STRINGSTRING
CCR2 CCR2 LIF LIF LRP5L LRP5L CBS CBS GDF5 GDF5 JAG1 JAG1 RASSF2 RASSF2 IHH IHH IGFBP5 IGFBP5 IL1A IL1A CK820_G0041206 CK820_G0041206 EPAS1 EPAS1 TGFB1 TGFB1 ACP5 ACP5 RAB3D RAB3D P3H4 P3H4 TGFB3 TGFB3 HIF1A HIF1A MMP14 MMP14 TNFSF11 TNFSF11 IL23A IL23A ACVRL1 ACVRL1 CELA1 CELA1 IAPP IAPP BSX BSX TCIRG1 TCIRG1 LTBP3 LTBP3 TRAF6 TRAF6 PTH PTH TPP1 TPP1 LIPA LIPA TIE1 TIE1 EPHA2 EPHA2 AXL AXL MMP2 MMP2 ENSPTRP00000088770 ENSPTRP00000088770 MEF2C MEF2C CTSK CTSK LRRK1 LRRK1 ENSPTRP00000092702 ENSPTRP00000092702 BAX BAX LGR4 LGR4 ARG1 ARG1 PLG PLG SNX10 SNX10 SEMA3C SEMA3C CAV1 CAV1 WNT16 WNT16 NOS3 NOS3 PTK2B PTK2B CHD7 CHD7 CTHRC1 CTHRC1 EXT1 EXT1 DBH DBH CCDC154 CCDC154 CTNNB1 CTNNB1 NCDN NCDN ZNF675 ZNF675 CRB1 CRB1 NOX4 NOX4 BMPR2 BMPR2 EFNA2 EFNA2 BAK1 BAK1 FOXC2 FOXC2 FLNA FLNA ATP7A ATP7A FOXC1 FOXC1 ENSPTRP00000065244 ENSPTRP00000065244 LOC736481 LOC736481 CSPG4 CSPG4 HOXA3 HOXA3 CAPN1 CAPN1 LRP5 LRP5 DLL4 DLL4 HOXA3-2 HOXA3-2 ENSPTRP00000071463 ENSPTRP00000071463 SPP2 SPP2 LOC745271 LOC745271 AGTR2 AGTR2 NOL3 NOL3 FGF8 FGF8 NOTCH2 NOTCH2 ENSPTRP00000076674 ENSPTRP00000076674 SRC SRC UMOD UMOD ACVR2B ACVR2B ELF3 ELF3 TPH1 TPH1 ENSPTRP00000078515 ENSPTRP00000078515 IL7 IL7 RBPJ RBPJ PTN PTN TIMP1 TIMP1 FGF10 FGF10 VDR VDR HNF1A HNF1A MITF MITF RSPO3 RSPO3 ATG5 ATG5 HTR1B HTR1B ADRB2 ADRB2 THBS4 THBS4 F2R F2R EDNRA EDNRA NFKB1 NFKB1 PTH1R PTH1R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
LRP5LLDL receptor related protein 5 like. (252 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
GDF5GDF5 isoform 1. (501 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
RASSF2Ras association (RalGDS/AF-6) domain family member 2. (326 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
CK820_G0041206PLGLB1 isoform 2. (104 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
RAB3DRAB3D, member RAS oncogene family. (219 aa)
P3H4P3H4 isoform 2. (443 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
CELA1CELA1 isoform 1; Belongs to the peptidase S1 family. (258 aa)
IAPPIslet amyloid polypeptide. (89 aa)
BSXBrain specific homeobox. (233 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
TPP1Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). (563 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
EPHA2EPH receptor A2. (976 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
ENSPTRP00000088770annotation not available (124 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
CTSKCTSK isoform 2; Belongs to the peptidase C1 family. (343 aa)
LRRK1Leucine-rich repeat kinase 1. (2015 aa)
ENSPTRP00000092702annotation not available (482 aa)
BAXBAX isoform 7. (123 aa)
LGR4LGR4 isoform 2. (951 aa)
ARG1Arginase. (322 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
SNX10Sorting nexin 10. (201 aa)
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CHD7CHD7 isoform 1. (2997 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
DBHDopamine beta-hydroxylase. (617 aa)
CCDC154Coiled-coil domain containing 154. (522 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
NCDNNCDN isoform 2. (729 aa)
ZNF675ZNF675 isoform 4. (568 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
NOX4NADPH oxidase 4. (578 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
EFNA2EFNA2 isoform 1; Belongs to the ephrin family. (190 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
FLNAFLNA isoform 8. (2711 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
FOXC1FOXC1 isoform 1. (550 aa)
ENSPTRP00000065244annotation not available (463 aa)
LOC736481Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (400 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2421 aa)
HOXA3HOXA3 isoform 3. (443 aa)
CAPN1Calpain 1, (Mu/I) large subunit; Belongs to the peptidase C2 family. (733 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
HOXA3-2Homeobox A3. (443 aa)
ENSPTRP00000071463LOW QUALITY PROTEIN: chondroitin sulfate proteoglycan 4. (205 aa)
SPP2Secreted phosphoprotein 2. (245 aa)
LOC745271PLGLB1 isoform 1. (150 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
NOL3Nucleolar protein 3. (219 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
ENSPTRP00000076674annotation not available (245 aa)
SRCTyrosine-protein kinase. (542 aa)
UMODUMOD isoform 1. (690 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
ELF3E74 like ETS transcription factor 3. (375 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
ENSPTRP00000078515annotation not available (198 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (179 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
PTNPTN isoform 2. (172 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
VDRVitamin D (1,25-dihydroxyvitamin D3) receptor. (477 aa)
HNF1AHNF1 homeobox A. (662 aa)
MITFMITF isoform 1. (519 aa)
RSPO3RSPO3 isoform 1. (292 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
HTR1B5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (390 aa)
ADRB2Adrenergic, beta-2-, receptor, surface. (429 aa)
THBS4THBS4 isoform 3. (961 aa)
F2RCoagulation factor II (Thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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