STRINGSTRING
ITGA2 ITGA2 KDR KDR CXCL8 CXCL8 VEGFC VEGFC S1PR1 S1PR1 PGF PGF AGER AGER CREB3 CREB3 AZU1 AZU1 F2RL1 F2RL1 SCG2 SCG2 SMAD3 SMAD3 NTF3 NTF3 NTRK3 NTRK3 ARTN ARTN CDH13 CDH13 IL16 IL16 VEGFD VEGFD F3 F3 CASR CASR VEGFB VEGFB CXCL12 CXCL12 FGF10 FGF10 CCR4 CCR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
AGERAdvanced glycosylation end-product specific receptor. (420 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
AZU1AZU1 isoform 1. (253 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
SCG2Secretogranin II. (610 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
NTRK3NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. (864 aa)
ARTNARTN isoform 11. (235 aa)
CDH13CDH13 isoform 2. (760 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4 (By similarity). (1332 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
CASRCalcium sensing receptor. (1078 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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