STRINGSTRING
BAD BAD CELA2A CELA2A NR0B2 NR0B2 SLC16A1 SLC16A1 ENSA ENSA MPC2 MPC2 GLUL GLUL PFKFB2 PFKFB2 RBP4 RBP4 SYT9 SYT9 OSBP OSBP TCIRG1 TCIRG1 UCP2 UCP2 SIDT2 SIDT2 KCNA5 KCNA5 TM7SF3 TM7SF3 IFNG IFNG SLC8B1 SLC8B1 SIRT4 SIRT4 PSMD9 PSMD9 AACS AACS PDX1 PDX1 FOXO1 FOXO1 IRS2 IRS2 PCK2 PCK2 HIF1A HIF1A CHGA CHGA BAIAP3 BAIAP3 ABAT ABAT RPH3AL RPH3AL NOS2 NOS2 NR1D1 NR1D1 GIP GIP SIRT6 SIRT6 FFAR1 FFAR1 TRPM4 TRPM4 VSNL1 VSNL1 FKBP1B FKBP1B PRKCE PRKCE IL1B IL1B ACVR1C ACVR1C G6PC2 G6PC2 ABCA12 ABCA12 IRS1 IRS1 CAPN10 CAPN10 NNAT NNAT KCNB1 KCNB1 LRP5L LRP5L PICK1 PICK1 PLA2G6 PLA2G6 JAGN1 JAGN1 MYRIP MYRIP STXBP5L STXBP5L ADCY5 ADCY5 TRH TRH CDV3 CDV3 SERP1 SERP1 GHSR GHSR CD38 CD38 CLOCK CLOCK EPHA5 EPHA5 NKX6-1 NKX6-1 ISL1 ISL1 EFNA5 EFNA5 GPLD1 GPLD1 RFX6 RFX6 PRKN PRKN ICA1 ICA1 STX1A STX1A CFTR CFTR SLC30A8 SLC30A8 CCN3 CCN3 LRRC8A LRRC8A CDK16 CDK16 SYTL4 SYTL4 ACSL4 ACSL4 REST REST PFKL PFKL FAM3D FAM3D CASR CASR GCK GCK PPARD PPARD MTNR1B MTNR1B ABCC8 ABCC8 KCNJ11 KCNJ11 CARTPT CARTPT BLK BLK GCG GCG SOX4 SOX4 UCN3 UCN3 STXBP4 STXBP4 NLGN2 NLGN2 SFRP1 SFRP1 DOC2B DOC2B PFKM PFKM PTPN11 PTPN11 ADRA2A ADRA2A KLF7 KLF7 BIRC5 BIRC5 GIPR GIPR CK820_G0042363 CK820_G0042363 HADH HADH MIDN MIDN C2CD2L C2CD2L PPP3CB PPP3CB SLC25A22 SLC25A22 LOC739722 LOC739722 ARNTL ARNTL ALOX5 ALOX5 ENSPTRP00000067174 ENSPTRP00000067174 PPP3CA PPP3CA TRPM2 TRPM2 IL6 IL6 LRP5 LRP5 TNF TNF PER2 PER2 PIM3 PIM3 CPT1A CPT1A SYT7 SYT7 NR1H4 NR1H4 SSTR5 SSTR5 LEP LEP PTPN11-2 PTPN11-2 C1QTNF12 C1QTNF12 ENSPTRP00000074763 ENSPTRP00000074763 SLC9B2 SLC9B2 SREBF1 SREBF1 MCU MCU ENSPTRP00000077211 ENSPTRP00000077211 ADCY8 ADCY8 TFAP2B TFAP2B ENSPTRP00000077599 ENSPTRP00000077599 ANO1 ANO1 GHRL GHRL STX4 STX4 ENSPTRP00000080134 ENSPTRP00000080134 IL6-2 IL6-2 SRI SRI TCF7L2 TCF7L2 SRI-2 SRI-2 JAK2 JAK2 NDUFAF2 NDUFAF2 EIPR1 EIPR1 CCL5 CCL5 OXCT1 OXCT1 HNF1A HNF1A ENSPTRP00000085680 ENSPTRP00000085680 HMGN3 HMGN3 GPR68 GPR68 ENSPTRP00000086541 ENSPTRP00000086541 CK820_G0014959 CK820_G0014959 RFX3 RFX3 TUNAR TUNAR HNF4A HNF4A STX1A-2 STX1A-2 LOC473221 LOC473221 ENSPTRP00000089297 ENSPTRP00000089297 CK820_G0030015 CK820_G0030015 FOXA2 FOXA2 GPR27 GPR27 INHBB INHBB BRSK2 BRSK2 ENSPTRP00000092364 ENSPTRP00000092364 CK820_G0029100 CK820_G0029100
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BADBcl2-associated agonist of cell death. (168 aa)
CELA2ACELA2A isoform 1; Belongs to the peptidase S1 family. (278 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
SLC16A1Solute carrier family 16, member 1 (Monocarboxylic acid transporter 1). (500 aa)
ENSAEndosulfine alpha. (187 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
GLULGlutamine synthetase. (373 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2. (522 aa)
RBP4Retinol-binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. (201 aa)
SYT9Synaptotagmin IX. (491 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (807 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
SIDT2SID1 transmembrane family member 2 isoform X7. (854 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (602 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
SLC8B1Solute carrier family 24 (Sodium/potassium/calcium exchanger), member 6; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (584 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
PSMD9Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 9. (223 aa)
AACSAcetoacetyl-CoA synthetase. (672 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
FOXO1FOXO1 isoform 1. (655 aa)
IRS2IRS2 isoform 1. (1340 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
CHGACHGA isoform 1. (459 aa)
BAIAP3BAIAP3 isoform 4. (1172 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (515 aa)
RPH3ALUncharacterized protein. (301 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa)
NR1D1Nuclear receptor subfamily 1, group D, member 1. (614 aa)
GIPGastric inhibitory polypeptide. (153 aa)
SIRT6SIRT6 isoform 1. (355 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
VSNL1VSNL1 isoform 1. (191 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
CAPN10CAPN10 isoform 1; Belongs to the peptidase C2 family. (672 aa)
NNATNNAT isoform 1. (81 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
LRP5LLDL receptor related protein 5 like. (252 aa)
PICK1Protein interacting with PRKCA 1. (416 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
JAGN1Jagunal homolog 1. (183 aa)
MYRIPMYRIP isoform 1. (805 aa)
STXBP5LSyntaxin binding protein 5 like. (1186 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (240 aa)
CDV3CDV3 isoform 2. (211 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CD38CD38 isoform 1. (300 aa)
CLOCKClock circadian regulator. (847 aa)
EPHA5EPH receptor A5. (1038 aa)
NKX6-1NKX6-1 isoform 2. (367 aa)
ISL1ISL LIM homeobox 1. (349 aa)
EFNA5EFNA5 isoform 1; Belongs to the ephrin family. (228 aa)
GPLD1GPLD1 isoform 2. (840 aa)
RFX6RFX6 isoform 1. (928 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
ICA1Islet cell autoantigen 1. (512 aa)
STX1ASTX1A isoform 3; Belongs to the syntaxin family. (288 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
CCN3NOV isoform 1. (357 aa)
LRRC8ALeucine rich repeat containing 8 family, member A. (810 aa)
CDK16Cyclin dependent kinase 16. (570 aa)
SYTL4Synaptotagmin-like 4. (672 aa)
ACSL4Acyl-CoA synthetase long-chain family member 4. (749 aa)
RESTRE1 silencing transcription factor. (1097 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
FAM3DFamily with sequence similarity 3 member D. (224 aa)
CASRCalcium sensing receptor. (1078 aa)
GCKPhosphotransferase. (466 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (362 aa)
ABCC8ABCC8 isoform 2. (1582 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
CARTPTCART prepropeptide. (116 aa)
BLKTyrosine-protein kinase. (505 aa)
GCGGCG isoform 1. (180 aa)
SOX4Transcription factor SOX. (474 aa)
UCN3UCN3 isoform 1. (161 aa)
STXBP4Syntaxin binding protein 4. (553 aa)
NLGN2NLGN2 isoform 1. (836 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ADRA2AAdrenergic, alpha-2A-, receptor. (465 aa)
KLF7Kruppel-like factor 7 (Ubiquitous). (302 aa)
BIRC5Baculoviral IAP repeat containing 5. (165 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
HADHHydroxyacyl-CoA dehydrogenase. (390 aa)
MIDNMIDN isoform 1. (468 aa)
C2CD2LC2CD2L isoform 1. (711 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
SLC25A22Solute carrier family 25 (Mitochondrial carrier: glutamate), member 22; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
LOC739722NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 pseudogene. (156 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like. (628 aa)
ALOX5ALOX5 isoform 2. (785 aa)
ENSPTRP00000067174annotation not available (502 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
TRPM2TRPM2 isoform 4. (1393 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
PER2Period circadian regulator 2. (1255 aa)
PIM3Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (310 aa)
CPT1ACarnitine palmitoyltransferase 1A (Liver); Belongs to the carnitine/choline acetyltransferase family. (773 aa)
SYT7Synaptotagmin 7. (686 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
SSTR5SSTR5 isoform 1; Belongs to the G-protein coupled receptor 1 family. (320 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
C1QTNF12C1q and TNF related 12. (302 aa)
ENSPTRP00000074763annotation not available (520 aa)
SLC9B2Solute carrier family 9B (sodium/hydrogen exchanger), member 1/2. (537 aa)
SREBF1SREBF1 isoform 6. (1177 aa)
MCUCoiled-coil domain containing 109A. (352 aa)
ENSPTRP00000077211annotation not available (269 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
ENSPTRP00000077599Acetoacetyl-CoA synthetase-like. (220 aa)
ANO1Anoctamin. (986 aa)
GHRLGHRL isoform 10. (117 aa)
STX4STX4 isoform 4; Belongs to the syntaxin family. (297 aa)
ENSPTRP00000080134annotation not available (124 aa)
IL6-2Interleukin 6. (234 aa)
SRISRI isoform 1. (205 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
SRI-2SRI isoform 5. (237 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
NDUFAF2NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex, assembly factor 2. (169 aa)
EIPR1EARP complex and GARP complex interacting protein 1. (414 aa)
CCL5C-C motif chemokine. (91 aa)
OXCT1Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (557 aa)
HNF1AHNF1 homeobox A. (662 aa)
ENSPTRP00000085680annotation not available (88 aa)
HMGN3High mobility group nucleosomal binding domain 3. (130 aa)
GPR68GPR68 isoform 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
ENSPTRP00000086541annotation not available (90 aa)
CK820_G0014959KLF7 isoform 7. (258 aa)
RFX3RFX3 isoform 4. (761 aa)
TUNARTCL1 upstream neural differentiation-associated RNA. (48 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
STX1A-2Syntaxin 1A. (344 aa)
LOC473221Glutamine synthetase pseudogene. (351 aa)
ENSPTRP00000089297annotation not available (265 aa)
CK820_G0030015CDV3 isoform 4. (167 aa)
FOXA2FOXA2 isoform 1. (464 aa)
GPR27G protein-coupled receptor 27. (375 aa)
INHBBInhibin subunit beta B. (407 aa)
BRSK2BRSK2 isoform 5. (714 aa)
ENSPTRP00000092364annotation not available (574 aa)
CK820_G0029100SRI isoform 2. (98 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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