59 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SCN1A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
	HPN	HPN isoform 1; Belongs to the peptidase S1 family. (417 aa)
	CK820_G0054628	PKD1 isoform 4. (3384 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
	LOC742658	Stereocilin-like. (1726 aa)
	LHFPL5	LHFPL tetraspan subfamily member 5. (219 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	PIEZO2	Piezo-type mechanosensitive ion channel component. (2777 aa)
	ENSPTRP00000085692	annotation not available (679 aa)
	TMEM120A-2	Transmembrane protein 120A. (354 aa)
	PDZD7	PDZD7 isoform 1. (1035 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
	COL11A1	Collagen type XI alpha 1 chain. (1818 aa)
	PKD1L1-2	Polycystin 1 like 1, transient receptor potential channel interacting. (2857 aa)
	PTPRQ	PTPRQ isoform 2. (2158 aa)
	CDH2	Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
	ASIC3	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (549 aa)
	ITGA2	Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
	NTRK1	Tyrosine-protein kinase receptor. (796 aa)
	WHRN	WHRN isoform 2. (907 aa)
	TMEM120A	Transmembrane protein 120A. (354 aa)
	PCDH15	Protocadherin related 15. (1954 aa)
	ANO3	Anoctamin. (1042 aa)
	PKD2L1	Polycystin 2 like 1, transient receptor potential cation channel. (805 aa)
	CHRNA10	Cholinergic receptor nicotinic alpha 10 subunit. (450 aa)
	CSRP3	Cysteine and glycine rich protein 3. (194 aa)
	TMC1	Transmembrane channel-like protein. (760 aa)
	ADGRV1	ADGRV1 isoform 1; Belongs to the G-protein coupled receptor 2 family. (6306 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (968 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
	CHRNA9	Cholinergic receptor nicotinic alpha 9 subunit. (479 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	PKDREJ	Polycystin family receptor for egg jelly. (2251 aa)
	PKD1L1	PKD1L1 isoform 1. (2857 aa)
	CK820_G0056924	NPIPA2 isoform 1. (277 aa)
	PKD1L3	Polycystin 1 like 3, transient receptor potential channel interacting. (1732 aa)
	KCNA1	Potassium voltage-gated channel, shaker-related subfamily, member 1 (Episodic ataxia with myokymia); Belongs to the potassium channel family. (495 aa)
	MKKS	McKusick-Kaufman syndrome. (570 aa)
	KCNK4	Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (393 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	PAWR	PRKC, apoptosis, WT1, regulator. (340 aa)
	LRRIQ1	LRRIQ1 isoform 3. (1722 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (471 aa)
	STRC	LOW QUALITY PROTEIN: stereocilin. (1772 aa)
	PIEZO1	Piezo-type mechanosensitive ion channel component. (2516 aa)
	ASIC2	Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (563 aa)
	TCAP	TCAP isoform 1. (167 aa)
	JUP	Junction plakoglobin. (745 aa)
	PJVK	DFNB59 isoform 1. (352 aa)
	BACE1	Beta-site APP-cleaving enzyme 1; Belongs to the peptidase A1 family. (501 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (409 aa)
	PKD2L2	Polycystin 2 like 2, transient receptor potential cation channel. (624 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	TMC2	Transmembrane channel-like protein. (903 aa)
	PHF24	PHD finger protein 24. (400 aa)
	REST	RE1 silencing transcription factor. (1097 aa)
	TTN	TTN isoform 3. (32000 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRV1	LHFPL5	ENSPTRP00000029219	ENSPTRP00000066441	ADGRV1 isoform 1; Belongs to the G-protein coupled receptor 2 family.	LHFPL tetraspan subfamily member 5.	0.493
ADGRV1	PCDH15	ENSPTRP00000029219	ENSPTRP00000078994	ADGRV1 isoform 1; Belongs to the G-protein coupled receptor 2 family.	Protocadherin related 15.	0.785
ADGRV1	PDZD7	ENSPTRP00000029219	ENSPTRP00000087414	ADGRV1 isoform 1; Belongs to the G-protein coupled receptor 2 family.	PDZD7 isoform 1.	0.815
ADGRV1	SCN1A	ENSPTRP00000029219	ENSPTRP00000021517	ADGRV1 isoform 1; Belongs to the G-protein coupled receptor 2 family.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.475
ADGRV1	TMC1	ENSPTRP00000029219	ENSPTRP00000035938	ADGRV1 isoform 1; Belongs to the G-protein coupled receptor 2 family.	Transmembrane channel-like protein.	0.649
ADGRV1	WHRN	ENSPTRP00000029219	ENSPTRP00000068184	ADGRV1 isoform 1; Belongs to the G-protein coupled receptor 2 family.	WHRN isoform 2.	0.946
ASIC2	ASIC3	ENSPTRP00000015351	ENSPTRP00000081988	Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.430
ASIC3	ASIC2	ENSPTRP00000081988	ENSPTRP00000015351	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.430
ASIC3	PIEZO2	ENSPTRP00000081988	ENSPTRP00000076161	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Piezo-type mechanosensitive ion channel component.	0.466
ASIC3	TRPA1	ENSPTRP00000081988	ENSPTRP00000046657	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.544
BACE1	FYN	ENSPTRP00000007415	ENSPTRP00000077482	Beta-site APP-cleaving enzyme 1; Belongs to the peptidase A1 family.	Tyrosine-protein kinase.	0.449
BACE1	NTRK1	ENSPTRP00000007415	ENSPTRP00000083380	Beta-site APP-cleaving enzyme 1; Belongs to the peptidase A1 family.	Tyrosine-protein kinase receptor.	0.478
BACE1	SCN1A	ENSPTRP00000007415	ENSPTRP00000021517	Beta-site APP-cleaving enzyme 1; Belongs to the peptidase A1 family.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.483
CAV3	CSRP3	ENSPTRP00000025136	ENSPTRP00000005977	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Cysteine and glycine rich protein 3.	0.537
CAV3	CTNNB1	ENSPTRP00000025136	ENSPTRP00000044466	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.449
CAV3	FYN	ENSPTRP00000025136	ENSPTRP00000077482	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.932
CAV3	JUP	ENSPTRP00000025136	ENSPTRP00000015634	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin.	0.447
CAV3	KCNQ1	ENSPTRP00000025136	ENSPTRP00000087726	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.	0.532
CAV3	TCAP	ENSPTRP00000025136	ENSPTRP00000015502	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	TCAP isoform 1.	0.532
CAV3	TTN	ENSPTRP00000025136	ENSPTRP00000021693	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	TTN isoform 3.	0.556