(25 nodes) Smooth muscle tissue development network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MYLK	MYLK isoform 12. (1919 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	ENSPTRP00000085289	annotation not available (322 aa)
	EFEMP2	EGF containing fibulin-like extracellular matrix protein 2. (443 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	COL3A1	Collagen type III alpha 1 chain. (1466 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (968 aa)
	SRF	Serum response factor (C-fos serum response element-binding transcription factor). (508 aa)
	SMO	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	ENG	ENG isoform 1. (658 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
	ZFAND5	Zinc finger AN1-type containing 5. (213 aa)
	SMO-2	Smoothened, frizzled class receptor. (786 aa)
	TIPARP	TIPARP isoform 1. (657 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	TFAP2B	Transcription factor AP-2 beta. (467 aa)
	STRA6	Stimulated by retinoic acid 6. (706 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	NF1	Neurofibromin 1. (2839 aa)
	ENSPTRP00000088772	annotation not available (192 aa)
	PTCH1	PTCH1 isoform 8. (1428 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	IHH	ENSPTRP00000010780	ENSPTRP00000022106	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.421
BMP4	PTCH1	ENSPTRP00000010780	ENSPTRP00000087586	Bone morphogenetic protein 4.	PTCH1 isoform 8.	0.454
BMP4	SHH	ENSPTRP00000010780	ENSPTRP00000075730	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.720
BMP4	SOX9	ENSPTRP00000010780	ENSPTRP00000016293	Bone morphogenetic protein 4.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.509
BMP4-2	IHH	ENSPTRP00000080656	ENSPTRP00000022106	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.421
BMP4-2	PTCH1	ENSPTRP00000080656	ENSPTRP00000087586	Bone morphogenetic protein 4.	PTCH1 isoform 8.	0.454
BMP4-2	SHH	ENSPTRP00000080656	ENSPTRP00000075730	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.720
BMP4-2	SOX9	ENSPTRP00000080656	ENSPTRP00000016293	Bone morphogenetic protein 4.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.509
COL3A1	EFEMP2	ENSPTRP00000021759	ENSPTRP00000006720	Collagen type III alpha 1 chain.	EGF containing fibulin-like extracellular matrix protein 2.	0.561
COL3A1	ENSPTRP00000085289	ENSPTRP00000021759	ENSPTRP00000085289	Collagen type III alpha 1 chain.	annotation not available	0.411
COL3A1	MYLK	ENSPTRP00000021759	ENSPTRP00000089511	Collagen type III alpha 1 chain.	MYLK isoform 12.	0.411
EFEMP2	COL3A1	ENSPTRP00000006720	ENSPTRP00000021759	EGF containing fibulin-like extracellular matrix protein 2.	Collagen type III alpha 1 chain.	0.561
ENG	SOX9	ENSPTRP00000036576	ENSPTRP00000016293	ENG isoform 1.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.472
ENSPTRP00000085289	COL3A1	ENSPTRP00000085289	ENSPTRP00000021759	annotation not available	Collagen type III alpha 1 chain.	0.411
IHH	BMP4	ENSPTRP00000022106	ENSPTRP00000010780	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 4.	0.421
IHH	BMP4-2	ENSPTRP00000022106	ENSPTRP00000080656	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 4.	0.421
IHH	PTCH1	ENSPTRP00000022106	ENSPTRP00000087586	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	PTCH1 isoform 8.	0.999
IHH	SHH	ENSPTRP00000022106	ENSPTRP00000075730	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.951
IHH	SMO	ENSPTRP00000022106	ENSPTRP00000033707	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.881
IHH	SMO-2	ENSPTRP00000022106	ENSPTRP00000067533	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Smoothened, frizzled class receptor.	0.880