Your Input: | |
| | CAV2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa) |
| | WDR77 | Methylosome protein 50. (342 aa) |
| | CD34 | CD34 isoform 1. (328 aa) |
| | HLX | H2.0-like homeobox. (493 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | LIPA | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (841 aa) |
| | MKI67 | MKI67 isoform 1. (3257 aa) |
| | COL8A1 | Collagen type VIII alpha 1 chain. (744 aa) |
| | SFN | SFN isoform 1; Belongs to the 14-3-3 family. (248 aa) |
| | KRT2 | KRT2 isoform 1; Belongs to the intermediate filament family. (645 aa) |
| | FOXE3 | FOXE3 isoform 1. (319 aa) |
| | IQGAP3 | IQ motif containing GTPase activating protein 3. (1589 aa) |
| | NOX5 | NADPH oxidase 5. (737 aa) |
| | PROX1 | Prospero homeobox 1. (737 aa) |
| | BAK1 | BCL2-antagonist/killer 1. (211 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa) |
| | BAD | Bcl2-associated agonist of cell death. (168 aa) |
| | LGR4 | LGR4 isoform 2. (951 aa) |
| | NCSTN | NCSTN isoform 1. (721 aa) |
| | FABP7 | Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (166 aa) |
| | BAX | BAX isoform 7. (123 aa) |
| | IRF6 | Interferon regulatory factor 6. (467 aa) |
| | PHB2 | Prohibitin. (299 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (744 aa) |
| | ST8SIA1 | Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. (356 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (483 aa) |
| | MTA3 | Metastasis associated 1 family member 3. (594 aa) |
| | ENSPTRP00000088518 | annotation not available (428 aa) |
| | FERMT1 | Fermitin family member 1. (677 aa) |
| | PTCH1 | PTCH1 isoform 8. (1428 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | CCND1 | CCND1 isoform 1; Belongs to the cyclin family. (295 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (347 aa) |
| | BTBD10 | BTB (POZ) domain containing 10. (475 aa) |
| | LIMS2 | LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (365 aa) |
| | SDR16C5 | SDR16C5 isoform 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (328 aa) |
| | HMX2 | H6 family homeobox 2. (273 aa) |
| | ENSPTRP00000084126 | annotation not available (117 aa) |
| | MTSS1 | MTSS I-BAR domain containing 1. (759 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | IFT74 | Intraflagellar transport 74 homolog. (600 aa) |
| | CCN3 | NOV isoform 1. (357 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa) |
| | THAP1 | THAP domain containing, apoptosis associated protein 1. (213 aa) |
| | NKX2-6 | NKX2-6 isoform 1. (301 aa) |
| | FGL1 | Fibrinogen like 1. (312 aa) |
| | TRIM24 | Tripartite motif containing 24. (1054 aa) |
| | SMO | SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | WNT2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | IGFBP3 | Insulin like growth factor binding protein 3. (291 aa) |
| | BMPER | BMP binding endothelial regulator. (685 aa) |
| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa) |
| | SERPINB1 | Serpin peptidase inhibitor, clade B (Ovalbumin), member 1; Belongs to the serpin family. (379 aa) |
| | NKX2-5 | NKX2-5 isoform 1. (325 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | FST | FST isoform 1. (344 aa) |
| | SEMA5A | SEMA5A isoform 1. (1074 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa) |
| | NKX6-1 | NKX6-1 isoform 2. (367 aa) |
| | EREG | EREG isoform 1. (169 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa) |
| | KIT | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa) |
| | PHOX2B | Paired like homeobox 2B. (314 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | IFT80 | Intraflagellar transport protein 80 homolog. (763 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa) |
| | A4GNT | Alpha-1,4-N-acetylglucosaminyltransferase. (340 aa) |
| | RETNLB | Resistin like beta. (111 aa) |
| | IFT57 | Intraflagellar transport 57 homolog. (429 aa) |
| | HMOX1 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | IFT52 | Intraflagellar transport 52 homolog. (437 aa) |
| | BCL2L1 | BCL2L1 isoform 6. (233 aa) |
| | IGFBP5 | Insulin-like growth factor-binding protein 5. (272 aa) |
| | FAP | Fibroblast activation protein, alpha; Belongs to the peptidase S9B family. (760 aa) |
| | ACVR2A | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa) |
| | FSHR | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa) |
| | ID2 | Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa) |
| | KLK8 | Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (260 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa) |
| | SOX9 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa) |
| | TBX2 | T-box transcription factor 2. (712 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | IGFBP4 | Insulin like growth factor binding protein 4. (258 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa) |
| | NF1 | Neurofibromin 1. (2839 aa) |
| | SERPINF1 | SERPINF1 isoform 1; Belongs to the serpin family. (418 aa) |
| | CDH13 | CDH13 isoform 2. (760 aa) |
| | ESRP2 | Epithelial splicing regulatory protein 2. (717 aa) |
| | HSF4 | Heat shock transcription factor 4. (498 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa) |
| | BMP4 | Bone morphogenetic protein 4. (408 aa) |
| | SAV1 | Salvador family WW domain containing protein 1. (384 aa) |
| | NKX2-8 | NKX2-8 isoform 1. (239 aa) |
| | MMP14 | Matrix metallopeptidase 14. (582 aa) |
| | IRS2 | IRS2 isoform 1. (1340 aa) |
| | EFNB2 | EFNB2 isoform 1; Belongs to the ephrin family. (333 aa) |
| | DACH1 | DACH1 isoform 4. (761 aa) |
| | RB1 | RB transcriptional corepressor 1. (928 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member. (317 aa) |
| | PDX1 | Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | ACVRL1 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa) |
| | CLEC12B | CLEC12B isoform 1. (275 aa) |
| | SIDT2 | SID1 transmembrane family member 2 isoform X7. (854 aa) |
| | YAP1 | Yes-associated protein 1. (508 aa) |
| | OVOL1 | Ovo like transcriptional repressor 1. (267 aa) |
| | FSHB | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa) |
| | ITGB1BP1 | Integrin subunit beta 1 binding protein 1. (200 aa) |
| | EHF | ETS homologous factor; Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity). (322 aa) |
| | C6H6orf89 | Chromosome 6 open reading frame 89. (356 aa) |
| | NKX3-1 | NKX3-1 isoform 1. (234 aa) |
| | STK3 | Serine/threonine kinase 3. (519 aa) |
| | BMP4-2 | Bone morphogenetic protein 4. (408 aa) |
| | TRIM24-2 | Tripartite motif containing 24. (1050 aa) |
| | IL6-2 | Interleukin 6. (234 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (977 aa) |
| | LGR5 | Leucine rich repeat containing G protein-coupled receptor 5. (907 aa) |
| | SCARB1 | SCARB1 isoform 8; Belongs to the CD36 family. (552 aa) |
| | RBPJ | Recombination signal binding protein for immunoglobulin kappa J region. (500 aa) |
| | TGFA | TGFA isoform 6. (193 aa) |
| | ENSPTRP00000078515 | annotation not available (198 aa) |
| | RASGRF1 | Ras protein specific guanine nucleotide releasing factor 1. (1273 aa) |
| | AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa) |
| | AR | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa) |
| | NOTCH2 | NOTCH2 isoform 1. (2612 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa) |
| | FLCN | T0180863 isoform 1. (579 aa) |
| | CD109 | CD109 isoform 3. (1446 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa) |
| | HGF | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa) |
| | PROK2 | PROK2 isoform 2. (129 aa) |
| | EAF2 | ELL associated factor 2. (263 aa) |
| | IFT172 | Intraflagellar transport 172 homolog. (1767 aa) |
| | TEK | TEK receptor tyrosine kinase. (1124 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | DRD2 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa) |
| | IL6 | Interleukin 6 (Interferon, beta 2). (234 aa) |
| | VSTM4 | V-set and transmembrane domain containing 4. (320 aa) |
| | SMO-2 | Smoothened, frizzled class receptor. (786 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa) |
| | LOXL2 | LOXL2 isoform 4. (744 aa) |
| | RUNX2 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa) |
| | XBP1 | XBP1 isoform 4. (381 aa) |
| | CTNNB1 | Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa) |
| | PPARD | Peroxisome proliferator-activated receptor delta. (441 aa) |
| | NRARP | NOTCH regulated ankyrin repeat protein. (114 aa) |
| | NOTCH1 | NOTCH1 isoform 1. (2555 aa) |
| | B4GALT1 | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 1. (398 aa) |
| | ENSPTRP00000064416 | annotation not available (502 aa) |
| | CALCA | Calcitonin related polypeptide alpha. (141 aa) |
| | CYP7B1 | Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (506 aa) |
| | EPHA2 | EPH receptor A2. (976 aa) |
| | KDF1 | Keratinocyte differentiation factor 1. (398 aa) |
| | COL8A2 | COL8A2 isoform 1. (921 aa) |
| | PROK1 | PROK1 isoform 1. (105 aa) |
| | STK4 | Serine/threonine-protein kinase 4. (487 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1127 aa) |
| | AREG | AREG isoform 2. (274 aa) |
