35 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BCL2	BCL2 apoptosis regulator. (239 aa)
	ILDR2	Immunoglobulin like domain containing receptor 2. (639 aa)
	BAX	BAX isoform 7. (123 aa)
	ENSPTRP00000092364	annotation not available (574 aa)
	FH	Fumarate hydratase. (510 aa)
	LIPA	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	PRDX5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (214 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	KLHL10	Kelch like family member 10. (608 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	LRRC45	Leucine rich repeat containing 45. (670 aa)
	RAC3	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3). (205 aa)
	IL20RB	Interleukin 20 receptor subunit beta. (311 aa)
	F2R	Coagulation factor II (Thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
	SMO	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	SASH3	SAM and SH3 domain containing 3. (380 aa)
	VPS54	Vacuolar protein sorting 54 homolog. (977 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	GATA2	GATA binding protein 2. (480 aa)
	CK820_G0015936	C12orf76 isoform 1. (107 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	ENSPTRP00000067174	annotation not available (502 aa)
	SMO-2	Smoothened, frizzled class receptor. (786 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
	PTPN11-2	Protein tyrosine phosphatase non-receptor type 11. (579 aa)
	ENSPTRP00000074763	annotation not available (520 aa)
	ENSPTRP00000077211	annotation not available (269 aa)
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (179 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PRDM14	PR/SET domain 14. (571 aa)
	GATA1	GATA binding protein 1. (413 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT3	BCL2	ENSPTRP00000086046	ENSPTRP00000090293	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 apoptosis regulator.	0.934
AKT3	KRAS	ENSPTRP00000086046	ENSPTRP00000084588	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.530
AKT3	NOS3	ENSPTRP00000086046	ENSPTRP00000034022	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.567
AKT3	NOTCH1	ENSPTRP00000086046	ENSPTRP00000036924	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	NOTCH1 isoform 1.	0.495
BAX	BCL2	ENSPTRP00000092787	ENSPTRP00000090293	BAX isoform 7.	BCL2 apoptosis regulator.	0.971
BCL2	AKT3	ENSPTRP00000090293	ENSPTRP00000086046	BCL2 apoptosis regulator.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.934
BCL2	BAX	ENSPTRP00000090293	ENSPTRP00000092787	BCL2 apoptosis regulator.	BAX isoform 7.	0.971
BCL2	IL7	ENSPTRP00000090293	ENSPTRP00000079272	BCL2 apoptosis regulator.	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	0.607
BCL2	KRAS	ENSPTRP00000090293	ENSPTRP00000084588	BCL2 apoptosis regulator.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.773
BCL2	NOS3	ENSPTRP00000090293	ENSPTRP00000034022	BCL2 apoptosis regulator.	Nitric oxide synthase; Produces nitric oxide (NO).	0.462
BCL2	NOTCH1	ENSPTRP00000090293	ENSPTRP00000036924	BCL2 apoptosis regulator.	NOTCH1 isoform 1.	0.569
CSF1	IL7	ENSPTRP00000070067	ENSPTRP00000079272	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	0.543
ENSPTRP00000067174	KRAS	ENSPTRP00000067174	ENSPTRP00000084588	annotation not available	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.659
ENSPTRP00000074763	KRAS	ENSPTRP00000074763	ENSPTRP00000084588	annotation not available	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.601
ENSPTRP00000077211	KRAS	ENSPTRP00000077211	ENSPTRP00000084588	annotation not available	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.601
ENSPTRP00000092364	KRAS	ENSPTRP00000092364	ENSPTRP00000084588	annotation not available	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.601
GATA1	GATA2	ENSPTRP00000086593	ENSPTRP00000054198	GATA binding protein 1.	GATA binding protein 2.	0.855
GATA1	PRDM14	ENSPTRP00000086593	ENSPTRP00000086310	GATA binding protein 1.	PR/SET domain 14.	0.422
GATA2	GATA1	ENSPTRP00000054198	ENSPTRP00000086593	GATA binding protein 2.	GATA binding protein 1.	0.855
GATA2	KRAS	ENSPTRP00000054198	ENSPTRP00000084588	GATA binding protein 2.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.513