STRINGSTRING
IL26 IL26 RUNX3 RUNX3 KDF1 KDF1 ENSPTRP00000093022 ENSPTRP00000093022 IRF6 IRF6 PHB2 PHB2 STAT1 STAT1 PTEN PTEN MEF2C MEF2C CDKN1C CDKN1C CDC73 CDC73 ENSPTRP00000087640 ENSPTRP00000087640 PTCH1 PTCH1 VASH1 VASH1 DUSP10 DUSP10 WNT5A WNT5A LIMS2 LIMS2 VDR VDR AIMP1 AIMP1 MTSS1 MTSS1 CDKN2B CDKN2B MCC MCC KLF9 KLF9 NKX3-1 NKX3-1 STK3 STK3 BMP4-2 BMP4-2 TRIM24-2 TRIM24-2 PTPRK PTPRK NR2F2 NR2F2 SLURP1 SLURP1 GHRL GHRL MAGED1 MAGED1 CDKN2A CDKN2A AR AR PPARG PPARG ENSPTRP00000075918 ENSPTRP00000075918 FLCN FLCN CD109 CD109 ROBO1 ROBO1 RGN-2 RGN-2 SULF1 SULF1 TGFBR1 TGFBR1 EAF2 EAF2 DAB2 DAB2 IFT172 IFT172 DLL4 DLL4 TNF TNF DRD2 DRD2 GDF2 GDF2 CCL2 CCL2 ATOH8 ATOH8 ALOX5 ALOX5 DLG1 DLG1 THBS1 THBS1 TGFBR3 TGFBR3 PAX6 PAX6 RAP1GAP RAP1GAP ATP5F1A ATP5F1A GATA3 GATA3 KRIT1-2 KRIT1-2 ATF2 ATF2 STK4 STK4 ZEB1 ZEB1 CAV2 CAV2 NFIB NFIB SFN SFN DAB2IP DAB2IP APOE APOE MARVELD3 MARVELD3 SFRP1 SFRP1 CASK CASK WDR13 WDR13 SOX2 SOX2 TNMD TNMD PPARD PPARD PEX2 PEX2 RGN RGN NOTCH1 NOTCH1 ENG ENG B4GALT1 B4GALT1 IFT74 IFT74 TBC1D31 TBC1D31 RIDA RIDA SNAI2 SNAI2 TRIM24 TRIM24 CAV1 CAV1 CDK6 CDK6 KRIT1 KRIT1 PRL PRL IL12B IL12B SPARC SPARC ISL1 ISL1 SFRP2 SFRP2 FBXW7 FBXW7 INTU INTU EREG EREG PHOX2B PHOX2B PDCD10 PDCD10 IFT80 IFT80 IL12A IL12A A4GNT A4GNT IFT57 IFT57 IFT52 IFT52 GDF5 GDF5 COL4A3 COL4A3 SCG2 SCG2 XDH XDH CEACAM1 CEACAM1 TGFB1 TGFB1 HPN HPN STK11 STK11 PTPRM PTPRM SOX9 SOX9 APOH APOH NGFR NGFR MED1 MED1 NF1 NF1 ATP5IF1 ATP5IF1 WDR77 WDR77 TGFB2 TGFB2 MMRN2 MMRN2 FGFR2 FGFR2 MEN1 MEN1 OVOL1 OVOL1 AQP11 AQP11 CDKN1B CDKN1B WNT10B WNT10B ACVRL1 ACVRL1 SERPINF1 SERPINF1 NUPR1 NUPR1 NLRC3 NLRC3 B2M B2M SYNJ2BP SYNJ2BP BMP4 BMP4 SAV1 SAV1 NKX2-8 NKX2-8 TINF2 TINF2 EFNB2 EFNB2 CNMD CNMD RB1 RB1 CPB2 CPB2 RGCC RGCC BRCA2 BRCA2 FLT1 FLT1 PDX1 PDX1 KRT4 KRT4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL26IL26 isoform 1. (171 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
ENSPTRP00000093022annotation not available (563 aa)
IRF6Interferon regulatory factor 6. (467 aa)
PHB2Prohibitin. (299 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
CDKN1CCDKN1C isoform 1. (288 aa)
CDC73Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog. (531 aa)
ENSPTRP00000087640annotation not available (475 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
VASH1VASH1 isoform 1. (365 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (488 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (365 aa)
VDRVitamin D (1,25-dihydroxyvitamin D3) receptor. (477 aa)
AIMP1AIMP1 isoform 1. (321 aa)
MTSS1MTSS I-BAR domain containing 1. (759 aa)
CDKN2BCyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (138 aa)
MCCColorectal mutant cancer protein isoform X6. (1015 aa)
KLF9Kruppel-like factor 9. (244 aa)
NKX3-1NKX3-1 isoform 1. (234 aa)
STK3Serine/threonine kinase 3. (519 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
TRIM24-2Tripartite motif containing 24. (1050 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1472 aa)
NR2F2Nuclear receptor subfamily 2, group F, member 2. (414 aa)
SLURP1Secreted LY6/PLAUR domain containing 1. (103 aa)
GHRLGHRL isoform 10. (117 aa)
MAGED1MAGE family member D1. (834 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
ENSPTRP00000075918annotation not available (365 aa)
FLCNT0180863 isoform 1. (579 aa)
CD109CD109 isoform 3. (1446 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
RGN-2Regucalcin. (299 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (901 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
EAF2ELL associated factor 2. (263 aa)
DAB2Disabled homolog 2, mitogen-responsive phosphoprotein. (770 aa)
IFT172Intraflagellar transport 172 homolog. (1767 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
GDF2GDF2 isoform 1. (429 aa)
CCL2C-C motif chemokine. (109 aa)
ATOH8Atonal bHLH transcription factor 8. (323 aa)
ALOX5ALOX5 isoform 2. (785 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
THBS1Thrombospondin 1. (1173 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
PAX6PAX6 isoform 13. (436 aa)
RAP1GAPRAP1GAP isoform 8. (778 aa)
ATP5F1AATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (576 aa)
GATA3GATA binding protein 3. (444 aa)
KRIT1-2KRIT1 ankyrin repeat containing. (736 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
SFNSFN isoform 1; Belongs to the 14-3-3 family. (248 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
MARVELD3MARVEL domain containing 3. (410 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (921 aa)
WDR13WD repeat-containing protein 13. (542 aa)
SOX2SRY-box transcription factor 2. (319 aa)
TNMDTNMD isoform 1. (317 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
PEX2Peroxisomal membrane protein 3, 35kDa. (305 aa)
RGNRegucalcin (Senescence marker protein-30). (299 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ENGENG isoform 1. (658 aa)
B4GALT1UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 1. (398 aa)
IFT74Intraflagellar transport 74 homolog. (600 aa)
TBC1D31TBC1 domain family member 31. (1066 aa)
RIDAReactive intermediate imine deaminase A homolog. (137 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
TRIM24Tripartite motif containing 24. (1054 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
KRIT1KRIT1, ankyrin repeat containing. (736 aa)
PRLPRL isoform 1. (227 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
ISL1ISL LIM homeobox 1. (349 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
INTUInturned planar cell polarity effector homolog. (911 aa)
EREGEREG isoform 1. (169 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
PDCD10Programmed cell death 10. (212 aa)
IFT80Intraflagellar transport protein 80 homolog. (763 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (340 aa)
IFT57Intraflagellar transport 57 homolog. (429 aa)
IFT52Intraflagellar transport 52 homolog. (437 aa)
GDF5GDF5 isoform 1. (501 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
SCG2Secretogranin II. (610 aa)
XDHXDH isoform 1. (1333 aa)
CEACAM1CEACAM1 isoform 3. (518 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
HPNHPN isoform 1; Belongs to the peptidase S1 family. (417 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
PTPRMPTPRM isoform 4. (1465 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
APOHBeta-2-glycoprotein 1; Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. (345 aa)
NGFRNerve growth factor receptor. (427 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
NF1Neurofibromin 1. (2839 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (106 aa)
WDR77Methylosome protein 50. (342 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MMRN2MMRN2 isoform 1. (949 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
MEN1MEN1 isoform 14. (615 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
SERPINF1SERPINF1 isoform 1; Belongs to the serpin family. (418 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
NLRC3NLRC3 isoform 4. (1112 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (96 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
NKX2-8NKX2-8 isoform 1. (239 aa)
TINF2TERF1-interacting nuclear factor 2. (453 aa)
EFNB2EFNB2 isoform 1; Belongs to the ephrin family. (333 aa)
CNMDCNMD isoform 4. (334 aa)
RB1RB transcriptional corepressor 1. (928 aa)
CPB2Carboxypeptidase B2. (423 aa)
RGCCChromosome 13 open reading frame 15. (137 aa)
BRCA2Breast cancer 2, early onset. (3418 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
KRT4KRT4 isoform 1; Belongs to the intermediate filament family. (608 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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