STRINGSTRING
TRPC5 TRPC5 PLXNA3 PLXNA3 FN1 FN1 BCL11A BCL11A STK25 STK25 BMPR2 BMPR2 SEMA4D SEMA4D WNT3A WNT3A SHTN1 SHTN1 LIMK1 LIMK1 RUFY3 RUFY3 PLXNB3 PLXNB3 SHOX2 SHOX2 ROBO2 ROBO2 ENSPTRP00000090382 ENSPTRP00000090382 BRAF-2 BRAF-2 PLXNA1 PLXNA1 LOC100615317 LOC100615317 OCM-2 OCM-2 DBN1 DBN1 ENSPTRP00000086254 ENSPTRP00000086254 ENSPTRP00000084830 ENSPTRP00000084830 NIN NIN TIAM2 TIAM2 ENSPTRP00000080680 ENSPTRP00000080680 L1CAM L1CAM LAYN LAYN SLIT2 SLIT2 BRAF BRAF LIMK1-2 LIMK1-2 DISC1 DISC1 DBNL-2 DBNL-2 WNT3-2 WNT3-2 NTRK2 NTRK2 PLXNB2 PLXNB2 NEFL NEFL PLXNC1 PLXNC1 ROBO1 ROBO1 CHODL CHODL NDEL1-2 NDEL1-2 OCM2-2 OCM2-2 NGF NGF SKIL SKIL RND2 RND2 CXCL12 CXCL12 METRN METRN IST1 IST1 MACF1 MACF1 PLXNA4 PLXNA4 BDNF BDNF WNT3 WNT3 MAPT MAPT TRPV2 TRPV2 NTN1 NTN1 NDEL1 NDEL1 SEMA7A SEMA7A CYFIP1 CYFIP1 SLITRK1 SLITRK1 MAP6 MAP6 ZFYVE27 ZFYVE27 NRP1 NRP1 PLXNA2 PLXNA2 CRABP2 CRABP2 AMIGO1 AMIGO1 LPAR3 LPAR3 STK11 STK11 MAP2K2 MAP2K2 MEGF8 MEGF8 ADNP ADNP CDH4 CDH4 TIAM1 TIAM1 DSCAM DSCAM PLXNB1 PLXNB1 GOLGA4 GOLGA4 AMIGO3 AMIGO3 TWF2 TWF2 PLXND1 PLXND1 MAP3K13 MAP3K13 POU4F2 POU4F2 SEMA5A SEMA5A MAP1B MAP1B EFNA5 EFNA5 SRF SRF DIXDC1 DIXDC1 OCM OCM DBNL DBNL OCM2 OCM2 ANAPC2 ANAPC2 CDKL5 CDKL5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (973 aa)
PLXNA3PLXNA3 isoform 1. (1871 aa)
FN1FN1 isoform 1. (2477 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (835 aa)
STK25Serine/threonine kinase 25. (426 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
SEMA4DSEMA4D isoform 13; Belongs to the semaphorin family. (862 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SHTN1SHTN1 isoform 3. (636 aa)
LIMK1LIM domain kinase 1. (677 aa)
RUFY3RUN and FYVE domain containing 3. (638 aa)
PLXNB3PLXNB3 isoform 1. (1932 aa)
SHOX2SHOX2 isoform 2. (343 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
ENSPTRP00000090382annotation not available (493 aa)
BRAF-2BRAF isoform 2. (766 aa)
PLXNA1PLXNA1 isoform 1. (1915 aa)
LOC100615317IST1 isoform 5. (331 aa)
OCM-2Oncomodulin. (136 aa)
DBN1DBN1 isoform 1. (695 aa)
ENSPTRP00000086254Microtubule-associated protein tau. (776 aa)
ENSPTRP00000084830annotation not available (340 aa)
NINNIN isoform 1. (2133 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1730 aa)
ENSPTRP00000080680annotation not available (560 aa)
L1CAML1 cell adhesion molecule. (1257 aa)
LAYNLAYN isoform 4. (382 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
LIMK1-2LIM domain kinase 1. (677 aa)
DISC1Disrupted in schizophrenia 1 protein isoform X1. (977 aa)
DBNL-2Drebrin like. (439 aa)
WNT3-2Wnt family member 3. (290 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
PLXNB2PLXNB2 isoform 1. (1838 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (543 aa)
PLXNC1PLXNC1 isoform 1. (1568 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
CHODLCHODL isoform 3. (277 aa)
NDEL1-2NudE nuclear distribution gene E homolog-like 1. (351 aa)
OCM2-2Putative oncomodulin-2 isoform X1. (136 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
SKILSKI like proto-oncogene. (684 aa)
RND2Rho family GTPase 2. (227 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
METRNMeteorin, glial cell differentiation regulator. (293 aa)
IST1IST1 factor associated with ESCRT-III. (376 aa)
MACF1Microtubule actin crosslinking factor 1. (7594 aa)
PLXNA4PLXNA4 isoform 1. (1894 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
MAPTMicrotubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabili [...] (776 aa)
TRPV2Transient receptor potential cation channel, subfamily V, member 2; Belongs to the transient receptor (TC 1.A.4) family. (764 aa)
NTN1NTN1 isoform 1. (604 aa)
NDEL1NudE nuclear distribution gene E homolog-like 1. (345 aa)
SEMA7ASEMA7A isoform 1; Belongs to the semaphorin family. (664 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
SLITRK1SLITRK1 isoform 1. (580 aa)
MAP6Microtubule associated protein 6. (815 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (416 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PLXNA2PLXNA2 isoform 1. (1909 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
AMIGO1Adhesion molecule with Ig-like domain 1. (493 aa)
LPAR3Lysophosphatidic acid receptor 3. (353 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
ADNPActivity-dependent neuroprotector homeobox. (1102 aa)
CDH4CDH4 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (916 aa)
TIAM1T-cell lymphoma invasion and metastasis 1. (1591 aa)
DSCAMDS cell adhesion molecule. (2012 aa)
PLXNB1PLXNB1 isoform 1. (2135 aa)
GOLGA4GOLGA4 isoform 4. (2243 aa)
AMIGO3AMIGO3 isoform 1. (504 aa)
TWF2T0016682 isoform 2. (349 aa)
PLXND1PLXND1 isoform 1. (1925 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
POU4F2POU domain protein. (406 aa)
SEMA5ASEMA5A isoform 1. (1074 aa)
MAP1BMicrotubule associated protein 1B. (2468 aa)
EFNA5EFNA5 isoform 1; Belongs to the ephrin family. (228 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
DIXDC1DIX domain containing 1. (683 aa)
OCMOCM isoform 1; Belongs to the parvalbumin family. (109 aa)
DBNLDBNL isoform 5. (439 aa)
OCM2OCM2 isoform 1; Belongs to the parvalbumin family. (109 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
CDKL5Cyclin dependent kinase like 5. (1030 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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