(40 nodes) Brain morphogenesis network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	GSX2	GSX2 isoform 2. (304 aa)
	ENSPTRP00000093022	annotation not available (563 aa)
	CDH2	Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
	PAX2	PAX2 isoform 1. (417 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	ENSPTRP00000090750	annotation not available (278 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	UCHL5	Ubiquitin carboxyl-terminal hydrolase. (393 aa)
	VPS51	Chromosome 11 open reading frame 2. (788 aa)
	SLIT1	Slit guidance ligand 1. (1534 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
	FBXW11	F-box and WD repeat domain containing 11. (563 aa)
	SLC4A10	Anion exchange protein. (1138 aa)
	CTNNA2	CTNNA2 isoform 11. (953 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	SMO-2	Smoothened, frizzled class receptor. (786 aa)
	SPEF2	SPEF2 isoform 4. (2168 aa)
	SHANK3	SHANK3 isoform 2. (1744 aa)
	ENSPTRP00000063424	annotation not available (1563 aa)
	ENSPTRP00000061796	annotation not available (123 aa)
	EMX1	Empty spiracles homeobox 1. (290 aa)
	BBS4	Bardet-Biedl syndrome 4. (519 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	FZD6	Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
	FANCC	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	SMO	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	CTNNA1	CTNNA1 isoform 21. (906 aa)
	HESX1	Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). (185 aa)
	FANCD2	FANCD2 isoform 1. (1417 aa)
	ZNF335	Zinc finger protein 335. (1342 aa)
	MKKS	McKusick-Kaufman syndrome. (570 aa)
	OTX1	Orthodenticle homeobox 1. (354 aa)
	NF1	Neurofibromin 1. (2839 aa)
	SLC6A4	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (721 aa)
	DUOX2	DUOX2 isoform 1. (1548 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	BBS1	Bardet-Biedl syndrome 1 protein isoform X1. (593 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT3	ENSPTRP00000093022	ENSPTRP00000086046	ENSPTRP00000093022	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	annotation not available	0.622
AKT3	PTEN	ENSPTRP00000086046	ENSPTRP00000090779	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.710
BBS1	BBS2	ENSPTRP00000006768	ENSPTRP00000013880	Bardet-Biedl syndrome 1 protein isoform X1.	Bardet-Biedl syndrome 2 protein homolog.	0.999
BBS1	BBS4	ENSPTRP00000006768	ENSPTRP00000057396	Bardet-Biedl syndrome 1 protein isoform X1.	Bardet-Biedl syndrome 4.	0.999
BBS1	MKKS	ENSPTRP00000006768	ENSPTRP00000022725	Bardet-Biedl syndrome 1 protein isoform X1.	McKusick-Kaufman syndrome.	0.421
BBS1	SMO	ENSPTRP00000006768	ENSPTRP00000033707	Bardet-Biedl syndrome 1 protein isoform X1.	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.689
BBS1	SMO-2	ENSPTRP00000006768	ENSPTRP00000067533	Bardet-Biedl syndrome 1 protein isoform X1.	Smoothened, frizzled class receptor.	0.689
BBS2	BBS1	ENSPTRP00000013880	ENSPTRP00000006768	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 1 protein isoform X1.	0.999
BBS2	BBS4	ENSPTRP00000013880	ENSPTRP00000057396	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 4.	0.999
BBS2	MKKS	ENSPTRP00000013880	ENSPTRP00000022725	Bardet-Biedl syndrome 2 protein homolog.	McKusick-Kaufman syndrome.	0.527
BBS2	SMO	ENSPTRP00000013880	ENSPTRP00000033707	Bardet-Biedl syndrome 2 protein homolog.	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.545
BBS2	SMO-2	ENSPTRP00000013880	ENSPTRP00000067533	Bardet-Biedl syndrome 2 protein homolog.	Smoothened, frizzled class receptor.	0.545
BBS4	BBS1	ENSPTRP00000057396	ENSPTRP00000006768	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 1 protein isoform X1.	0.999
BBS4	BBS2	ENSPTRP00000057396	ENSPTRP00000013880	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 2 protein homolog.	0.999
BBS4	SMO	ENSPTRP00000057396	ENSPTRP00000033707	Bardet-Biedl syndrome 4.	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.545
BBS4	SMO-2	ENSPTRP00000057396	ENSPTRP00000067533	Bardet-Biedl syndrome 4.	Smoothened, frizzled class receptor.	0.545
CDH2	CTNNA1	ENSPTRP00000092804	ENSPTRP00000029566	Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins.	CTNNA1 isoform 21.	0.966
CDH2	CTNNA2	ENSPTRP00000092804	ENSPTRP00000075894	Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins.	CTNNA2 isoform 11.	0.935
CDH2	ENSPTRP00000093022	ENSPTRP00000092804	ENSPTRP00000093022	Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins.	annotation not available	0.492
CDH2	FGF8	ENSPTRP00000092804	ENSPTRP00000075677	Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.727