STRINGSTRING
RHEB RHEB DUSP10 DUSP10 CNTN2 CNTN2 MED12 MED12 HDAC11 HDAC11 HES5-2 HES5-2 CDK5 CDK5 OLIG1-2 OLIG1-2 ERCC2 ERCC2 ENSPTRP00000079007 ENSPTRP00000079007 ASCL1 ASCL1 NTRK2 NTRK2 LOC100611979 LOC100611979 HDAC1 HDAC1 SHH SHH TSPAN2 TSPAN2 CNTN1 CNTN1 NSUN5-2 NSUN5-2 LOC468384 LOC468384 ABCA2 ABCA2 NKX2-1 NKX2-1 OLIG1 OLIG1 LPAR1 LPAR1 EIF2B3 EIF2B3 PAX6 PAX6 LOC748850 LOC748850 PRDM8 PRDM8 CK820_G0042963 CK820_G0042963 OLIG2 OLIG2 ERBB2 ERBB2 ENSPTRP00000070165 ENSPTRP00000070165 ID4 ID4 MTOR MTOR CDKN2C CDKN2C SOX13 SOX13 BNIP3 BNIP3 NKX6-2 NKX6-2 MYRF MYRF ACY3 ACY3 TENM4 TENM4 EIF2B1 EIF2B1 EIF2B2 EIF2B2 CSK CSK SOX8 SOX8 FA2H FA2H ASPA ASPA NF1 NF1 SUZ12 SUZ12 CNP CNP SOX9 SOX9 B4GALT6 B4GALT6 TGFB1 TGFB1 EIF2B4 EIF2B4 MAL MAL GPR17 GPR17 DLX2 DLX2 NKX2-2 NKX2-2 B4GALT5 B4GALT5 EIF2B5 EIF2B5 NKX6-1 NKX6-1 GLI3 GLI3 NSUN5 NSUN5 CLU CLU NOTCH1 NOTCH1 PLP1 PLP1 DLX1 DLX1 WASF3 WASF3 HES5 HES5 SOX10 SOX10 SOX6 SOX6 CTNNB1 CTNNB1 TRPC4 TRPC4 LYN LYN NEUROD4 NEUROD4 LOC100614689 LOC100614689 CNTNAP1 CNTNAP1 CD22-2 CD22-2 PTPRZ1 PTPRZ1 ENSPTRP00000092184 ENSPTRP00000092184 NCSTN NCSTN ENSPTRP00000093022 ENSPTRP00000093022 NRG1 NRG1 TPPP TPPP SOX11 SOX11 PTEN PTEN SLC8A3 SLC8A3 ENSPTRP00000089750 ENSPTRP00000089750
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHEBRHEB isoform 1. (184 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (488 aa)
CNTN2CNTN2 isoform 13. (1040 aa)
MED12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifi [...] (2182 aa)
HDAC11HDAC11 isoform 14. (374 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
OLIG1-2OLIG1 isoform 1. (272 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
ENSPTRP00000079007annotation not available (323 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
LOC100611979Probable 28S rRNA (cytosine-C(5))-methyltransferase. (448 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
TSPAN2Tetraspanin. (228 aa)
CNTN1CNTN1 isoform 1. (1028 aa)
NSUN5-2NOP2/Sun domain family, member 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (466 aa)
LOC468384Polycomb protein SUZ12. (720 aa)
ABCA2ABCA2 isoform 8. (2364 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
OLIG1OLIG1 isoform 2. (272 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
EIF2B3Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa. (452 aa)
PAX6PAX6 isoform 13. (436 aa)
LOC748850HDAC2 isoform 9. (445 aa)
PRDM8PR domain containing 8. (1065 aa)
CK820_G0042963RHEB isoform 3. (182 aa)
OLIG2OLIG2 isoform 1. (323 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ENSPTRP00000070165annotation not available (67 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CDKN2CCyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4). (168 aa)
SOX13SRY (Sex determining region Y)-box 13. (622 aa)
BNIP3BCL2 interacting protein 3. (259 aa)
NKX6-2NKX6-2 isoform 1. (276 aa)
MYRFMYRF isoform 2. (932 aa)
ACY3Aspartoacylase (Aminocyclase) 3. (319 aa)
TENM4Teneurin transmembrane protein 4. (2769 aa)
EIF2B1Eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; Belongs to the eIF-2B alpha/beta/delta subunits family. (306 aa)
EIF2B2Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
CSKTyrosine-protein kinase. (450 aa)
SOX8SOX8 isoform 1. (446 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
ASPAAspartoacylase (Canavan disease). (313 aa)
NF1Neurofibromin 1. (2839 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (421 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
B4GALT6UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6. (382 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
EIF2B4Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa; Belongs to the eIF-2B alpha/beta/delta subunits family. (523 aa)
MALMal, T cell differentiation protein. (153 aa)
GPR17GPR17 isoform 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
DLX2Distal-less homeobox 2. (328 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
B4GALT5UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5. (388 aa)
EIF2B5Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa. (721 aa)
NKX6-1NKX6-1 isoform 2. (367 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
NSUN5NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (470 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
PLP1Proteolipid protein 1. (277 aa)
DLX1Distal-less homeobox 1. (255 aa)
WASF3WH2 domain-containing protein. (502 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
SOX10SRY-box transcription factor 10. (466 aa)
SOX6SOX6 isoform 9. (828 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
TRPC4Transient receptor potential cation channel, subfamily C, member 4; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
LYNTyrosine-protein kinase. (512 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
LOC100614689BCL2-related ovarian killer. (207 aa)
CNTNAP1Contactin associated protein 1. (1384 aa)
CD22-2B-cell receptor CD22. (626 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2315 aa)
ENSPTRP00000092184annotation not available (720 aa)
NCSTNNCSTN isoform 1. (721 aa)
ENSPTRP00000093022annotation not available (563 aa)
NRG1NRG1 isoform 3. (713 aa)
TPPPTubulin polymerization promoting protein. (219 aa)
SOX11Transcription factor SOX. (441 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
ENSPTRP00000089750annotation not available (448 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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