STRINGSTRING
OVOL2 OVOL2 PEF1 PEF1 SEMA6C SEMA6C S100A4 S100A4 EFNA1 EFNA1 KLHL12 KLHL12 TGFB2 TGFB2 NRP1 NRP1 RET RET DLG5 DLG5 BMPR1A BMPR1A CYP26C1 CYP26C1 FGFR2 FGFR2 FGF19 FGF19 FOLR1 FOLR1 WNT11 WNT11 LRP6 LRP6 ALX1 ALX1 KITLG KITLG CORO1C CORO1C EDNRB EDNRB BMP4 BMP4 HIF1A HIF1A GSC GSC ALDH1A2 ALDH1A2 SEMA7A SEMA7A SEMA4B SEMA4B SOX8 SOX8 RFLNB RFLNB NOG NOG DDX5 DDX5 SOX9 SOX9 SMAD4 SMAD4 SEMA6B SEMA6B NRTN NRTN TGFB1 TGFB1 RPS7 RPS7 OSR1 OSR1 SIX2 SIX2 SEMA4C SEMA4C FRZB FRZB NRP2 NRP2 WNT10A WNT10A HTR2B HTR2B GBX2 GBX2 BMP2 BMP2 JAG1 JAG1 FAM83D FAM83D ZFP64 ZFP64 BMP7 BMP7 TBX1 TBX1 MAPK1 MAPK1 EOMES EOMES SEMA3G SEMA3G KBTBD8 KBTBD8 SEMA5B SEMA5B PHOX2B PHOX2B PITX2 PITX2 EDNRA EDNRA SEMA5A SEMA5A ISL1 ISL1 EDN1 EDN1 CUL7 CUL7 HEY2 HEY2 TCF21 TCF21 TBX20 TBX20 SEMA3C SEMA3C SEMA3A SEMA3A SEMA3D SEMA3D WNT2 WNT2 WNT16 WNT16 SMO SMO SNAI2 SNAI2 RDH10 RDH10 EXT1 EXT1 AKNA AKNA ENG ENG NOTCH1 NOTCH1 OTUD5 OTUD5 ADAM15 ADAM15 TASOR TASOR SOX10 SOX10 FN1 FN1 OLFM1 OLFM1 NOLC1 NOLC1 SEMA4F SEMA4F CTNNB1 CTNNB1 WWTR1 WWTR1 AMER1 AMER1 TWIST1 TWIST1 GDNF GDNF DACT3 DACT3 SEMA4D SEMA4D FOXF2 FOXF2 HAND2 HAND2 HMGA2 HMGA2 SFRP1 SFRP1 FOXC2 FOXC2 MAPK3 MAPK3 HNRNPAB HNRNPAB RTN4 RTN4 ENSPTRP00000055426 ENSPTRP00000055426 MSX1 MSX1 RADIL RADIL TAPT1 TAPT1 AMELX AMELX NOTCH4 NOTCH4 HAS2 HAS2 EPB41L5 EPB41L5 DDX17 DDX17 ERBB4 ERBB4 WNT4 WNT4 ROCK2 ROCK2 FLNA FLNA LOC735645 LOC735645 ENSPTRP00000063809 ENSPTRP00000063809 HES1 HES1 TRIM28 TRIM28 PHACTR4 PHACTR4 ENSPTRP00000064416 ENSPTRP00000064416 FOXC1 FOXC1 TGFBR3L TGFBR3L FGFR1 FGFR1 SEMA3E SEMA3E LOXL2 LOXL2 SNAI1 SNAI1 TGFBR3 TGFBR3 ENSPTRP00000066737 ENSPTRP00000066737 SEMA6A SEMA6A SMO-2 SMO-2 TCOF1 TCOF1 SEMA4A SEMA4A HEY1 HEY1 LOC459002 LOC459002 EDN3 EDN3 POLR1B POLR1B HGF HGF TGFBR1 TGFBR1 LOXL3 LOXL3 ENSPTRP00000074987 ENSPTRP00000074987 FGF8 FGF8 SHH SHH ACVR1 ACVR1 SEMA4G SEMA4G FAM172A FAM172A CDC42 CDC42 ENSPTRP00000078649 ENSPTRP00000078649 RBPJ RBPJ SEMA3F SEMA3F LEF1 LEF1 PDCD4 PDCD4 BMP4-2 BMP4-2 ANXA6 ANXA6 CITED2 CITED2 GSK3B GSK3B SEMA6D SEMA6D SPRY1 SPRY1 FBXL17 FBXL17 FGF10 FGF10 ENSPTRP00000083815 ENSPTRP00000083815 CK820_G0045089 CK820_G0045089 LOC104003681 LOC104003681 TBX3 TBX3 ROCK1 ROCK1 RANBP3L RANBP3L WNT5A WNT5A SEMA3B SEMA3B ENSPTRP00000086506 ENSPTRP00000086506 ENSPTRP00000087014 ENSPTRP00000087014 CDH2 CDH2 TMEM100 TMEM100 WNT8A WNT8A HEYL HEYL LAMA5 LAMA5 EFNB1 EFNB1 BCL2 BCL2 MEF2C MEF2C SOX11 SOX11 STAT1 STAT1 PAX2 PAX2 ENSPTRP00000091667 ENSPTRP00000091667 NRG1 NRG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OVOL2Ovo like zinc finger 2. (275 aa)
PEF1Penta-EF-hand domain containing 1. (284 aa)
SEMA6CSEMA6C isoform 2; Belongs to the semaphorin family. (962 aa)
S100A4Protein S100; Belongs to the S-100 family. (101 aa)
EFNA1EFNA1 isoform 2; Belongs to the ephrin family. (205 aa)
KLHL12Kelch like family member 12. (568 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FOLR1Folate receptor alpha. (257 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
ALX1ALX homeobox 1. (326 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (527 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
GSCHomeobox protein goosecoid; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity); Belongs to the paired homeobox family. Bicoid subfamily. (257 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
SEMA7ASEMA7A isoform 1; Belongs to the semaphorin family. (664 aa)
SEMA4BSEMA4B isoform 1; Belongs to the semaphorin family. (836 aa)
SOX8SOX8 isoform 1. (446 aa)
RFLNBRFLNB isoform 1. (144 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SEMA6BSema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6B; Belongs to the semaphorin family. (888 aa)
NRTNNRTN isoform 1. (197 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
SIX2SIX homeobox 2. (291 aa)
SEMA4CSEMA4C isoform 2; Belongs to the semaphorin family. (833 aa)
FRZBFrizzled-related protein. (325 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
FAM83DFAM83D isoform 1. (613 aa)
ZFP64Zinc finger protein 64 homolog. (681 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TBX1TBX1 isoform 1. (478 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
EOMESEOMES isoform 2. (704 aa)
SEMA3GSEMA3G isoform 2; Belongs to the semaphorin family. (782 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
SEMA5BSEMA5B isoform 1. (1352 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
PITX2Homeobox protein. (324 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SEMA5ASEMA5A isoform 1. (1074 aa)
ISL1ISL LIM homeobox 1. (349 aa)
EDN1EDN1 isoform 1. (212 aa)
CUL7CUL7 isoform 2; Belongs to the cullin family. (1782 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
TCF21Transcription factor 21. (179 aa)
TBX20T-box transcription factor 20. (447 aa)
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
SEMA3ASEMA3A isoform 1; Belongs to the semaphorin family. (771 aa)
SEMA3DSEMA3D isoform 1; Belongs to the semaphorin family. (777 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
RDH10Retinol dehydrogenase 10 (All-trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
AKNAAT-hook transcription factor. (1440 aa)
ENGENG isoform 1. (658 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
OTUD5OTU deubiquitinase 5. (598 aa)
ADAM15ADAM metallopeptidase domain 15. (863 aa)
TASORTranscription activation suppressor. (1609 aa)
SOX10SRY-box transcription factor 10. (466 aa)
FN1FN1 isoform 1. (2477 aa)
OLFM1OLFM1 isoform 3. (485 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (701 aa)
SEMA4FSEMA4F isoform 1; Belongs to the semaphorin family. (770 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
AMER1APC membrane recruitment protein 1. (805 aa)
TWIST1TWIST1 isoform 2. (163 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
DACT3Dishevelled binding antagonist of beta catenin 3. (181 aa)
SEMA4DSEMA4D isoform 13; Belongs to the semaphorin family. (862 aa)
FOXF2FOXF2 isoform 1. (444 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
HNRNPABHeterogeneous nuclear ribonucleoprotein A/B. (332 aa)
RTN4Reticulon. (1192 aa)
ENSPTRP00000055426annotation not available (200 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
RADILRap associating with DIL domain. (1075 aa)
TAPT1Transmembrane anterior posterior transformation 1. (664 aa)
AMELXAmelogenin X-linked. (205 aa)
NOTCH4NOTCH4 isoform 3. (2006 aa)
HAS2Hyaluronan synthase 2. (554 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (735 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
FLNAFLNA isoform 8. (2711 aa)
LOC73564540S ribosomal protein S7 pseudogene. (177 aa)
ENSPTRP00000063809annotation not available (177 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
TRIM28Tripartite motif containing 28. (835 aa)
PHACTR4Phosphatase and actin regulator. (712 aa)
ENSPTRP00000064416annotation not available (502 aa)
FOXC1FOXC1 isoform 1. (550 aa)
TGFBR3LTGFBR3L isoform 1. (313 aa)
FGFR1Fibroblast growth factor receptor. (854 aa)
SEMA3ESEMA3E isoform 1; Belongs to the semaphorin family. (775 aa)
LOXL2LOXL2 isoform 4. (744 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
ENSPTRP00000066737annotation not available (186 aa)
SEMA6ASEMA6A isoform 2; Belongs to the semaphorin family. (1047 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
TCOF1TCOF1 isoform 1. (1525 aa)
SEMA4ASEMA4A isoform 10; Belongs to the semaphorin family. (761 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
LOC45900240S ribosomal protein S7 pseudogene. (189 aa)
EDN3EDN3 isoform 1. (238 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1135 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
LOXL3Lysyl oxidase-like 3. (753 aa)
ENSPTRP00000074987annotation not available (189 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
SEMA4GSEMA4G isoform 3; Belongs to the semaphorin family. (843 aa)
FAM172AFamily with sequence similarity 172, member A. (433 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
ENSPTRP00000078649annotation not available (188 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
SEMA3FSEMA3F isoform 2; Belongs to the semaphorin family. (785 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
PDCD4Programmed cell death 4 (Neoplastic transformation inhibitor). (469 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ANXA6Annexin. (788 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
SEMA6DSema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6D; Belongs to the semaphorin family. (1086 aa)
SPRY1Sprouty homolog 1, antagonist of FGF signaling. (319 aa)
FBXL17F-box and leucine rich repeat protein 17. (715 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSPTRP00000083815annotation not available (125 aa)
CK820_G0045089RANBP3 isoform 23. (97 aa)
LOC104003681Kelch-like protein 12 pseudogene. (535 aa)
TBX3T-box transcription factor 3. (743 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
RANBP3LRAN binding protein 3 like. (490 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SEMA3BSEMA3B isoform 2; Belongs to the semaphorin family. (749 aa)
ENSPTRP00000086506annotation not available (250 aa)
ENSPTRP00000087014annotation not available (777 aa)
CDH2Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
TMEM100Transmembrane protein 100. (134 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
LAMA5Laminin, alpha 5. (2203 aa)
EFNB1EFNB1 isoform 1; Belongs to the ephrin family. (346 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SOX11Transcription factor SOX. (441 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
PAX2PAX2 isoform 1. (417 aa)
ENSPTRP00000091667annotation not available (191 aa)
NRG1NRG1 isoform 3. (713 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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