2 NKX3-2 TULP3 TULP3 HOXA3 HOXA3 IRX5 IRX5 DLG1 DLG1 ENSPTRP00000066621 ENSPTRP00000066621 HOXA6-2 HOXA6-2 DMRT2 DMRT2 RUNX2 RUNX2 MDFI-2 MDFI-2 TBX15 TBX15 EIF4A3 EIF4A3 LOC104003639 LOC104003639 HOXB3 HOXB3 ZEB1 ZEB1 SMAD2 SMAD2 PBX1 PBX1 S1PR2 S1PR2 WNT9B WNT9B HOXA6 HOXA6 TAPT1 TAPT1 KIAA1217 KIAA1217 LHX1 LHX1 FOXC2 FOXC2 HAND2 HAND2 PAX5 PAX5 NIPBL NIPBL TWIST1 TWIST1 NDST1 NDST1 HOXB9 HOXB9 CTNNB1 CTNNB1 SIX4 SIX4 SLC39A1 SLC39A1 COL2A1 COL2A1 HOXA4 HOXA4 DLX1 DLX1 PCSK5 PCSK5 EXT1 EXT1 GRHL2 GRHL2 RDH10 RDH10 EYA1 EYA1 GLI3 GLI3 HOXA11 HOXA11 HOXA5 HOXA5 HOXA2 HOXA2 HOXA1 HOXA1 TBXT TBXT MTHFD1L MTHFD1L MDFI MDFI EDNRA EDNRA WDR19 WDR19 HYAL1 HYAL1 SETD2 SETD2 TBX1 TBX1 BMP7 BMP7 SLC2A10 SLC2A10 IHH IHH HOXD10 HOXD10 DLX2 DLX2 ACVR2A ACVR2A SIX2 SIX2 OSR1 OSR1 FUZ FUZ MEGF8 MEGF8 MKS1 MKS1 NOG NOG COL1A1 COL1A1 HOXB6 HOXB6 HOXB5 HOXB5 HOXB4 HOXB4 HOXB2 HOXB2 HOXB1 HOXB1 PCGF2 PCGF2 XYLT1 XYLT1 IFT140 IFT140 GSC GSC TGFB3 TGFB3 MTHFD1 MTHFD1 BMP4 BMP4 MMP14 MMP14 FGF9 FGF9 ALX1 ALX1 MYF5 MYF5 HOXC6 HOXC6 HOXC9 HOXC9 HOXC11 HOXC11 DSCAML1 DSCAML1 WNT11 WNT11 FGFR2 FGFR2 NODAL NODAL UCMA UCMA WNT9A WNT9A FLVCR1 FLVCR1 PRRX1 PRRX1 ALX3 ALX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK20Cyclin-dependent kinase 20; Belongs to the protein kinase superfamily. (376 aa)
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
SHOX2SHOX2 isoform 2. (343 aa)
SOX11Transcription factor SOX. (441 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
HOXD1HOXD1 isoform 1. (328 aa)
HOXB8HOXB8 isoform 1. (243 aa)
WDR60WDR60 isoform 1. (943 aa)
HOXD4Homeobox protein Hox-D4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Deformed subfamily. (255 aa)
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
HOXD3HOXD3 isoform 3. (432 aa)
MBTD1Mbt domain containing 1. (630 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SP3Sp3 transcription factor. (781 aa)
MED12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifi [...] (2182 aa)
ENSPTRP00000085072annotation not available (320 aa)
ALX4ALX homeobox 4. (411 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ENSPTRP00000080279annotation not available (270 aa)
SATB2DNA-binding protein SATB. (733 aa)
HOXA1-2Homeobox A1. (335 aa)
HOXD9HOXD9 isoform 1. (356 aa)
ENSPTRP00000077262annotation not available (314 aa)
WNT9B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MMP16Matrix metallopeptidase 16 (Membrane-inserted). (609 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
HOXC4HOXC4 isoform 1. (264 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (901 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
HOXC5HOXC5 isoform 1. (222 aa)
DEAF1Deformed epidermal autoregulatory factor 1 homolog; Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expressio [...] (537 aa)
ENSPTRP00000071105annotation not available (376 aa)
HOXA3-2Homeobox A3. (443 aa)
SIX1SIX homeobox 1. (284 aa)
NKX3-2NKX3-2 isoform 1. (333 aa)
TULP3TULP3 isoform 3; Belongs to the TUB family. (501 aa)
HOXA3HOXA3 isoform 3. (443 aa)
IRX5Iroquois homeobox 5. (483 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
ENSPTRP00000066621annotation not available (709 aa)
HOXA6-2Homeobox A6. (233 aa)
DMRT2Doublesex and mab-3 related transcription factor 2. (561 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
MDFI-2MyoD family inhibitor. (246 aa)
TBX15T-box transcription factor 15. (602 aa)
EIF4A3Uncharacterized protein; Belongs to the DEAD box helicase family. (413 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
HOXB3HOXB3 isoform 13. (431 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PBX1Pre-B-cell leukemia homeobox 1. (486 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
HOXA6HOXA6 isoform 2. (233 aa)
TAPT1Transmembrane anterior posterior transformation 1. (664 aa)
KIAA1217KIAA1217 isoform 5. (1943 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
PAX5PAX5 isoform 1. (391 aa)
NIPBLNipped-B protein. (2804 aa)
TWIST1TWIST1 isoform 2. (163 aa)
NDST1N-deacetylase/N-sulfotransferase (Heparan glucosaminyl) 1. (882 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
SIX4SIX homeobox 4. (781 aa)
SLC39A1Solute carrier family 39 (Zinc transporter), member 1. (324 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
HOXA4HOXA4 isoform 1. (320 aa)
DLX1Distal-less homeobox 1. (255 aa)
PCSK5PCSK5 isoform 1; Belongs to the peptidase S8 family. (1860 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
RDH10Retinol dehydrogenase 10 (All-trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
HOXA11HOXA11 isoform 2. (313 aa)
HOXA5HOXA5 isoform 1. (270 aa)
HOXA2HOXA2 isoform 1. (376 aa)
HOXA1HOXA1 isoform 2. (335 aa)
TBXTT-box transcription factor T. (435 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like. (805 aa)
MDFIMyoD family inhibitor. (246 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
WDR19WD repeat domain 19. (1342 aa)
HYAL1Hyaluronidase. (435 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2564 aa)
TBX1TBX1 isoform 1. (478 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SLC2A10Solute carrier family 2 (Facilitated glucose transporter), member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
HOXD10Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa)
DLX2Distal-less homeobox 2. (328 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
SIX2SIX homeobox 2. (291 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
HOXB6HOXB6 isoform 1. (224 aa)
HOXB5HOXB5 isoform 1. (269 aa)
HOXB4HOXB4 isoform 1. (251 aa)
HOXB2HOXB2 isoform 1. (356 aa)
HOXB1Homeobox protein Hox-B1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures (By similarity); Belongs to the Antp homeobox family. Labial subfamily. (301 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
XYLT1Xylosyltransferase 1; Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D- xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal maturation of chondrocytes during bone development, normal onset of ossification and normal embryonic and postnatal skeleton development, especially of the long bones. (958 aa)
IFT140Intraflagellar transport 140 homolog. (1471 aa)
GSCHomeobox protein goosecoid; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity); Belongs to the paired homeobox family. Bicoid subfamily. (257 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MTHFD1MTHFD1 isoform 1. (1020 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ALX1ALX homeobox 1. (326 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
HOXC6HOXC6 isoform 1. (235 aa)
HOXC9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
HOXC11HOXC11 isoform 1. (304 aa)
DSCAML1DS cell adhesion molecule like 1. (2113 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
NODALNODAL isoform 2. (347 aa)
UCMAUCMA isoform 1. (138 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (569 aa)
PRRX1Paired related homeobox 1. (245 aa)
ALX3ALX homeobox 3. (343 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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