STRINGSTRING
SOX11 SOX11 PDCD1LG2 PDCD1LG2 ENSPTRP00000093022 ENSPTRP00000093022 SCRIB-2 SCRIB-2 TNFRSF14 TNFRSF14 PLA2G2D PLA2G2D PLA2G2F PLA2G2F GLMN GLMN ZBTB7B ZBTB7B RC3H1 RC3H1 IL10 IL10 IL2RA IL2RA DLG5 DLG5 SCGB1A1 SCGB1A1 GAL GAL PAWR PAWR BMP4 BMP4 ARG2 ARG2 TNFRSF13B TNFRSF13B FOXJ1 FOXJ1 TWSG1 TWSG1 CLEC4G CLEC4G TYROBP TYROBP TGFB1 TGFB1 LILRB1 LILRB1 IHH IHH INPP5D INPP5D CBLB CBLB CD80 CD80 CD86 CD86 IL20RB IL20RB IL2 IL2 TMEM131L TMEM131L NDFIP1 NDFIP1 HAVCR2 HAVCR2 TNFRSF21 TNFRSF21 LRRC1 LRRC1 ARG1 ARG1 IDO1 IDO1 CD274 CD274 FOXP3 FOXP3 VSIG4 VSIG4 BTK BTK CD300A CD300A PELI1 PELI1 VSIR VSIR ITCH ITCH ENSPTRP00000043137 ENSPTRP00000043137 PDE5A PDE5A PRKAR1A PRKAR1A LYN LYN CRTAM CRTAM BLK BLK PTPN6 PTPN6 RASSF5 RASSF5 SPN SPN ATM ATM CASP3 CASP3 IL4I1 IL4I1 PATR-G PATR-G MAD1L1 MAD1L1 SCRIB SCRIB BTN2A2 BTN2A2 MARCHF7 MARCHF7 VTCN1 VTCN1 DLG1 DLG1 SPN-2 SPN-2 LST1 LST1 LRRC32 LRRC32 ENSPTRP00000068326 ENSPTRP00000068326 TSPAN32 TSPAN32 ERBB2 ERBB2 CK820_G0030371 CK820_G0030371 LILRB4 LILRB4 ENSPTRP00000072507 ENSPTRP00000072507 PRNP PRNP SHH SHH CDKN2A CDKN2A SFTPD SFTPD PKN1 PKN1 CTLA4 CTLA4 BMP4-2 BMP4-2 CK820_G0028374 CK820_G0028374 SDC4 SDC4 CEBPB CEBPB GPNMB GPNMB LGALS9 LGALS9 MNDA MNDA PTEN PTEN ICOSLG ICOSLG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX11Transcription factor SOX. (441 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (288 aa)
ENSPTRP00000093022annotation not available (563 aa)
SCRIB-2Scribbled homolog. (1662 aa)
TNFRSF14Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator). (283 aa)
PLA2G2DPhospholipase A(2). (161 aa)
PLA2G2FPhospholipase A(2). (211 aa)
GLMNGlomulin, FKBP associated protein. (594 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
RC3H1Ring finger and CCCH-type domains 1. (1134 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (272 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)
SCGB1A1Secretoglobin family 1A member 1. (91 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
PAWRPRKC, apoptosis, WT1, regulator. (340 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ARG2Arginase. (354 aa)
TNFRSF13BTNF receptor superfamily member 13B. (293 aa)
FOXJ1FOXJ1 isoform 1. (421 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
TYROBPTYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (144 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LILRB1LILRB1 isoform 3. (697 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
CBLBCas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa)
CD80CD80 isoform 1. (288 aa)
CD86CD86 isoform 3. (329 aa)
IL20RBInterleukin 20 receptor subunit beta. (311 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
TMEM131LTMEM131L isoform 3. (1617 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (301 aa)
TNFRSF21TNFRSF21 isoform 1. (655 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
ARG1Arginase. (322 aa)
IDO1IDO1 isoform 2. (403 aa)
CD274CD274 isoform 2. (290 aa)
FOXP3FOXP3 isoform 4. (456 aa)
VSIG4V-set and immunoglobulin domain containing 4. (399 aa)
BTKBTK isoform 2. (693 aa)
CD300ACD300A isoform 1. (299 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
VSIRChromosome 10 open reading frame 54. (311 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
ENSPTRP00000043137Galectin-1. (130 aa)
PDE5APhosphodiesterase. (875 aa)
PRKAR1AProtein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1). (381 aa)
LYNTyrosine-protein kinase. (512 aa)
CRTAMCytotoxic and regulatory T cell molecule. (393 aa)
BLKTyrosine-protein kinase. (505 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
RASSF5Ras association (RalGDS/AF-6) domain family member 5. (418 aa)
SPNSPN isoform 3. (400 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
IL4I1Amine oxidase. (589 aa)
PATR-GPatr class I histocompatibility antigen, alpha chain G; Involved in the presentation of foreign antigens to the immune system. (371 aa)
MAD1L1MAD1 mitotic arrest deficient-like 1. (718 aa)
SCRIBSCRIB isoform 8. (959 aa)
BTN2A2Butyrophilin subfamily 2 member A2. (532 aa)
MARCHF7MARCH7 isoform 6. (666 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (285 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
SPN-2SPN isoform 1. (418 aa)
LST1Leukocyte specific transcript 1. (104 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
ENSPTRP00000068326annotation not available (488 aa)
TSPAN32TSPAN32 isoform 3; Belongs to the tetraspanin (TM4SF) family. (320 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
CK820_G0030371Galectin. (135 aa)
LILRB4LILRB4 isoform 7. (449 aa)
ENSPTRP00000072507annotation not available (659 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (253 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
SFTPDSurfactant protein D. (375 aa)
PKN1PKN1 isoform 2. (948 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
CK820_G0028374Galectin. (343 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
GPNMBGPNMB isoform 2. (574 aa)
LGALS9Galectin. (355 aa)
MNDAMyeloid cell nuclear differentiation antigen. (407 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ICOSLGICOSLG isoform 3. (590 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.