STRINGSTRING
NR2E1 NR2E1 SKI SKI DRAXIN DRAXIN KDM4A KDM4A SEMA6C SEMA6C TRIM46 TRIM46 KIFAP3 KIFAP3 TNR TNR GPR37L1 GPR37L1 NRP1 NRP1 BMPR1A BMPR1A PITX3 PITX3 NKX6-2 NKX6-2 F2 F2 THY1 THY1 SORL1 SORL1 APPL2 APPL2 RNF10 RNF10 RNF6 RNF6 RB1 RB1 PSEN1 PSEN1 B2M B2M PRTG PRTG SEMA7A SEMA7A SEMA4B SEMA4B MT3 MT3 TP53 TP53 NTN1 NTN1 NF1 NF1 TMEM98 TMEM98 NR1D1 NR1D1 WNT3 WNT3 NOG NOG SYT4 SYT4 SEMA6B SEMA6B PTPRS PTPRS SIRT2 SIRT2 TGFB1 TGFB1 TLX2 TLX2 SEMA4C SEMA4C IL1B IL1B DLX2 DLX2 CTDSP1 CTDSP1 BMP7 BMP7 YWHAH YWHAH GORASP1 GORASP1 SEMA3G SEMA3G SEMA5B SEMA5B RYK RYK NKX6-1 NKX6-1 SEMA5A SEMA5A FSTL4 FSTL4 CDKL3 CDKL3 CTNNA1 CTNNA1 KIAA0319 KIAA0319 TREM2 TREM2 EPHA7 EPHA7 DYNLT1 DYNLT1 SEMA3C SEMA3C SEMA3A SEMA3A SEMA3D SEMA3D PCM1 PCM1 HOOK3 HOOK3 BRINP1 BRINP1 LHX2 LHX2 NOTCH1 NOTCH1 TRPC5 TRPC5 PLXNA3 PLXNA3 DLX1 DLX1 REST REST MAP2 MAP2 CERS2 CERS2 HES5 HES5 SPART SPART TSPO TSPO SOX10 SOX10 BCL11A BCL11A SEMA4F SEMA4F IFRD1 IFRD1 CTNNB1 CTNNB1 DICER1 DICER1 GDI1 GDI1 ABCC8 ABCC8 CD22-2 CD22-2 SEMA4D SEMA4D WNT3A WNT3A PROX1 PROX1 LINGO1 LINGO1 DPYSL5 DPYSL5 DAB1 DAB1 EPHB2 EPHB2 ATOH1 ATOH1 RTN4 RTN4 IFRD2 IFRD2 ID1 ID1 SYNGAP1 SYNGAP1 MCF2 MCF2 DLL3 DLL3 HES1 HES1 ENSPTRP00000064416 ENSPTRP00000064416 WNT7A WNT7A PAX6 PAX6 SEMA3E SEMA3E SEMA6A SEMA6A FGF13 FGF13 PPP3CA PPP3CA IL6 IL6 DCC DCC SEMA4A SEMA4A ENSPTRP00000068785 ENSPTRP00000068785 MBD1 MBD1 ENSPTRP00000069560 ENSPTRP00000069560 TRIM11 TRIM11 ID4 ID4 NF2 NF2 DAAM2 DAAM2 DIP2B DIP2B LDLR LDLR ENSPTRP00000075867 ENSPTRP00000075867 SEMA4G SEMA4G ENSPTRP00000077268 ENSPTRP00000077268 WNT3-2 WNT3-2 ENSPTRP00000078533 ENSPTRP00000078533 RAPGEF2 RAPGEF2 SEMA3F SEMA3F CDK5 CDK5 IL6-2 IL6-2 ENSPTRP00000080343 ENSPTRP00000080343 PTN PTN HES5-2 HES5-2 ENSPTRP00000080680 ENSPTRP00000080680 ASCL2 ASCL2 SEMA6D SEMA6D LRP4 LRP4 ENSPTRP00000082268 ENSPTRP00000082268 CDKN2B CDKN2B SLIT1 SLIT1 ENSPTRP00000085189 ENSPTRP00000085189 ID1-2 ID1-2 ENSPTRP00000085820 ENSPTRP00000085820 WNT5A WNT5A DUSP10 DUSP10 SEMA3B SEMA3B ENSPTRP00000087014 ENSPTRP00000087014 RTN4R RTN4R EFNB3 EFNB3 ARHGAP4 ARHGAP4 LIN28A LIN28A VAX1 VAX1 NFATC4 NFATC4 ENSPTRP00000089676 ENSPTRP00000089676 PTEN PTEN SOX11 SOX11 NR2E1-2 NR2E1-2 RUFY3 RUFY3 SPP1 SPP1 ULK2 ULK2 ENSPTRP00000093022 ENSPTRP00000093022 CCL11 CCL11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
KDM4ALysine (K)-specific demethylase 4A. (1064 aa)
SEMA6CSEMA6C isoform 2; Belongs to the semaphorin family. (962 aa)
TRIM46Tripartite motif containing 46. (759 aa)
KIFAP3Kinesin-associated protein 3. (792 aa)
TNRTNR isoform 1. (1358 aa)
GPR37L1G protein-coupled receptor 37 like 1. (481 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PITX3Homeobox protein. (302 aa)
NKX6-2NKX6-2 isoform 1. (276 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
THY1Thy-1 cell surface antigen. (161 aa)
SORL1Sortilin related receptor 1. (2214 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa)
RNF10Ring finger protein 10. (816 aa)
RNF6Ring finger protein (C3H2C3 type) 6. (685 aa)
RB1RB transcriptional corepressor 1. (928 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (96 aa)
PRTGPRTG isoform 2. (1150 aa)
SEMA7ASEMA7A isoform 1; Belongs to the semaphorin family. (664 aa)
SEMA4BSEMA4B isoform 1; Belongs to the semaphorin family. (836 aa)
MT3MT3 isoform 5; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
NTN1NTN1 isoform 1. (604 aa)
NF1Neurofibromin 1. (2839 aa)
TMEM98Transmembrane protein 98. (226 aa)
NR1D1Nuclear receptor subfamily 1, group D, member 1. (614 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SYT4Synaptotagmin 4. (425 aa)
SEMA6BSema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6B; Belongs to the semaphorin family. (888 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TLX2T-cell leukemia homeobox 2. (284 aa)
SEMA4CSEMA4C isoform 2; Belongs to the semaphorin family. (833 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
DLX2Distal-less homeobox 2. (328 aa)
CTDSP1CTD small phosphatase 1. (261 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family. (246 aa)
GORASP1Golgi reassembly stacking protein 1, 65kDa. (440 aa)
SEMA3GSEMA3G isoform 2; Belongs to the semaphorin family. (782 aa)
SEMA5BSEMA5B isoform 1. (1352 aa)
RYKReceptor like tyrosine kinase. (610 aa)
NKX6-1NKX6-1 isoform 2. (367 aa)
SEMA5ASEMA5A isoform 1. (1074 aa)
FSTL4Follistatin like 4. (842 aa)
CDKL3Cyclin dependent kinase like 3. (592 aa)
CTNNA1CTNNA1 isoform 21. (906 aa)
KIAA0319KIAA0319 isoform 5. (1072 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
EPHA7EPHA7 isoform 2. (998 aa)
DYNLT1Dynein, light chain, Tctex-type 1. (113 aa)
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
SEMA3ASEMA3A isoform 1; Belongs to the semaphorin family. (771 aa)
SEMA3DSEMA3D isoform 1; Belongs to the semaphorin family. (777 aa)
PCM1Pericentriolar material 1. (2024 aa)
HOOK3Protein Hook homolog 3 isoform X2. (718 aa)
BRINP1BMP/retinoic acid inducible neural specific 1. (761 aa)
LHX2LHX2 isoform 1. (406 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (973 aa)
PLXNA3PLXNA3 isoform 1. (1871 aa)
DLX1Distal-less homeobox 1. (255 aa)
RESTRE1 silencing transcription factor. (1097 aa)
MAP2Microtubule-associated protein. (1827 aa)
CERS2LAG1 homolog, ceramide synthase 2. (380 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
SPARTSpastic paraplegia 20 (Troyer syndrome). (665 aa)
TSPOTranslocator protein. (169 aa)
SOX10SRY-box transcription factor 10. (466 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (835 aa)
SEMA4FSEMA4F isoform 1; Belongs to the semaphorin family. (770 aa)
IFRD1Interferon-related developmental regulator 1. (452 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
DICER1Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
GDI1Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes (By similarity). (456 aa)
ABCC8ABCC8 isoform 2. (1582 aa)
CD22-2B-cell receptor CD22. (626 aa)
SEMA4DSEMA4D isoform 13; Belongs to the semaphorin family. (862 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PROX1Prospero homeobox 1. (737 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
DPYSL5DPYSL5 isoform 1. (565 aa)
DAB1DAB adaptor protein 1. (588 aa)
EPHB2EPH receptor B2. (1055 aa)
ATOH1Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). (356 aa)
RTN4Reticulon. (1192 aa)
IFRD2Interferon-related developmental regulator 2. (510 aa)
ID1Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein. (155 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1345 aa)
MCF2MCF2 isoform 7. (1044 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ENSPTRP00000064416annotation not available (502 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
PAX6PAX6 isoform 13. (436 aa)
SEMA3ESEMA3E isoform 1; Belongs to the semaphorin family. (775 aa)
SEMA6ASEMA6A isoform 2; Belongs to the semaphorin family. (1047 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
DCCDCC isoform 1. (1457 aa)
SEMA4ASEMA4A isoform 10; Belongs to the semaphorin family. (761 aa)
ENSPTRP00000068785annotation not available (127 aa)
MBD1Methyl-CpG binding domain protein 1. (630 aa)
ENSPTRP00000069560annotation not available (214 aa)
TRIM11Tripartite motif containing 11. (468 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1077 aa)
DIP2BDIP2 disco-interacting protein 2 homolog B. (1578 aa)
LDLRLDLR isoform 7. (917 aa)
ENSPTRP00000075867annotation not available (618 aa)
SEMA4GSEMA4G isoform 3; Belongs to the semaphorin family. (843 aa)
ENSPTRP00000077268annotation not available (202 aa)
WNT3-2Wnt family member 3. (290 aa)
ENSPTRP00000078533annotation not available (144 aa)
RAPGEF2RAPGEF2 isoform 2. (1701 aa)
SEMA3FSEMA3F isoform 2; Belongs to the semaphorin family. (785 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
IL6-2Interleukin 6. (234 aa)
ENSPTRP00000080343annotation not available (123 aa)
PTNPTN isoform 2. (172 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
ENSPTRP00000080680annotation not available (560 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
SEMA6DSema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6D; Belongs to the semaphorin family. (1086 aa)
LRP4Low density lipoprotein receptor-related protein 4. (1906 aa)
ENSPTRP00000082268annotation not available (246 aa)
CDKN2BCyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (138 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
ENSPTRP00000085189annotation not available (1896 aa)
ID1-2Inhibitor of DNA binding 1, HLH protein. (155 aa)
ENSPTRP00000085820annotation not available (199 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (488 aa)
SEMA3BSEMA3B isoform 2; Belongs to the semaphorin family. (749 aa)
ENSPTRP00000087014annotation not available (777 aa)
RTN4RRTN4R isoform 1. (472 aa)
EFNB3EFNB3 isoform 1; Belongs to the ephrin family. (340 aa)
ARHGAP4Rho GTPase activating protein 4. (986 aa)
LIN28ALIN28A isoform 1. (209 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
ENSPTRP00000089676annotation not available (850 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SOX11Transcription factor SOX. (441 aa)
NR2E1-2Nuclear receptor subfamily 2 group E member 1. (385 aa)
RUFY3RUN and FYVE domain containing 3. (638 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
ULK2Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1036 aa)
ENSPTRP00000093022annotation not available (563 aa)
CCL11C-C motif chemokine. (97 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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